Compounds > 5,8-epidioxyergosta-6,9(11),22-trien-3-ol

Page last updated: 2024-11-11

5,8-epidioxyergosta-6,9(11),22-trien-3-ol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

5,8-epidioxyergosta-6,9(11),22-trien-3-ol: from Ganoderma lucidum; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	11112737
CHEMBL ID	449356
MeSH ID	M0197692

Synonyms (8)

Synonym
CHEMBL449356
5,8-epidioxyergosta-6,9(11),22-trien-3-ol
86363-50-0
(1s,2r,5r,6r,10r,13s,15s)-5-[(e,2r,5r)-5,6-dimethylhept-3-en-2-yl]-6,10-dimethyl-16,17-dioxapentacyclo[13.2.2.01,9.02,6.010,15]nonadeca-8,18-dien-13-ol
5a,8a-epidioxyergosta-6,9(11),22-trien-3
HY-N7175
CS-0103795
FS-8080

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID309819	Antibacterial activity against Pseudomonas aeruginosa ATCC 27753	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	New biologically active epidioxysterols from Stereum hirsutum.
AID744418	Cytotoxicity against human A549 cells	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID744420	Cytotoxicity against human MCF7 cells	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID1676606	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability <= 100 uM after 24 hrs by MTT assay
AID309816	Antibacterial activity against Mycobacterium tuberculosis H37Rv by microdilution resazurin assay	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	New biologically active epidioxysterols from Stereum hirsutum.
AID309818	Antibacterial activity against Escherichia coli ATCC 25923	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	New biologically active epidioxysterols from Stereum hirsutum.
AID744419	Cytotoxicity against human MDA-MB-231 cells	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID309820	Antifungal activity against Candida sp.	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	New biologically active epidioxysterols from Stereum hirsutum.
AID1676603	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 100 nM after 24 hrs in presence of ER antagonist ICI 182,780 by MTT assay
AID489306	Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 in stationary phase culture at pH 5.8 up to 200 ug/ml after 3 days followed by washout from day 4 to week 4 by microbroth dilution method	2010	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14	In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
AID489305	Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 2 weeks by microbroth dilution method	2010	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14	In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
AID744421	Cytotoxicity against human HepG2 cells	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
AID309817	Antibacterial activity against staphylococcus aureus ATCC 25923	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	New biologically active epidioxysterols from Stereum hirsutum.
AID744422	Cytotoxicity against human Hep3B cells	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Spirostanoids with 1,4-dien-3-one or 3β,7α-diol-5,6-ene moieties from Solanum violaceum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	2 (50.00)	24.3611
2020's	1 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.03	1	0	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
isoniazid Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).	2.05	1	0	carbohydrazide	antitubercular agent; drug allergen
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	2.03	1	0	dichlorobenzene; ether; imidazoles
ursolic acid [no description available]	2.05	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
beta-amyrin beta-amyrin: alpha-amyrin is also available; a 5 ring triterpene derived from oleanane that differs from alpha-amyrin in having the 29-carbon at the 20 position; RN given refers to (3 beta)-isomer. beta-amyrin : A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants.	2.05	1	0	pentacyclic triterpenoid; secondary alcohol	Aspergillus metabolite; plant metabolite
beta-amyrin acetate [no description available]	2.05	1	0	triterpenoid
3-acetyllupeol 3-acetyllupeol: from root of Euphorbia fischeriana Steud; RN refers to (3beta)-isomer	2.05	1	0	organic molecular entity	metabolite
diosgenin [no description available]	2.08	1	0	3beta-sterol; hexacyclic triterpenoid; sapogenin; spiroketal	antineoplastic agent; antiviral agent; apoptosis inducer; metabolite
3-hydroxystigmast-5-en-7-one [no description available]	2.08	1	0	steroid
f 4 F 4: structure	2.03	1	0
lupeol [no description available]	2.05	1	0	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
yamogenin [no description available]	2.08	1	0	triterpenoid
syringaresinol (+)-syringaresinol : The (7alpha,7'alpha,8alpha,8'alpha)-stereoisomer of syringaresinol.	2.08	1	0	syringaresinol	antineoplastic agent
scopoletin [no description available]	2.08	1	0	hydroxycoumarin	plant growth regulator; plant metabolite
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	2.05	1	0	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
ergosterol-5,8-peroxide ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.	2.75	3	0	3beta-sterol; ergostanoid; organic peroxide; phytosterols	antimycobacterial drug; antineoplastic agent; metabolite; trypanocidal drug
stigmasterol 3-o-beta-d-glucopyranoside stigmasterol 3-O-beta-D-glucopyranoside: an antioxidant from Monochoria vaginalis; structure in first source. stigmasterol 3-O-beta-D-glucoside : A steroid saponin that is (3beta,22E)-stigmasta-5,22-dien-3-ol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It is isolated from Symplocos lancifolia.	2.05	1	0	beta-D-glucoside; monosaccharide derivative; phytosterols; steroid saponin	metabolite
diosgenone diosgenone: RN given for (25R)-isomer; isolated from Solanum nudum; structure in first source	2.08	1	0