linoleic-acid and Disseminated-Intravascular-Coagulation

linoleic-acid has been researched along with Disseminated-Intravascular-Coagulation* in 2 studies

Other Studies

2 other study(ies) available for linoleic-acid and Disseminated-Intravascular-Coagulation

Article	Year
Sodium oleate, arachidonate, and linoleate enhance fibrinogenolysis by Russell's viper venom proteinases and inhibit FXIIIa; a role for phospholipase A Toxicon : official journal of the International Society on Toxinology, 2020, Oct-30, Volume: 186 Life-threatening symptoms produced by Russell's viper (RV, Daboia russelii) envenomation result largely from venom induced consumption coagulopathy (VICC). VICC is thought to be mediated to a large degree by venom serine and metalloproteinases, as well as by snake venom phospholipase A Topics: Animals; Antivenins; Arachidonic Acid; Blood Coagulation Disorders; Daboia; Disseminated Intravascular Coagulation; Endopeptidases; Factor XIIIa; Linoleic Acid; Metalloproteases; Oleic Acid; Peptide Hydrolases; Phospholipases A2; Viper Venoms	2020
The role of leukotoxin (9,10-epoxy-12-octadecenoate) in the genesis of coagulation abnormalities. Life sciences, 1988, Volume: 43, Issue:3 This study was designed to clarify whether or not leukotoxin (9, 10-epoxy-12-octadecenoate), which is biosynthesized by neutrophils, might be involved in the genesis of coagulating abnormalities. Twelve dogs were divided into 2 groups. In the test group (n = 6), 100 mumol/kg of leukotoxin was injected intravenously, and in the control group (n = 6), 100 mumol/kg of linoleate was injected. In each group, a series of blood samples were collected and used for coagulation studies. After the end of the experimental period, a histological study was performed on organs removed from the dogs. In the leukotoxin group, fibrin and fibrinogen degradation products (FDP) was increased time-dependently. Fibrinogen was decreased, and prothrombin time and activated partial thromboplastin time were prolonged in parallel with the increase in FDP. A decrease in number of platelets was also observed. Intravascular coagulation was observed in sections of lung. These data were compatible with a diagnosis of disseminated intravascular coagulation (DIC). No significant changes in these parameters were observed in the linoleate group. Leukotoxin has been confirmed to show antifungal and antibacterial activity, and its production might be a defensive response to infection. Over-production of leukotoxin associated with severe infection might therefore account for infection-induced DIC. Topics: Animals; Disseminated Intravascular Coagulation; Dogs; Female; Fibrin Fibrinogen Degradation Products; Linoleic Acid; Linoleic Acids; Lung; Male; Partial Thromboplastin Time; Platelet Count; Prothrombin Time; Toxins, Biological	1988

Article

Year

Sodium oleate, arachidonate, and linoleate enhance fibrinogenolysis by Russell's viper venom proteinases and inhibit FXIIIa; a role for phospholipase A

Toxicon : official journal of the International Society on Toxinology, 2020, Oct-30, Volume: 186

Life-threatening symptoms produced by Russell's viper (RV, Daboia russelii) envenomation result largely from venom induced consumption coagulopathy (VICC). VICC is thought to be mediated to a large degree by venom serine and metalloproteinases, as well as by snake venom phospholipase A

Topics: Animals; Antivenins; Arachidonic Acid; Blood Coagulation Disorders; Daboia; Disseminated Intravascular Coagulation; Endopeptidases; Factor XIIIa; Linoleic Acid; Metalloproteases; Oleic Acid; Peptide Hydrolases; Phospholipases A2; Viper Venoms

2020

The role of leukotoxin (9,10-epoxy-12-octadecenoate) in the genesis of coagulation abnormalities.

Life sciences, 1988, Volume: 43, Issue:3

This study was designed to clarify whether or not leukotoxin (9, 10-epoxy-12-octadecenoate), which is biosynthesized by neutrophils, might be involved in the genesis of coagulating abnormalities. Twelve dogs were divided into 2 groups. In the test group (n = 6), 100 mumol/kg of leukotoxin was injected intravenously, and in the control group (n = 6), 100 mumol/kg of linoleate was injected. In each group, a series of blood samples were collected and used for coagulation studies. After the end of the experimental period, a histological study was performed on organs removed from the dogs. In the leukotoxin group, fibrin and fibrinogen degradation products (FDP) was increased time-dependently. Fibrinogen was decreased, and prothrombin time and activated partial thromboplastin time were prolonged in parallel with the increase in FDP. A decrease in number of platelets was also observed. Intravascular coagulation was observed in sections of lung. These data were compatible with a diagnosis of disseminated intravascular coagulation (DIC). No significant changes in these parameters were observed in the linoleate group. Leukotoxin has been confirmed to show antifungal and antibacterial activity, and its production might be a defensive response to infection. Over-production of leukotoxin associated with severe infection might therefore account for infection-induced DIC.

Topics: Animals; Disseminated Intravascular Coagulation; Dogs; Female; Fibrin Fibrinogen Degradation Products; Linoleic Acid; Linoleic Acids; Lung; Male; Partial Thromboplastin Time; Platelet Count; Prothrombin Time; Toxins, Biological

1988