miconazole has been researched along with Leukemia in 15 studies
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effectiveness of miconazole was evaluated in 9 documented fungal infections, 4 of which were candidal sepsis." | 3.67 | [Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies]. ( Nagai, K; Nakayama, S; Yabe, H; Yoshida, T, 1984) |
| "Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions." | 3.66 | Cardiorespiratory toxicity due to miconazole. ( Bodey, GP; Fainstein, V, 1980) |
| "In 24 patients with advanced malignant diseases, mainly leukaemias and lymphomas, 35 episodes of oral candidiasis were treated with topical application of miconazole." | 3.65 | Treatment of oral candidiasis in debilitated patients with miconazole--a new potent antifungal drug. ( Brincker, H, 1976) |
| "The miconazole-treated patients remained clinically free of mycosis for 252 out of 264 treatment days, while the placebo-treated patients remained free of mycosis for only 263 out or 338 treatment days (p = 0." | 2.64 | Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study. ( Brincker, H, 1978) |
| "Disseminated candidiasis is likely to become an increasing problem in cancer patients." | 1.27 | Candidiasis in cancer patients. ( Bodey, GP, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bodey, GP | 3 |
| Maksymiuk, AW | 1 |
| Thongprasert, S | 1 |
| Hopfer, R | 1 |
| Luna, M | 1 |
| Fainstein, V | 2 |
| Nagai, K | 1 |
| Yabe, H | 1 |
| Yoshida, T | 1 |
| Nakayama, S | 1 |
| Chubachi, A | 2 |
| Miura, I | 2 |
| Ohshima, A | 2 |
| Nishinari, T | 1 |
| Nimura, T | 2 |
| Niitsu, H | 2 |
| Miura, AB | 2 |
| Myoken, Y | 2 |
| Sugata, T | 1 |
| Kyo, T | 1 |
| Fujihara, M | 1 |
| Mikami, Y | 1 |
| Brincker, H | 3 |
| Michaux, JL | 1 |
| Jacquemin, P | 1 |
| Cornu, G | 1 |
| Wauters, G | 1 |
| Gigi, J | 1 |
| Noel, H | 1 |
| Turine, JB | 1 |
| Ferrant, A | 2 |
| Grulich, M | 1 |
| Dörffel, W | 1 |
| Reuter, G | 1 |
| Gemeinhardt, H | 1 |
| Stuchlik, S | 1 |
| De Beule, F | 1 |
| Bercy, P | 1 |
| Verhagen, C | 1 |
| Stalpers, LJ | 1 |
| de Pauw, BE | 1 |
| Haanen, C | 1 |
1 trial available for miconazole and Leukemia
| Article | Year |
|---|---|
Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Candida; Clinical Trials as Topic; Double- | 1978 |
14 other studies available for miconazole and Leukemia
| Article | Year |
|---|---|
Candidiasis in cancer patients.
Topics: Amphotericin B; Antibodies, Fungal; Candidiasis; Cephalosporins; Humans; Ketoconazole; Leukemia; Mic | 1984 |
Systemic candidiasis in cancer patients.
Topics: Acute Disease; Amphotericin B; Bacterial Infections; Bacteriological Techniques; Candida; Candidiasi | 1984 |
[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies].
Topics: Adolescent; Adult; Aged; Candidiasis; Drug Evaluation; Esophagitis; Female; Hodgkin Disease; Humans; | 1984 |
Cardiorespiratory toxicity due to miconazole.
Topics: Adult; Anaphylaxis; Female; Heart Arrest; Humans; Imidazoles; Leukemia; Male; Miconazole; Middle Age | 1980 |
Risk factors for hepatosplenic abscesses in patients with acute leukemia receiving empiric azole treatment.
Topics: Abscess; Acute Disease; Adolescent; Adult; Aged; Candidiasis; Female; Fever; Fluconazole; Humans; Le | 1994 |
Notable clinical changes of hepatosplenic abscesses in febrile neutropenic patients receiving empiric antifungal treatment with azoles.
Topics: Abscess; Antifungal Agents; Candidiasis; Fever; Fluconazole; Humans; Leukemia; Liver Abscess; Lympho | 1994 |
Antifungal susceptibility of Aspergillus species isolated from invasive oral infection in neutropenic patients with hematologic malignancies.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Aspergillosis; Aspergillus; D | 1999 |
Miconazole in oral candidiasis.
Topics: Administration, Oral; Candidiasis, Oral; Humans; Leukemia; Miconazole; Middle Aged; Tablets | 1977 |
Use of miconazole for prevention of opportunistic fungal infection during treatment of haematological malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Leukemia; Male; Miconazole; Middl | 1977 |
[Experiences with miconazole in the prevention and therapy of candidiasis].
Topics: Candidiasis; Child; Drug Evaluation; Humans; Imidazoles; Leukemia; Miconazole | 1979 |
[Treatment of mouth candidiasis in leukemia patients with parenterally administered miconazole].
Topics: Adult; Bronchial Diseases; Candidiasis, Oral; Chemical Phenomena; Chemistry; Female; Humans; Imidazo | 1975 |
Treatment of oral candidiasis in debilitated patients with miconazole--a new potent antifungal drug.
Topics: Administration, Topical; Adolescent; Adult; Aged; Candidiasis, Oral; Drug Evaluation; Female; Humans | 1976 |
The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma.
Topics: Acyclovir; Amphotericin B; Ceftazidime; Chlorhexidine; Dental Plaque Index; Fluconazole; Humans; Imm | 1991 |
Drug-induced skin reactions in patients with acute non-lymphocytic leukaemia.
Topics: Acute Disease; Adult; Allopurinol; Cephalosporins; Drug Combinations; Drug Eruptions; Female; Humans | 1987 |