Compounds > tyroscherin
Page last updated: 2024-11-12

tyroscherin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tyroscherin: an antineoplastic antibiotic; isolated from Pseudallescheria; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11371027
CHEMBL ID1684465
MeSH IDM0480157

Synonyms (3)

Synonym
CHEMBL1684465
tyroscherin1
tyroscherin
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID578938Antiproliferative activity against human MCF7 cells assessed as inhibition of 10 % FBS-driven mitogenesis after 4 hrs by [3H]-thymidine incorporation assay2011Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
Unexpected stereochemical tolerance for the biological activity of tyroscherin.
AID578937Antiproliferative activity against human MCF7 cells assessed as inhibition of 100 ng/ml IGF-driven mitogenesis after 4 hrs by [3H]-thymidine incorporation assay2011Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
Unexpected stereochemical tolerance for the biological activity of tyroscherin.
AID578936Antiproliferative activity against human MCF7 cells assessed as inhibition of 10 ng/ml IGF-driven mitogenesis after 4 hrs by [3H]-thymidine incorporation assay2011Bioorganic & medicinal chemistry, Mar-01, Volume: 19, Issue:5
Unexpected stereochemical tolerance for the biological activity of tyroscherin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
miconazole
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.		2.0810dichlorobenzene;
ether;
imidazoles
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0610
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0610