Page last updated: 2024-10-24

homoiothermy

Definition

Target type: biologicalprocess

Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. [ISBN:0192801023]

Homoiothermy, also known as warm-bloodedness, is a physiological state that allows organisms to maintain a stable internal body temperature regardless of external environmental fluctuations. This is a key characteristic of mammals and birds, distinguishing them from other animal groups like reptiles, amphibians, and fish. The ability to regulate internal temperature is achieved through a complex interplay of physiological mechanisms.

**1. Metabolic Heat Production:** Homoiothermic animals generate internal heat through their metabolic processes. This heat is primarily derived from cellular respiration, where energy is extracted from food molecules. The rate of metabolism, and thus heat production, can be adjusted based on environmental conditions. For instance, shivering is a behavioral response to cold temperatures that increases muscle activity and heat generation.

**2. Insulation:** To minimize heat loss to the environment, homoiothermic animals have evolved various insulation mechanisms. These include fur, feathers, subcutaneous fat layers, and even specialized blood vessel arrangements that reduce heat transfer through the skin.

**3. Thermoregulation:** The maintenance of a stable internal temperature is a dynamic process controlled by the hypothalamus, a region in the brain. Sensory receptors in the skin and internal organs monitor body temperature and relay this information to the hypothalamus. The hypothalamus then activates physiological responses to adjust heat loss or gain, such as sweating to cool down or vasoconstriction to conserve heat.

**4. Behavioral Adaptations:** In addition to physiological mechanisms, homoiothermic animals exhibit behavioral adaptations to regulate their temperature. These include seeking shade or basking in the sun, huddling together for warmth, and adjusting their activity levels based on the time of day or season.

**5. Advantages of Homoiothermy:**

* **Enhanced Activity:** Stable internal temperatures allow homoiothermic animals to maintain high levels of activity regardless of external conditions, facilitating efficient hunting, foraging, and reproduction.
* **Wider Geographic Distribution:** Homoiothermy allows organisms to thrive in a broader range of habitats, including cold climates where ectotherms (cold-blooded animals) would struggle to survive.
* **Increased Metabolic Rate:** The ability to maintain high internal temperatures allows for a faster metabolic rate, which in turn supports complex behaviors and cognitive abilities.

**6. Energy Costs:** The maintenance of homoiothermy requires significant energy expenditure. This is a major evolutionary trade-off, as homoiothermic animals need to consume more food to fuel their higher metabolic rates.'
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Proteins (2)

ProteinDefinitionTaxonomy
Melanocortin receptor 3A melanocortin receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41968]Homo sapiens (human)
Dopamine beta-hydroxylaseA dopamine beta-hydroxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09172]Homo sapiens (human)

Compounds (22)

CompoundDefinitionClassesRoles
amiodaroneamiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.

Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
1-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound
cardiovascular drug
astemizoleastemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.

Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects.
benzimidazoles;
piperidines
anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist
chlorpromazinechlorpromazine : A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Chlorpromazine: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
organochlorine compound;
phenothiazines;
tertiary amine
anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
econazole1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.

econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.

Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.
dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
hypericin
miconazole1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.

miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.

Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
dichlorobenzene;
ether;
imidazoles
tropolonetropolone : A cyclic ketone that is cyclohepta-2,4,6-trien-1-one substituted by a hydroxy group at position 2. It is a toxin produced by the agricultural pathogen Burkholderia plantarii.

Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).
alpha-hydroxy ketone;
cyclic ketone;
enol
bacterial metabolite;
fungicide;
toxin
u 0521U 0521: catechol methyltransferase antagonist; structureacetophenones
7-hydroxytropolone7-hydroxytropolone: structure
melanotan-iimelanotan-II: synthetic cyclic heptapeptide, an analog of alpha-melanotropin (4,10); capable of stimulating melanin synthesis & promoting rapid tanning of skin; currently in trials for use in the prevention of sunlight-induced skin cancerorganic molecular entity
3,7-dihydroxytropolone3,7-dihydroxytropolone : A cyclic ketone that is tropolone in which the hydrogens at positions 3 and 7 are substituted by hydroxy groups. It is isolated from the soil bacterium Streptomyces tropolofaciens strain K611-97.

3,7-dihydroxytropolone: from Streptomyces tropolofaciens; active against B16 melanoma; structure given in first source
alpha-hydroxy ketone;
cyclic ketone;
enol;
triol
antineoplastic agent;
bacterial metabolite
tamoxifenstilbenoid;
tertiary amino compound
angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
1-(4-hydroxybenzyl)imidazole-2-thiol1-(4-hydroxybenzyl)imidazole-2-thiol: RN & structure given in first source; RN not in Chemline 3/87
shu 9119SHU 9119: an agouti mimetic; structure in first source
bremelanotidebremelanotide: a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system;oligopeptide
sk&f 102698
acetyl-histidyl-phenylalanyl-arginyl-tryptophanamide
ac-his-dphe-arg-trp-nh2
rm-493setmelanotide: an anti-obesity agent
alpha-mshpeptide hormoneanti-inflammatory agent
msh, 4-nle-7-phe-alpha-polypeptidedermatologic drug
nitd 609NITD 609: an antimalarial and coccidiostat; structure in first source