miconazole has been researched along with Disease Models, Animal in 32 studies
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4% clotrimazole (Pyroace W) was tested in a guinea pig model of tinea pedis using a 1% newly solution formulated preparation of miconazole (Dermalin-L) as a reference drug." | 7.70 | [Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis]. ( Uchida, K; Ymaguchi, H, 1999) |
| "Miconazole treatment increased oligodendrocyte maturation and myelin sheath thickness without reducing Aβ plaque deposition, reactive gliosis, and inflammatory factor levels in the mPFC." | 5.72 | Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease. ( Chen, S; Chen, Y; Ding, S; Feng, W; Marshall, C; Pang, Y; Sheng, C; Shi, J; Wang, Z; Xiao, M; Zhang, Y, 2022) |
| "Tioconazole is a new imidazole antifungal agent with broad-spectrum activity." | 5.27 | Tioconazole, a new imidazole-antifungal agent for the treatment of dermatomycoses. Antifungal and pharmacologic properties. ( Baird, JR; Brammer, KW; Faulkner, JK; Halliwell, G; Jevons, S; Marriott, MS; Tarbit, MH, 1983) |
| "4% clotrimazole (Pyroace W) was tested in a guinea pig model of tinea pedis using a 1% newly solution formulated preparation of miconazole (Dermalin-L) as a reference drug." | 3.70 | [Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis]. ( Uchida, K; Ymaguchi, H, 1999) |
| "The therapy of coccidioidomycosis has been an early target, both experimentally and clinically, for study of new members of the azole class of drugs, because of the recognition that coccidioidomycosis is one of the most difficult mycoses to treat, and because our research group and our collaborators have been eager to pioneer new therapies for this problem pathogen." | 2.44 | Azole therapy of clinical and experimental coccidioidomycosis. ( Clemons, KV; Stevens, DA, 2007) |
| "Miconazole treatment increased oligodendrocyte maturation and myelin sheath thickness without reducing Aβ plaque deposition, reactive gliosis, and inflammatory factor levels in the mPFC." | 1.72 | Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease. ( Chen, S; Chen, Y; Ding, S; Feng, W; Marshall, C; Pang, Y; Sheng, C; Shi, J; Wang, Z; Xiao, M; Zhang, Y, 2022) |
| "The extemporaneously prepared miconazole eye drops are effective and safe to use in keratomycosis." | 1.48 | Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis. ( Ababio-Danso, B; Asare, F; Gyanfosu, L; Koffuor, GA; Kyei, S; Nyansah, WB; Peprah-Donkor, K, 2018) |
| "Miconazole appears to enhance remyelination in the central nervous system." | 1.48 | Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury. ( Lin, T; Liu, X; Qiu, S; Yan, L; Zheng, C; Zhu, Q; Zhu, S, 2018) |
| "Tioconazole is a new imidazole antifungal agent with broad-spectrum activity." | 1.27 | Tioconazole, a new imidazole-antifungal agent for the treatment of dermatomycoses. Antifungal and pharmacologic properties. ( Baird, JR; Brammer, KW; Faulkner, JK; Halliwell, G; Jevons, S; Marriott, MS; Tarbit, MH, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (28.13) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 11 (34.38) | 24.3611 |
| 2020's | 6 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Bardiot, D | 1 |
| Thevissen, K | 1 |
| De Brucker, K | 1 |
| Peeters, A | 1 |
| Cos, P | 2 |
| Taborda, CP | 1 |
| McNaughton, M | 1 |
| Maes, L | 1 |
| Chaltin, P | 1 |
| Cammue, BP | 1 |
| Marchand, A | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 2 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Xu, H | 2 |
| Yan, ZZ | 1 |
| Guo, MB | 1 |
| An, R | 1 |
| Wang, X | 1 |
| Zhang, R | 1 |
| Mou, YH | 1 |
| Hou, Z | 1 |
| Guo, C | 1 |
| Wang, Z | 1 |
| Zhang, Y | 2 |
| Feng, W | 1 |
| Pang, Y | 1 |
| Chen, S | 1 |
| Ding, S | 1 |
| Chen, Y | 1 |
| Sheng, C | 1 |
| Marshall, C | 1 |
| Shi, J | 1 |
| Xiao, M | 1 |
| Zhang, L | 2 |
| Chen, X | 1 |
| Liu, Z | 2 |
| Han, Q | 1 |
| Tang, L | 1 |
| Tian, Z | 1 |
| Ren, Z | 1 |
| Rong, C | 1 |
| Yoon, SH | 1 |
| Kim, BK | 1 |
| Kang, MJ | 1 |
| Im, JY | 1 |
| Won, M | 1 |
| Yeo, IJ | 1 |
| Yun, J | 1 |
| Son, DJ | 1 |
| Han, SB | 1 |
| Hong, JT | 1 |
| Gyanfosu, L | 1 |
| Koffuor, GA | 1 |
| Kyei, S | 1 |
| Ababio-Danso, B | 1 |
| Peprah-Donkor, K | 1 |
| Nyansah, WB | 1 |
| Asare, F | 1 |
| Lin, T | 1 |
| Qiu, S | 1 |
| Yan, L | 1 |
| Zhu, S | 1 |
| Zheng, C | 1 |
| Zhu, Q | 1 |
| Liu, X | 1 |
| Fernandes Costa, A | 1 |
| Evangelista Araujo, D | 1 |
| Santos Cabral, M | 1 |
| Teles Brito, I | 1 |
| Borges de Menezes Leite, L | 1 |
| Pereira, M | 1 |
| Correa Amaral, A | 1 |
| Pakharukova, MY | 1 |
| Pakharukov, YV | 1 |
| Mordvinov, VA | 1 |
| Precazzini, F | 1 |
| Pancher, M | 1 |
| Gatto, P | 1 |
| Tushe, A | 1 |
| Adami, V | 1 |
| Anelli, V | 1 |
| Mione, MC | 1 |
| Bertacchi, M | 1 |
| Gruart, A | 1 |
| Kaimakis, P | 1 |
| Allet, C | 1 |
| Serra, L | 1 |
| Giacobini, P | 1 |
| Delgado-García, JM | 1 |
| Bovolenta, P | 1 |
| Studer, M | 1 |
| Najm, FJ | 1 |
| Madhavan, M | 1 |
| Zaremba, A | 1 |
| Shick, E | 1 |
| Karl, RT | 1 |
| Factor, DC | 1 |
| Miller, TE | 1 |
| Nevin, ZS | 1 |
| Kantor, C | 1 |
| Sargent, A | 1 |
| Quick, KL | 1 |
| Schlatzer, DM | 1 |
| Tang, H | 1 |
| Papoian, R | 1 |
| Brimacombe, KR | 1 |
| Shen, M | 1 |
| Boxer, MB | 1 |
| Robinson, AP | 1 |
| Podojil, JR | 1 |
| Miller, SD | 1 |
| Miller, RH | 1 |
| Tesar, PJ | 1 |
| Torikai, M | 1 |
| Ibara, S | 1 |
| Ieiri, S | 1 |
| Hamada, T | 1 |
| Noguchi, H | 1 |
| Sueyoshi, K | 1 |
| Fukuda, T | 1 |
| Abeyama, K | 1 |
| Yang, R | 1 |
| Huang, D | 1 |
| Luo, X | 1 |
| Zhu, X | 1 |
| Zhang, X | 1 |
| Han, JY | 1 |
| Xiong, JW | 1 |
| Van den Driessche, F | 1 |
| Vanhoutte, B | 1 |
| Brackman, G | 1 |
| Crabbé, A | 1 |
| Rigole, P | 1 |
| Vercruysse, J | 1 |
| Verstraete, G | 1 |
| Cappoen, D | 1 |
| Vervaet, C | 1 |
| Coenye, T | 1 |
| Stevens, DA | 1 |
| Clemons, KV | 1 |
| Jones, DB | 1 |
| Marriott, MS | 1 |
| Baird, JR | 1 |
| Brammer, KW | 1 |
| Faulkner, JK | 1 |
| Halliwell, G | 1 |
| Jevons, S | 1 |
| Tarbit, MH | 1 |
| Oji, EO | 2 |
| Clayton, YM | 1 |
| Parmegiani, RM | 1 |
| Loebenberg, D | 1 |
| Cacciapuoti, A | 1 |
| Antonacci, B | 1 |
| Norris, C | 1 |
| Menzel, F | 1 |
| Moss, L | 1 |
| Yarosh-Tomaine, T | 1 |
| Hare, RS | 1 |
| Miller, GH | 1 |
| Asikoglu, M | 1 |
| Ertan, G | 1 |
| Ercan, MT | 1 |
| Duman, Y | 1 |
| Uchida, K | 1 |
| Ymaguchi, H | 1 |
| McRipley, RJ | 1 |
| Erhard, PJ | 1 |
| Schwind, RA | 1 |
| Whitney, RR | 1 |
| Levine, HB | 1 |
| Anaissie, E | 1 |
| Gokaslan, A | 1 |
| Hachem, R | 1 |
| Rubin, R | 1 |
| Griffin, G | 1 |
| Robinson, R | 1 |
| Sobel, J | 1 |
| Bodey, G | 1 |
| Georgiev, VS | 1 |
| Ackerbauer, H | 1 |
| Meingassner, JG | 1 |
| Mieth, H | 1 |
| Smith, KJ | 1 |
| Warnock, DW | 1 |
| Kennedy, CT | 1 |
| Johnson, EM | 1 |
| Hopwood, V | 1 |
| Van Cutsem, J | 1 |
| Vanden Bossche, H | 1 |
| Ahmad, S | 1 |
| Boone, D | 1 |
| Hall, D | 1 |
| Cole, JJ | 1 |
| Dennis, MB | 1 |
2 reviews available for miconazole and Disease Models, Animal
| Article | Year |
|---|---|
Azole therapy of clinical and experimental coccidioidomycosis.
Topics: Administration, Oral; Animals; Antifungal Agents; Azoles; Coccidioidomycosis; Disease Models, Animal | 2007 |
Treatment and developmental therapeutics in aspergillosis. 2. Azoles and other antifungal drugs.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Azoles; Clotrim | 1992 |
30 other studies available for miconazole and Disease Models, Animal
| Article | Year |
|---|---|
2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents.
Topics: Acetamides; Animals; Antifungal Agents; Candida; Candidiasis; Disease Models, Animal; Dose-Response | 2015 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections.
Topics: 14-alpha Demethylase Inhibitors; Animals; Antifungal Agents; Binding Sites; Biofilms; Candida; Candi | 2021 |
Miconazole Promotes Cooperative Ability of a Mouse Model of Alzheimer Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2022 |
Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF-κB pathway.
Topics: Animals; Crush Injuries; Cytochrome P-450 CYP2C9 Inhibitors; Disease Models, Animal; Macrophages; Ma | 2019 |
Miconazole inhibits signal transducer and activator of transcription 3 signaling by preventing its interaction with DNA damage-induced apoptosis suppressor.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Damage; Drug S | 2020 |
Antifungal drug miconazole ameliorated memory deficits in a mouse model of LPS-induced memory loss through targeting iNOS.
Topics: Animals; Antifungal Agents; Astrocytes; Brain; Cell Nucleus; Cells, Cultured; Cytokines; Disease Mod | 2020 |
Efficacy and safety of extemporaneously prepared miconazole eye drops in Candida albicans-induced keratomycosis.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis; Cornea; Disease Models, Animal; Eye Infec | 2018 |
Miconazole enhances nerve regeneration and functional recovery after sciatic nerve crush injury.
Topics: 14-alpha Demethylase Inhibitors; Action Potentials; Animals; Cell Count; Cell Line, Transformed; Cel | 2018 |
Development, characterization, and in vitro-in vivo evaluation of polymeric nanoparticles containing miconazole and farnesol for treatment of vulvovaginal candidiasis.
Topics: Animals; Antifungal Agents; BALB 3T3 Cells; Candida albicans; Candidiasis, Vulvovaginal; Capsules; C | 2019 |
Effects of miconazole/clotrimazole and praziquantel combinations against the liver fluke Opisthorchis felineus in vivo and in vitro.
Topics: Animals; Anthelmintics; Clotrimazole; Cricetinae; Disease Models, Animal; Drug Therapy, Combination; | 2018 |
Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 2020 |
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome.
Topics: Animals; Astrocytes; Behavior, Animal; COUP Transcription Factor I; Disease Models, Animal; Genetic | 2019 |
Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo.
Topics: Animals; Cell Differentiation; Cerebellum; Clobetasol; Demyelinating Diseases; Disease Models, Anima | 2015 |
Prophylactic efficacy of enteral miconazole administration for neonatal intestinal perforation and its potential mechanism.
Topics: Animals; Caco-2 Cells; Cytochrome P-450 CYP2C9 Inhibitors; Disease Models, Animal; Humans; Intestina | 2016 |
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Topics: Animals; Blood Vessels; Cerebral Hemorrhage; Disease Models, Animal; Drug Evaluation, Preclinical; E | 2017 |
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models.
Topics: A549 Cells; Animals; Biofilms; Burkholderia cenocepacia; Burkholderia Infections; Disease Models, An | 2017 |
Chemotherapy of experimental endogenous Candida albicans endophthalmitis.
Topics: Amphotericin B; Animals; Antifungal Agents; Candidiasis; Disease Models, Animal; Drug Therapy, Combi | 1980 |
Tioconazole, a new imidazole-antifungal agent for the treatment of dermatomycoses. Antifungal and pharmacologic properties.
Topics: Animals; Antifungal Agents; Chemical Phenomena; Chemistry; Dermatomycoses; Disease Models, Animal; G | 1983 |
Development of quantitative methods of measuring antifungal drug effects in the rabbit cornea.
Topics: Animals; Candidiasis; Clotrimazole; Cornea; Corneal Diseases; Disease Models, Animal; Miconazole; Mi | 1981 |
The role of econazole in the management of oculomycosis.
Topics: Animals; Candidiasis; Clotrimazole; Corneal Diseases; Disease Models, Animal; Econazole; Fungi; Imid | 1982 |
Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections.
Topics: Administration, Oral; Administration, Topical; Animals; Antifungal Agents; Candidiasis, Vulvovaginal | 1993 |
The release of isoconazole nitrate from different suppository bases: in-vivo release of drug labelled with 99mTc in rabbits.
Topics: Animals; Antifungal Agents; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Syste | 1995 |
[Therapeutic efficacy of a topical antifungal solution preparation formulated with pyrrolnitrin and clotrimazole in combination (Pyroace W) in guinea pig model of tinea pedis].
Topics: Animals; Antifungal Agents; Clotrimazole; Disease Models, Animal; Drug Combinations; Guinea Pigs; Ma | 1999 |
Evaluation of vaginal antifungal formulations in vivo.
Topics: Animals; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Clotrimazole; Disease Model | 1979 |
R34000, a dioxolane imidazole in the therapy for experimental coccidioidomycosis. Comparison with miconazole and econazole.
Topics: Administration, Oral; Animals; Coccidioides; Coccidioidomycosis; Dioxolanes; Dioxoles; Disease Model | 1976 |
Azole therapy for trichosporonosis: clinical evaluation of eight patients, experimental therapy for murine infection, and review.
Topics: Adult; Aged; Amphotericin B; Animals; Antifungal Agents; Child, Preschool; Disease Models, Animal; F | 1992 |
[Experimental renal infection with Aspergillus fumigatus in mice: a chemotherapeutic model of an organic mycosis].
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, An | 1985 |
Azole resistance in Candida albicans.
Topics: Adult; Animals; Antifungal Agents; Candida albicans; Candidiasis; Candidiasis, Chronic Mucocutaneous | 1986 |
An animal model for fungal peritonitis: evaluation of therapeutic options.
Topics: Administration, Oral; Animals; Candidiasis; Catheters, Indwelling; Disease Models, Animal; Drug Eval | 1986 |