| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1503034 | Cytotoxicity in human HEK293T cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503048 | Reduction in GSH/GSSG ratio in human HL60 cells at 1 to 5 uM incubated for 24 hrs by enzymatic recycling method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503040 | Inhibition of TrxR1 in human HL60 cells incubated for 12 hrs by TRFS-green dye based fluorescence assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503039 | Inhibition of NADPH-reduced rat glutathione reductase at 1 to 5 uM incubated for 1 hr in presence of NADPH and GSSG | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503045 | Induction of ROS production in human HL60 cells at 1 to 5 uM incubated for 1 hr by DCFH-DA staining based fluorescence assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503032 | Cytotoxicity in human A549 cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503062 | Induction of apoptosis in human HL60 cells 0.5 to 5 uM incubated for 24 hrs in presence of NAC by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503026 | Cytotoxicity in HEK293T cells overexpressing TrxR1 (unknown origin) cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503061 | Induction of apoptosis in human HL60 cells 5 uM incubated for 24 hrs by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503059 | Induction of apoptosis in human HL60 cells 1 uM incubated for 24 hrs by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503031 | Cytotoxicity in human HepG2 cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503060 | Induction of apoptosis in human HL60 cells 3 uM incubated for 24 hrs by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503042 | Cytotoxicity in HEK293T cells transfected with pIRESneo construct assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503043 | Cytotoxicity in human HeLa cells transfected with non targetting vector assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503054 | Cytotoxicity in human HL60 cells assessed as cell viability at 1 to 5 uM incubated for 48 hrs after 24 hrs pre-treatment with 50 uM BSO before compound addition by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503025 | Effect on TrxR1 protein expression in human HL60 cells at 1 to 5 uM incubated for 24 hrs by Western blot | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID363329 | Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
| Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. |
| AID1503058 | Induction of apoptosis in human HL60 cells 0.5 uM incubated for 24 hrs by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503027 | Cytotoxicity in human HL60 cells assessed as cell viability at 20 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503037 | Irreversible inhibition of NADPH-reduced rat TrxR1 assessed as suppression of DTNB reduction incubated for 1 hr followed by compound removal from incubation mixture by column desalting | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503063 | Induction of necrosis in human HL60 cells 5 uM incubated for 24 hrs by Annexin V/propidium iodide staining based flow cytometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503056 | Induction of apoptosis in human HL60 cells assessed as increase in caspase-3 activity at 5 uM incubated for 24 hrs using Ac-DEVD-pNA substrate by colorimetric assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503055 | Induction of apoptosis in human HL60 cells assessed as increase in caspase-3 activity at 1 to 3 uM incubated for 24 hrs using Ac-DEVD-pNA substrate by colorimetric assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503044 | Cytotoxicity in human HeLa cells transfected with shTrxR1 assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503057 | Induction of apoptosis in human HL60 cells assessed as increase in condensed and fluorescent nuclei at 1 to 5 uM incubated for 24 hrs by Hoechst 33342 staining based phase contrast and fluorescence microscopy | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503033 | Cytotoxicity in human HeLa cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID189750 | Anticancer activity against Walker 256 carcinoma in rat after administration of 10 mg/kg; Activity expressed as % T/C (Active) | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID189750 | Anticancer activity against Walker 256 carcinoma in rat after administration of 10 mg/kg; Activity expressed as % T/C (Active) | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID363328 | Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay | 2008 | European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
| Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. |
| AID1503050 | Potentiation of H2O2-induced cytotoxicity in human HL60 cells assessed as induction of cell death at 1 uM incubated for 24 hrs by MTT assay (Rvb = 4%) | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503038 | Inhibition of NADPH-reduced rat TrxR1 U498C mutant assessed as suppression of DTNB reduction at 1 to 5 uM incubated for 1 hr | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503036 | Inhibition of NADPH-reduced rat TrxR1 assessed as suppression of DTNB reduction incubated for 1 hr | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503047 | Reduction in intracellular thiols in human HL60 cells at 1 to 5 uM incubated for 24 hrs by DTNB titration method | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503053 | Cytotoxicity in human HL60 cells assessed as cell viability at 1 to 5 uM incubated for 24 hrs after pre-treatment with 0.5 to 5 uM NAC before compound addition by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503049 | Cytotoxicity in human HL60 cells assessed as induction of cell death at 1 uM incubated for 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503035 | Cytotoxicity in human L02 cells assessed as reduction in cell viability at 1 to 5 uM incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503052 | Cytotoxicity in human HL60 cells assessed as cell viability at 1 to 5 uM incubated for 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503029 | Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503028 | Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503030 | Cytotoxicity in human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by trypan blue dye exclusion assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503041 | Inhibition of TrxR1 in human HL60 cells incubated for 24 hrs by endpoint insulin reduction assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID1503046 | Induction of ROS production in human HL60 cells at 1 to 5 uM incubated for 1 hr by DHE staining based fluorescence assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| AID192093 | Anticancer activity against Walker 256 carcinoma cells in rat after administration of 10 mg/kg; Activity expressed as survivors out of 4 rats (Active) | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
| Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents. |
| AID192093 | Anticancer activity against Walker 256 carcinoma cells in rat after administration of 10 mg/kg; Activity expressed as survivors out of 4 rats (Active) | 2004 | Bioorganic & medicinal chemistry letters, Jun-07, Volume: 14, Issue:11
| Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents. |
| AID1503051 | Potentiation of H2O2-induced cytotoxicity in human HL60 cells assessed as induction of cell death at 3 uM incubated for 24 hrs by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |