| Protein | Synonyms | Taxonomy |
|---|
| 2-alpha-hydroxytaxane 2-O-benzoyltransferase | TBT; EC 2.3.1.166; 2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase; DBBT | Taxus cuspidata |
| Taxadien-5-alpha-ol O-acetyltransferase | EC 2.3.1.162; Taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase; Taxadienol acetyltransferase | Taxus cuspidata |
| 10-deacetylbaccatin III 10-O-acetyltransferase | DBAT; EC 2.3.1.167 | Taxus cuspidata |
| Taxadiene synthase | EC 4.2.3.17; Taxa-4(5),11(12)-diene synthase | Taxus brevifolia |
| Taxane 10-beta-hydroxylase | EC 1.14.14.105; 5-alpha-taxadienol-10-beta-hydroxylase; Cytochrome P450 725A1 | Taxus cuspidata |
| Taxoid 14-beta-hydroxylase | EC 1.14.13.146; Taxane 14b-hydroxylase | Taxus cuspidata |
| Phenylpropanoyltransferase | | Taxus cuspidata |
| 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase | DBTNBT; EC 2.3.1.- | Taxus canadensis |
| Taxane 13-alpha-hydroxylase | EC 1.14.14.106; Cytochrome P450 725A2 | Taxus cuspidata |
| Taxadiene 5-alpha hydroxylase | EC 1.14.14.176 | Taxus cuspidata |
| Compound | Description |
|---|
| diphosphoric acid | |
| hydronium ion | |
| paclitaxel | A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| geranylgeranyl pyrophosphate | RN given refers to (E,E,E)-isomer |
| 10-deacetylbaccatine iii | structure given in first source |
| Coenzyme A | |
| taxadiene | |
| Acetyl Coenzyme A | Acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent. |
| benzoyl-coenzyme A | RN given refers to unlabeled cpd |
| baccatin iii | from Taxus yunnanensis; structure given in first source |