Target type: cellularcomponent
A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth. [GOC:expert_jd, GOC:mah, PMID:19431238]
The apical tip of a newly growing cell, often referred to as the "growing point," is a dynamic and intricate structure. It is characterized by a high concentration of specialized organelles and molecules, all working in concert to drive cell elongation and expansion.
**Key Cellular Components:**
- **Plasma membrane:** The outer boundary of the cell, it actively participates in the uptake of nutrients and the secretion of cell wall components, essential for growth. It is also responsible for maintaining the turgor pressure within the cell, pushing against the cell wall to enable elongation.
- **Cell Wall:** A rigid, yet flexible, structure that provides structural support and protection to the cell. It is continuously synthesized at the apical tip, with new wall material being deposited in a precise and regulated manner. This process involves a complex interplay of enzymes, proteins, and polysaccharides.
- **Microtubules:** These dynamic, protein-based filaments play a crucial role in shaping the cell and guiding the movement of organelles. In the apical tip, microtubules form a network that directs the deposition of cell wall material and the distribution of other essential components, contributing to the overall direction of growth.
- **Actin Filaments:** Another type of cytoskeletal filament, actin filaments are involved in the transport of vesicles and organelles, including those containing cell wall components. They also play a role in the formation of the tip growth zone, where new cell wall material is actively being deposited.
- **Golgi apparatus:** This organelle is responsible for processing and packaging proteins and other molecules, including those needed for cell wall formation. It receives materials from the endoplasmic reticulum and sends out vesicles that fuse with the plasma membrane, releasing their contents to the cell wall.
- **Endoplasmic reticulum (ER):** This network of interconnected membranes plays a crucial role in protein synthesis, modification, and transport. It also synthesizes lipids and other components needed for cell growth.
- **Vacuole:** This large, fluid-filled organelle occupies a significant portion of the cell's volume. It is involved in maintaining turgor pressure, storing nutrients and waste products, and playing a role in cell growth regulation.
- **Nucleus:** The control center of the cell, the nucleus contains the cell's DNA and directs the synthesis of proteins needed for cell growth.
- **Ribosomes:** These small, protein-synthesizing organelles are abundant in the apical tip, reflecting the high rate of protein synthesis needed for cell growth.
**Dynamic Processes:**
- **Tip Growth:** The apical tip is the site of active cell wall synthesis and extension, leading to the elongation of the cell. This process is highly regulated and involves a complex interplay of the cellular components mentioned above.
- **Polarity:** The apical tip is a highly polarized structure, with a distinct "leading edge" where growth occurs and a "trailing edge" where the cell wall is being deposited. This polarity is established and maintained by a complex network of signaling pathways and cellular components.
- **Signaling Pathways:** Numerous signaling pathways control the processes of cell growth and development at the apical tip. These pathways involve the interaction of hormones, proteins, and other molecules, ensuring the coordinated and regulated growth of the cell.'
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Protein | Definition | Taxonomy |
---|---|---|
Metabotropic glutamate receptor 6 | A metabotropic glutamate receptor 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15303] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
2-amino-4-phosphonobutyric acid | 2-amino-4-phosphonobutyric acid: glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version | ||
miconazole | 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes. Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion. | dichlorobenzene; ether; imidazoles | |
aspartic acid | aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. L-aspartic acid : The L-enantiomer of aspartic acid. | aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; mouse metabolite; neurotransmitter |
kainic acid | Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose. | dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid | antinematodal drug; excitatory amino acid agonist |
d-glutamate | D-alpha-amino acid; glutamic acid | Escherichia coli metabolite; mouse metabolite | |
glutamic acid | glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical |
quisqualic acid | Quisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis. | non-proteinogenic alpha-amino acid | |
d-aspartic acid | aspartic acid; D-alpha-amino acid | mouse metabolite | |
L-2-aminoadipic acid | L-2-aminoadipic acid : The L-enantiomer of 2-aminoadipic acid. | 2-aminoadipic acid | Escherichia coli metabolite; human metabolite |
sym 2081 | |||
alpha-aminopimelic acid | 2-aminopimelic acid : An amino dicarboxylic acid that is heptanedioic acid in which a hydrogen at position 2 is replaced by an amino group. It is a component of the cell wall peptidoglycan of bacteria. alpha-aminopimelic acid: antagonizes glutamate-induced inhibitions of Helix neurones | amino dicarboxylic acid; non-proteinogenic alpha-amino acid | bacterial metabolite |
1-amino-1,3-dicarboxycyclopentane | 1-amino-1,3-dicarboxycyclopentane: RN given refers to (cis)-isomer | ||
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | |||
alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid | alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid: RN given refers to cpd without isomeric designation; structure given in first source | ||
2-amino-4-phosphonobutyric acid | (2S)-2-amino-4-phosphonobutanoic acid : A non-proteinogenc L-alpha-amino acid that is L-alpha-aminobutyric acid in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group. It is a potent and selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). | non-proteinogenic L-alpha-amino acid; phosphonic acids | metabotropic glutamate receptor agonist |
eglumetad | eglumetad: LY-354740 is the active isomer, LY-366563 is the inactive isomer, and LY 314582 is the racemate; structure given in first source | L-alpha-amino acid | |
6-methyl-2-(phenylethynyl)pyridine | 2-methyl-6-(phenylethynyl)pyridine : A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. 6-methyl-2-(phenylethynyl)pyridine: an mGlu5 antagonist | acetylenic compound; methylpyridines | anxiolytic drug; metabotropic glutamate receptor antagonist |
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline: structure given in first source; neuroprotectant for cerebral ischemia; AMPA receptor antagonist | naphthalenes; sulfonic acid derivative | |
sib 1757 | SIB 1757: a selective mGluR5 antagonist; structure in first source | ||
l-2-(carboxypropyl)glycine | |||
2-(2,3-dicarboxycyclopropyl)glycine | |||
2r,4r-4-aminopyrrolidine-2,4-dicarboxylate | pyrrolidinedicarboxylic acid | ||
sib 1893 | SIB 1893: a selective mGluR5 antagonist; structure in first source | ||
ampa, (r)-isomer | |||
1-aminocyclopentane-1,3,4-tricarboxylic acid | 1-aminocyclopentane-1,3,4-tricarboxylic acid: metabolic glutamate receptor (mGluR) antagonist; structure in first source | ||
mgs 0028 | MGS 0028: a group II mGluR agonist; structure in first source | ||
ly 389795 | LY 389795: a group II metabotropic glutamate receptor agonist; structure in first source | ||
ly 379268 | LY 379268 : An organic heterobicyclic compound that is (1R,5S)-2-oxabicyclo[3.1.0]hexane carrying amino, carboxy, and carboxy groups at positions 4R, 4R and 6R, respectively. It is a potent agonist of group II metabotropic glutamate receptors mGluR2 and mGluR3 (EC50 = 2.69 nM and 4.48 nM, respectively) that exhibits antipsychotic-like action in animal models of schizophrenia. LY 379268: group II metabotropic glutamate receptor agonist; structure in first source | amino dicarboxylic acid; bridged compound; organic heterobicyclic compound | antipsychotic agent; anxiolytic drug; metabotropic glutamate receptor agonist; neuroprotective agent |
3,4-dicarboxyphenylglycine | |||
sp 203 | 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile: a radioligand for mGlu5 receptor; structure in first source | ||
lsp4-2022 | LSP4-2022: structure in first source |