piperovatine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

piperovatine: isolated from Ottonia frutescens; RN given refers to (E,E)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	5374352
CHEMBL ID	250442
SCHEMBL ID	10594251
MeSH ID	M0115464

Synonyms (16)

Synonym
piperovatine
CHEMBL250442
(2e,4e)-6-(4-methoxyphenyl)-n-(2-methylpropyl)hexa-2,4-dienamide
1400-93-7
(2e,4e)-6-(4-methoxyphenyl)-n-(2-methyl-propyl)-hexa-2,4-dienoic acid amide
n-isobutyl-6-(4-methoxyphenyl)sorbamide
2,4-hexadienamide, 6-(4-methoxyphenyl)-n-(2-methylpropyl)-, (e,e)-
25090-18-0
SCHEMBL10594251
sorbamide, n-isobutyl-6-(p-methoxyphenyl)-, (e,e)-
IHRWUVSXOBLEJV-DVBIZMGNSA-N
(2e,4e)-n-isobutyl-6-(4-methoxyphenyl)-2,4-hexadienamide #
piperovatine [(2e,4e)-n-isobutyl-6-(4-methoxyphenyl)hexa-2,4-dienamide]
2,4-hexadienamide,6-(4-methoxyphenyl)-n-(2-methylpropyl)-,(2e,4e)-
isobutylamide piperovatine
(2e,4e)-n-isobutyl-6-(4-methoxyphenyl)hexa-2,4-dienamide

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID311988	Antifungal activity against Cladosporium sphaerospermum after 72 hrs	2007	Journal of natural products, Dec, Volume: 70, Issue:12	Antifungal amides from Piper scutifolium and Piper hoffmanseggianum.
AID311989	Antifungal activity against Cladosporium cladosporioides after 72 hrs	2007	Journal of natural products, Dec, Volume: 70, Issue:12	Antifungal amides from Piper scutifolium and Piper hoffmanseggianum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (16.67)	18.7374
1990's	1 (16.67)	18.2507
2000's	2 (33.33)	29.6817
2010's	2 (33.33)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	2.03	1	dichlorobenzene; ether; imidazoles
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	2.01	1
piplartine piplartine: Antineoplastic Agent, Phytogenic; alkaloid from Piper; structure in first source	2.08	1	cinnamamides; dicarboximide
sorbic acid Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.. (2E,4E)-hexa-2,4-dienoic acid : A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometric isomers possible, as well as the one with the highest antimicrobial activity.. sorbic acid : A hexadienoic acid with double bonds at C-2 and C-4; it has four geometrical isomers, of which the trans,trans-form is naturally occurring.	3.11	5	alpha,beta-unsaturated monocarboxylic acid; sorbic acid
piperlonguminine piperlonguminine: from Piper longum; structure in first source	2.03	1	benzodioxoles
tetrodotoxin Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.	2.01	1	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker
nystatin a1 Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.	2.03	1	nystatins

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