| Assay ID | Title | Year | Journal | Article |
|---|
| AID93392 | Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]kainate as radioligand | 2000 | Journal of medicinal chemistry, May-18, Volume: 43, Issue:10
| 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. |
| AID611783 | Agonist activity at non-desensitized homomeric rat GluK3 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID611782 | Agonist activity at rat GluK2 mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID339928 | Displacement of [3H]SYM2081 from rat recombinant iGluR6 | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. |
| AID339929 | Displacement of [3H]SYM2081 from rat recombinant iGluR7 | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. |
| AID257133 | Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assay | 2005 | Journal of medicinal chemistry, Dec-15, Volume: 48, Issue:25
| Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. |
| AID611792 | Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes at 1 mM by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID339927 | Displacement of [3H]SYM2081 from rat recombinant iGluR5 | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14
| Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7. |
| AID108985 | Ratio between EC50 of compound and glutamate measured against Metabotropic glutamate receptor 2 | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID439881 | Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx at 10 uM by luminescence reporter assay | 2010 | European journal of medicinal chemistry, Jan, Volume: 45, Issue:1
| Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. |
| AID229392 | Selectivity ratio of GluR6 to GluR5 | 2000 | Journal of medicinal chemistry, May-18, Volume: 43, Issue:10
| 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. |
| AID143458 | Ability to inhibit [3H]CGS-19,755 binding to AMPA receptors. | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
| Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors. |
| AID93552 | Ability to inhibit [3H]-KA binding to Ionotropic glutamate receptor kainate from rat cortical membranes. | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
| Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors. |
| AID92942 | Ability to inhibit [3H]AMPA binding to Ionotropic glutamate receptor AMPA | 1995 | Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
| Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors. |
| AID611791 | Agonist activity at Non-desensitized homomeric rat GluK1(Q)1b mutant expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID108506 | Ratio between EC50 of compound and glutamate measured against metabotropic glutamate receptor 1 | 1999 | Journal of medicinal chemistry, May-06, Volume: 42, Issue:9
| Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation. |
| AID257131 | Binding affinity to human EAAT1 expressed in HEK293 cells in FMP (FLPR) assay | 2005 | Journal of medicinal chemistry, Dec-15, Volume: 48, Issue:25
| Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. |
| AID257132 | Binding affinity to human EAAT2 expressed in HEK293 cells in FMP (FLPR) assay | 2005 | Journal of medicinal chemistry, Dec-15, Volume: 48, Issue:25
| Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3. |
| AID611795 | Agonist activity at non-desensitized homomeric rat GluK3 mutant expressed in Xenopus oocytes at 1 mM by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID93250 | Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]kainate as radioligand | 2000 | Journal of medicinal chemistry, May-18, Volume: 43, Issue:10
| 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. |
| AID611784 | Agonist activity at rat GluK2 mutant expressed in Xenopus oocytes at 1 mM by two-electrode voltage-clamp electrophysiology | 2011 | Journal of medicinal chemistry, Jul-14, Volume: 54, Issue:13
| Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |