linoleic-acid and Muscular-Dystrophy--Animal

linoleic-acid has been researched along with Muscular-Dystrophy--Animal* in 2 studies

Other Studies

2 other study(ies) available for linoleic-acid and Muscular-Dystrophy--Animal

ArticleYear
The biological activity of natural source tocopherols in chickens fed fresh or oxidized fat rich in linoleic acid.
    Archiv fur Tierernahrung, 1993, Volume: 44, Issue:4

    Three experiments were carried out with male broiler chickens reared from day- old to 6 weeks of age on semi-purified diets containing 10% fresh (Expt. 1 and 3) or oxidized (Expt. 2) re-esterified triglycerides with a fatty acid composition similar to that of soya bean oil containing increasing concentrations of either a mixture of d-alpha-, gamma-, delta-tocopherylacetate (d-tocopherols) of natural source or dl-alpha- tocopheryl acetate (dl-tocopherol). In Expt. 1 and 2 the mixture of d-tocopherols consisted of 35.7% d-alpha-, 45.3% d-gamma- and 19.0% d-delta-, while in Expt. 3 the distribution was 25.3% d-alpha-, 28.1% d-gamma- and 10.8% d-gamma- in 35.8% re-esterified triglycerides. The relative biopotency of d-alpha-: gamma-: delta-tocopherol was anticipated to be 100:25:1, whereas that of dl-alpha-tocopherol was 74% relative to d-alpha-tocopherol. The experiments demonstrate that the results obtained for the biological activity depend on the response parameters chosen. With respect to gain in weight, feed conversion, relative organ weight, packed cell volume (PCV), ELP (erythrocyte lipid peroxidation), plasma activities of glutamate-oxaloacetate-transaminase (GOT), creatine kinase (CK) and glutathione peroxidase (GSH-Px) and plasma Na+ concentration, the mixture of natural source tocopherols was identical to that of dl-alpha-tocopheryl acetate, although the concentration of alpha-tocopherol was only about one third of that of dl-alpha-tocopherol. Differences between natural source and synthetic tocopherols were expectedly observed with respect to plasma concentrations of alpha-, gamma-, delta-tocopherol. Differences between the two forms as to muscular dystrophy, in vitro haemolysis and potassium concentration in plasma were ambiguous. It is suggested that the function of d-alpha-, gamma-, delta-tocopherol in erythrocyte fragility and skeletal muscle structure should be compared to that of dl-alpha-tocopherol in future investigations.

    Topics: Animals; Aspartate Aminotransferases; Cerebellar Diseases; Cerebral Hemorrhage; Chickens; Creatine Kinase; Dietary Fats; Eating; Encephalomalacia; Glutathione Peroxidase; Hematocrit; Linoleic Acid; Linoleic Acids; Liver; Male; Muscular Dystrophy, Animal; Organ Size; Oxidation-Reduction; Poultry Diseases; Vitamin E; Weight Gain

1993
Lipid fluidity and composition of the erythrocyte membrane from healthy dogs and Labrador retrievers with hereditary muscular dystrophy.
    Neurochemical research, 1991, Volume: 16, Issue:2

    Erythrocyte membranes and their liposomes were prepared from clinically normal dogs and Labrador retrievers with hereditary muscular dystrophy. The "static" and "dynamic" components of fluidity of each membrane were then assessed by steady-state fluorescence polarization techniques using limiting hindered fluorescence anisotropy and order parameter values of 1,6-diphenyl-1,3,5-hexatriene (DPH) and fluorescence anisotropy values of DL-2-(9-anthroyl)-stearic acid and DL-12-(9-anthroyl)-stearic acid, respectively. Membrane lipids were extracted and analyzed by thin-layer chromatography and gas chromatography. The results of these studies demonstrated that the lipid fluidity of erythrocyte membranes, and their liposomes, prepared from dystrophic dogs were found to possess significantly lower "static and dynamic components of fluidity" than control counterparts. Analysis of the composition of membranes from dystrophic dogs revealed a higher ratio of saturated fatty acyl chain/unsaturated chains (w/w) and lower double-bond index. Alterations in the fatty acid composition such as decrease in levels of linoleic (18:2) and arachidonic (20:4) acids and increase in palmitic (16:0) and stearic (18:0) acids were also observed in the membranes of dystrophic animals. These associated fatty acyl alterations could explain, at least in part, the differences in membrane fluidity between dystrophic and control dogs.

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Diphenylhexatriene; Dogs; Erythrocyte Membrane; Fluorescence Polarization; Fluorescent Dyes; Linoleic Acid; Linoleic Acids; Membrane Fluidity; Membrane Lipids; Muscular Dystrophy, Animal; Palmitic Acid; Palmitic Acids; Stearic Acids

1991