Page last updated: 2024-10-31

miconazole and Leukemia

miconazole has been researched along with Leukemia in 15 studies

Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"The effectiveness of miconazole was evaluated in 9 documented fungal infections, 4 of which were candidal sepsis."3.67[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies]. ( Nagai, K; Nakayama, S; Yabe, H; Yoshida, T, 1984)
"Seven patients with hematologic malignancies who were treated with miconazole for either suspected or proven fungal infections developed eight episodes of major adverse cardiorespiratory and anaphylactic reactions."3.66Cardiorespiratory toxicity due to miconazole. ( Bodey, GP; Fainstein, V, 1980)
"In 24 patients with advanced malignant diseases, mainly leukaemias and lymphomas, 35 episodes of oral candidiasis were treated with topical application of miconazole."3.65Treatment of oral candidiasis in debilitated patients with miconazole--a new potent antifungal drug. ( Brincker, H, 1976)
"The miconazole-treated patients remained clinically free of mycosis for 252 out of 264 treatment days, while the placebo-treated patients remained free of mycosis for only 263 out or 338 treatment days (p = 0."2.64Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study. ( Brincker, H, 1978)
"Disseminated candidiasis is likely to become an increasing problem in cancer patients."1.27Candidiasis in cancer patients. ( Bodey, GP, 1984)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199011 (73.33)18.7374
1990's4 (26.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bodey, GP3
Maksymiuk, AW1
Thongprasert, S1
Hopfer, R1
Luna, M1
Fainstein, V2
Nagai, K1
Yabe, H1
Yoshida, T1
Nakayama, S1
Chubachi, A2
Miura, I2
Ohshima, A2
Nishinari, T1
Nimura, T2
Niitsu, H2
Miura, AB2
Myoken, Y2
Sugata, T1
Kyo, T1
Fujihara, M1
Mikami, Y1
Brincker, H3
Michaux, JL1
Jacquemin, P1
Cornu, G1
Wauters, G1
Gigi, J1
Noel, H1
Turine, JB1
Ferrant, A2
Grulich, M1
Dörffel, W1
Reuter, G1
Gemeinhardt, H1
Stuchlik, S1
De Beule, F1
Bercy, P1
Verhagen, C1
Stalpers, LJ1
de Pauw, BE1
Haanen, C1

Trials

1 trial available for miconazole and Leukemia

ArticleYear
Prophylactic treatment with miconazole in patients highly predisposed to fungal infection. A placebo-controlled double-blind study.
    Acta medica Scandinavica, 1978, Volume: 204, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Candida; Clinical Trials as Topic; Double-

1978

Other Studies

14 other studies available for miconazole and Leukemia

ArticleYear
Candidiasis in cancer patients.
    The American journal of medicine, 1984, Oct-30, Volume: 77, Issue:4D

    Topics: Amphotericin B; Antibodies, Fungal; Candidiasis; Cephalosporins; Humans; Ketoconazole; Leukemia; Mic

1984
Systemic candidiasis in cancer patients.
    The American journal of medicine, 1984, Oct-30, Volume: 77, Issue:4D

    Topics: Acute Disease; Amphotericin B; Bacterial Infections; Bacteriological Techniques; Candida; Candidiasi

1984
[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies].
    The Japanese journal of antibiotics, 1984, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Aged; Candidiasis; Drug Evaluation; Esophagitis; Female; Hodgkin Disease; Humans;

1984
Cardiorespiratory toxicity due to miconazole.
    Annals of internal medicine, 1980, Volume: 93, Issue:3

    Topics: Adult; Anaphylaxis; Female; Heart Arrest; Humans; Imidazoles; Leukemia; Male; Miconazole; Middle Age

1980
Risk factors for hepatosplenic abscesses in patients with acute leukemia receiving empiric azole treatment.
    The American journal of the medical sciences, 1994, Volume: 308, Issue:6

    Topics: Abscess; Acute Disease; Adolescent; Adult; Aged; Candidiasis; Female; Fever; Fluconazole; Humans; Le

1994
Notable clinical changes of hepatosplenic abscesses in febrile neutropenic patients receiving empiric antifungal treatment with azoles.
    European journal of haematology, 1994, Volume: 52, Issue:4

    Topics: Abscess; Antifungal Agents; Candidiasis; Fever; Fluconazole; Humans; Leukemia; Liver Abscess; Lympho

1994
Antifungal susceptibility of Aspergillus species isolated from invasive oral infection in neutropenic patients with hematologic malignancies.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1999, Volume: 87, Issue:2

    Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Antineoplastic Agents; Aspergillosis; Aspergillus; D

1999
Miconazole in oral candidiasis.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 1

    Topics: Administration, Oral; Candidiasis, Oral; Humans; Leukemia; Miconazole; Middle Aged; Tablets

1977
Use of miconazole for prevention of opportunistic fungal infection during treatment of haematological malignancies.
    Proceedings of the Royal Society of Medicine, 1977, Volume: 70 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Leukemia; Male; Miconazole; Middl

1977
[Experiences with miconazole in the prevention and therapy of candidiasis].
    Padiatrie und Grenzgebiete, 1979, Volume: 18, Issue:3

    Topics: Candidiasis; Child; Drug Evaluation; Humans; Imidazoles; Leukemia; Miconazole

1979
[Treatment of mouth candidiasis in leukemia patients with parenterally administered miconazole].
    Die Medizinische Welt, 1975, Jun-20, Volume: 26, Issue:25

    Topics: Adult; Bronchial Diseases; Candidiasis, Oral; Chemical Phenomena; Chemistry; Female; Humans; Imidazo

1975
Treatment of oral candidiasis in debilitated patients with miconazole--a new potent antifungal drug.
    Scandinavian journal of infectious diseases, 1976, Volume: 8, Issue:2

    Topics: Administration, Topical; Adolescent; Adult; Aged; Candidiasis, Oral; Drug Evaluation; Female; Humans

1976
The effectiveness of a preventive regimen on the periodontal health of patients undergoing chemotherapy for leukemia and lymphoma.
    Journal of clinical periodontology, 1991, Volume: 18, Issue:5

    Topics: Acyclovir; Amphotericin B; Ceftazidime; Chlorhexidine; Dental Plaque Index; Fluconazole; Humans; Imm

1991
Drug-induced skin reactions in patients with acute non-lymphocytic leukaemia.
    European journal of haematology, 1987, Volume: 38, Issue:3

    Topics: Acute Disease; Adult; Allopurinol; Cephalosporins; Drug Combinations; Drug Eruptions; Female; Humans

1987