miconazole has been researched along with Agranulocytosis in 4 studies
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients treated with cytotoxic therapy expected to produce neutropenia lasting two or more weeks were randomly assigned in a double-blind study to receive intravenous miconazole or placebo concomitant with empiric antibiotics to test whether miconazole can prevent fungal sepsis." | 9.06 | Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole. ( Braine, HG; Merz, WG; Saral, R; Vaughan, WP; Wingard, JR, 1987) |
| "Patients treated with cytotoxic therapy expected to produce neutropenia lasting two or more weeks were randomly assigned in a double-blind study to receive intravenous miconazole or placebo concomitant with empiric antibiotics to test whether miconazole can prevent fungal sepsis." | 5.06 | Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole. ( Braine, HG; Merz, WG; Saral, R; Vaughan, WP; Wingard, JR, 1987) |
| "Ketoconazole or miconazole was randomly administered to 42 and 46 neutropenic patients respectively." | 2.65 | Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients. ( Cruciani, M; Klastersky, J; Meunier-Carpentier, F, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meunier-Carpentier, F | 1 |
| Cruciani, M | 1 |
| Klastersky, J | 1 |
| Sotoyama, K | 1 |
| Wiley, JM | 1 |
| Smith, N | 1 |
| Leventhal, BG | 1 |
| Graham, ML | 1 |
| Strauss, LC | 1 |
| Hurwitz, CA | 1 |
| Modlin, J | 1 |
| Mellits, D | 1 |
| Baumgardner, R | 1 |
| Corden, BJ | 1 |
| Wingard, JR | 1 |
| Vaughan, WP | 1 |
| Braine, HG | 1 |
| Merz, WG | 1 |
| Saral, R | 1 |
2 trials available for miconazole and Agranulocytosis
| Article | Year |
|---|---|
Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients.
Topics: Agranulocytosis; Antifungal Agents; Candidiasis; Drug Combinations; Female; Humans; Imidazoles; Keto | 1983 |
Prevention of fungal sepsis in patients with prolonged neutropenia: a randomized, double-blind, placebo-controlled trial of intravenous miconazole.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Amphotericin B; Bacterial Infections; Bone Marrow Transpla | 1987 |
2 other studies available for miconazole and Agranulocytosis
| Article | Year |
|---|---|
[Countermeasure for infections with granulocytopenia].
Topics: Agranulocytosis; Aminoglycosides; Anti-Bacterial Agents; Candidiasis; Cephalosporins; Drug Therapy, | 1992 |
Invasive fungal disease in pediatric acute leukemia patients with fever and neutropenia during induction chemotherapy: a multivariate analysis of risk factors.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Pr | 1990 |