Page last updated: 2024-12-08
f 4
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
F 4: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 191273 |
| CHEMBL ID | 251721 |
| MeSH ID | M0047977 |
Synonyms (8)
| Synonym |
|---|
| 53347-38-9 |
| f 4 |
| CHEMBL251721 |
| 2-amino-4-(2-ethynyl-1-methyl-5-nitroimidazole)pyrimidine |
| f-4 |
| 2-pyrimidinamine, 4-((1-methyl-5-nitro-1h-imidazol-2-yl)ethynyl)- |
| DTXSID10201506 |
| 4-((1-methyl-5-nitro-1h-imidazol-2-yl)ethynyl)pyrimidin-2-amine |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " We previously described the synthesis of 1-O-octadecyl-2-O-benzyl-glycero-3-phospho-RVn (V2043), an orally bioavailable lipid prodrug of remdesivir nucleoside (RVn, GS-441524) with broad spectrum antiviral activity against viruses with pandemic potential." | ( Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs. Beadle, JR; Carlin, AF; Clark, AE; Freshman, JE; Garretson, AF; Hostetler, KY; Lo, MK; McMillan, RE; Montgomery, JM; Murphy, J; Schooley, RT; Spiropoulou, CF; Valiaeva, N; Zhang, XQ, 2023) | 0.91 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID309820 | Antifungal activity against Candida sp. | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| AID309817 | Antibacterial activity against staphylococcus aureus ATCC 25923 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| AID309818 | Antibacterial activity against Escherichia coli ATCC 25923 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| AID309819 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27753 | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| AID309816 | Antibacterial activity against Mycobacterium tuberculosis H37Rv by microdilution resazurin assay | 2007 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22 | New biologically active epidioxysterols from Stereum hirsutum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 128.57
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (128.57) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||