miconazole has been researched along with Electrocardiogram QT Prolonged in 2 studies
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Miconazole, an imidazole antifungal agent, is associated with acquired long QT syndrome and ventricular arrhythmias." | 3.73 | Blockade of HERG cardiac K+ current by antifungal drug miconazole. ( Abe, H; Duff, HJ; January, CT; Kawakami, K; Kikuchi, K; Makielski, JC; Nagatomo, T; Nakashima, Y, 2005) |
| "disopyramide was administered intra-vascularly in separate experiments, and the doses were predicted only from the pharmacological data." | 1.31 | Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat. ( Iwanaga, K; Kakemi, M; Maekawa, C; Miyazaki, M; Morimoto, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, K | 1 |
| Nagatomo, T | 1 |
| Abe, H | 1 |
| Kawakami, K | 1 |
| Duff, HJ | 1 |
| Makielski, JC | 1 |
| January, CT | 1 |
| Nakashima, Y | 1 |
| Miyazaki, M | 1 |
| Maekawa, C | 1 |
| Iwanaga, K | 1 |
| Morimoto, K | 1 |
| Kakemi, M | 1 |
2 other studies available for miconazole and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Blockade of HERG cardiac K+ current by antifungal drug miconazole.
Topics: Action Potentials; Antifungal Agents; Cell Line; Dose-Response Relationship, Drug; ERG1 Potassium Ch | 2005 |
Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat.
Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Antifungal Agents; Area Under Curve; Biological Availab | 2000 |