miconazole has been researched along with Long QT Syndrome in 2 studies
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Miconazole, an imidazole antifungal agent, is associated with acquired long QT syndrome and ventricular arrhythmias." | 3.73 | Blockade of HERG cardiac K+ current by antifungal drug miconazole. ( Abe, H; Duff, HJ; January, CT; Kawakami, K; Kikuchi, K; Makielski, JC; Nagatomo, T; Nakashima, Y, 2005) |
| "disopyramide was administered intra-vascularly in separate experiments, and the doses were predicted only from the pharmacological data." | 1.31 | Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat. ( Iwanaga, K; Kakemi, M; Maekawa, C; Miyazaki, M; Morimoto, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, K | 1 |
| Nagatomo, T | 1 |
| Abe, H | 1 |
| Kawakami, K | 1 |
| Duff, HJ | 1 |
| Makielski, JC | 1 |
| January, CT | 1 |
| Nakashima, Y | 1 |
| Miyazaki, M | 1 |
| Maekawa, C | 1 |
| Iwanaga, K | 1 |
| Morimoto, K | 1 |
| Kakemi, M | 1 |
2 other studies available for miconazole and Long QT Syndrome
| Article | Year |
|---|---|
Blockade of HERG cardiac K+ current by antifungal drug miconazole.
Topics: Action Potentials; Antifungal Agents; Cell Line; Dose-Response Relationship, Drug; ERG1 Potassium Ch | 2005 |
Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat.
Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Antifungal Agents; Area Under Curve; Biological Availab | 2000 |