ptilomycalin a profile

ptilomycalin A: a polycyclic guanidine alkaloid from the marine sponge Ptilocaulis spiculifer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	46882529
CHEMBL ID	1077545
MeSH ID	M0269902

Synonym
ptilomycalin a
CHEMBL1077545
Q15424788

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Laccase	Trametes versicolor	IC50 (µMol)	5.1333	4.7000	5.1333	5.8000	AID628706; AID628708; AID628709
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (24)

Assay ID	Title	Year	Journal	Article
AID628623	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as onset day of melanization at 0.2 uM by drop test assay in presence of 1 mM L-dopa (Rvb = 6 days)	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628703	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as onset day of melanization at 0.6 uM by drop test assay in presence of 1 mM L-dopa (Rvb = 6 days)	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628704	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as onset day of melanization at 2 uM by drop test assay in presence of 1 mM L-dopa (Rvb = 6 days)	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628710	Antimelanogenic activity in Cryptococcus neoformans var. grubii assessed as halo diameter surrounded by non-melanized cells at 10 ug after 6 days by halo assay in presence of 1 mM L-dopa	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628712	Antimelanogenic activity in Cryptococcus neoformans var. gattii assessed as halo diameter surrounded by non-melanized cells at 10 ug after 6 days by halo assay in presence of 1 mM L-dopa	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID472335	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as inhibition of [G-3H]hypoxanthine incorporation after 24 hrs by scintillation counting	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Bioactive guanidine alkaloids from two Caribbean marine sponges.
AID628621	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as inhibition of pigmentation at 0.8 ug/mL after 21 days by microtiter plate assay in presence of 1 mM catecholamine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628622	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as onset day of melanization at 0.06 uM by drop test assay in presence of 1 mM L-dopa (Rvb = 6 days)	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628611	Antimelanogenic activity in Cryptococcus neoformans var. gattii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of L-dopa	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628708	Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 200 uM dopamine as substrate preincubated for 30 mins before substrate addition	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID472337	Cytotoxicity against african green monkey Vero cells	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Bioactive guanidine alkaloids from two Caribbean marine sponges.
AID628609	Antimelanogenic activity in Cryptococcus neoformans var. grubii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of epinephrine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628706	Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 100 uM epinephrine as substrate preincubated for 30 mins before substrate addition	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628709	Inhibition of Trametes versicolor laccase assessed as production of dopachrome using 300 uM L-dopa as substrate preincubated for 30 mins before substrate addition	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628705	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as delay of melanization by drop test assay in presence of 1 mM L-dopa	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628618	Antimelanogenic activity in non-melanized Cryptococcus neoformans var. grubii assessed as inhibition of pigmentation at 0.8 ug/mL after 10 days by microtiter plate assay in presence of 1 mM catecholamine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID472336	Selective index, ratio of TC50 for human HeLa cells to IC50 for Plasmodium falciparum FcB1/Columbia	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Bioactive guanidine alkaloids from two Caribbean marine sponges.
AID628565	Antimelanogenic activity in Cryptococcus neoformans var. grubii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of L-dopa	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628615	Antimelanogenic activity in Cryptococcus neoformans var. gattii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of epinephrine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628707	Inhibition of laccase in Cryptococcus neoformans var. grubii assessed as production of dopachrome using 100 uM epinephrine as substrate preincubated for 30 mins before substrate addition	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628714	Inhibition of DNA polymerase activity of HIV reverse transcriptase at 10 uM	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628607	Antimelanogenic activity in Cryptococcus neoformans var. grubii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of dopamine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID628613	Antimelanogenic activity in Cryptococcus neoformans var. gattii assessed as halo diameter surrounded by non-melanized cells at 20 ug after 6 to 8 days by halo assay in presence of dopamine	2011	Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22	Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.
AID472334	Cytotoxicity against human HeLa cells by sulforhodamine B assay	2009	Journal of natural products, Sep, Volume: 72, Issue:9	Bioactive guanidine alkaloids from two Caribbean marine sponges.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	5 (62.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2.01	1	amino-acid anion
spermidine [no description available]	2.01	1	polyazaalkane; triamine	autophagy inducer; fundamental metabolite; geroprotector
glyphosate glyphosate: active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure. glyphosate : A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).	2.06	1	glycine derivative; phosphonic acid	agrochemical; EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor; herbicide
guanidine Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.	2.73	3	carboxamidine; guanidines; one-carbon compound
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	2.06	1	dichlorobenzene; ether; imidazoles
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.01	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
sodium azide Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).	2.06	1	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen
batzelladine d batzelladine D: structure in first source	2.02	1
batzelladine f batzelladine F: structure in first source	2.02	1
laccase Laccase: A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.	7.06	1
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.06	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
batzelladine a batzelladine A: strucutre in first source. batzelladine A : A carboxylic ester obtained by the formal condensation of (2aS,3S,4R,7R,8aS)-4-methyl-7-nonyl-2,2a,3,4,6,7,8,8a-octahydro-1H-5,6,8b-triazaacenaphthylene-3-carboxylic acid with the hydroxy group of 4-carbamimidamidobutyl (3R)-3-(9-hydroxynonyl)-1-imino-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carboxylate. Isolated from a bright red Caribbean sponge, Batzella, it has potential anti-HIV activity.	2.44	2	alkaloid; carboxylic ester; guanidines; organic heterotricyclic compound; pyrrolopyrimidine; triazaacenaphthylene	anti-HIV-1 agent; metabolite
monanchocidin monanchocidin: from the marine sponge Monanchora; structure in first source	2.13	1	organic molecular entity	metabolite
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	2.13	1

Condition	Relationship Strength	Studies
C gattii Infection [description not available]	2.06	1
Cryptococcosis Fungal infection caused by genus CRYPTOCOCCUS.	2.06	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.13	1

ptilomycalin a

Description

Cross-References

Synonyms (3)

Protein Targets (1)

Inhibition Measurements

Bioassays (24)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.73

Study Types

ptilomycalin a

Description

Cross-References

Synonyms (3)

Protein Targets (1)

Inhibition Measurements

Bioassays (24)

Research

Studies (8)

Market Indicators

Research Demand Index: 12.73

Study Types

Related Drugs (14)

Related Conditions (3)