Page last updated: 2024-12-08

f 4

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

F 4: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID191273
CHEMBL ID251721
MeSH IDM0047977

Synonyms (8)

Synonym
53347-38-9
f 4
CHEMBL251721
2-amino-4-(2-ethynyl-1-methyl-5-nitroimidazole)pyrimidine
f-4
2-pyrimidinamine, 4-((1-methyl-5-nitro-1h-imidazol-2-yl)ethynyl)-
DTXSID10201506
4-((1-methyl-5-nitro-1h-imidazol-2-yl)ethynyl)pyrimidin-2-amine

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" We previously described the synthesis of 1-O-octadecyl-2-O-benzyl-glycero-3-phospho-RVn (V2043), an orally bioavailable lipid prodrug of remdesivir nucleoside (RVn, GS-441524) with broad spectrum antiviral activity against viruses with pandemic potential."( Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs.
Beadle, JR; Carlin, AF; Clark, AE; Freshman, JE; Garretson, AF; Hostetler, KY; Lo, MK; McMillan, RE; Montgomery, JM; Murphy, J; Schooley, RT; Spiropoulou, CF; Valiaeva, N; Zhang, XQ, 2023
)
0.91
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID309820Antifungal activity against Candida sp.2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
New biologically active epidioxysterols from Stereum hirsutum.
AID309817Antibacterial activity against staphylococcus aureus ATCC 259232007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
New biologically active epidioxysterols from Stereum hirsutum.
AID309818Antibacterial activity against Escherichia coli ATCC 259232007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
New biologically active epidioxysterols from Stereum hirsutum.
AID309819Antibacterial activity against Pseudomonas aeruginosa ATCC 277532007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
New biologically active epidioxysterols from Stereum hirsutum.
AID309816Antibacterial activity against Mycobacterium tuberculosis H37Rv by microdilution resazurin assay2007Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22
New biologically active epidioxysterols from Stereum hirsutum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's3 (60.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 128.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index128.57 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index229.61 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (128.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]