Page last updated: 2024-09-28

Metabolic Skin Diseases

Diseases of the skin associated with underlying metabolic disorders.

Synonyms(2)

Synonym
Skin Diseases, Metabolic
Metabolic Skin Diseases

Research

Studies (24)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's4 (16.67)12.5806
2000's8 (33.33)18.1394
2010's11 (45.83)28.8240
2020's1 (4.17)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
methylmalonic acid0low10
glyoxylic acid0low10
niacin0low10
propionic acid0low10
thiosulfates0low30
uric acid0low10
khellin0low10
valine0low10
isoleucine0low10
calcium gluconate0low10
zinc sulfate0low10
sodium thiosulfate0low20
calcium oxalate0low10
diltiazem0low20
retinol0low10
keratan sulfate0low10
linoleic acid0low10
vitamin d 20low10
alpha-linolenic acid0low10
paricalcitol0low10
oxalates0low10
heme0low10
minocycline0low10
allopurinol0low10

Protein Targets (337)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
interleukin 82002
TDP1 protein7007
AR protein6006
thyroid stimulating hormone receptor4004
estrogen receptor 2 (ER beta)6006
progesterone receptor4004
glucocorticoid receptor [Homo sapiens]7007
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha120012
IDH11001
euchromatic histone-lysine N-methyltransferase 25005
Bloom syndrome protein isoform 12002
transcriptional regulator ERG isoform 31001
thyroid hormone receptor beta isoform 27007
ras-related protein Rab-9A1001
nuclear factor erythroid 2-related factor 2 isoform 14004
geminin7007
survival motor neuron protein isoform d3003
lamin isoform A-delta104004
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40303
Polyphenol oxidase 20304
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump0404
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p538008
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0303
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0315
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 431001
Canalicular multispecific organic anion transporter 10303
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase3003
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain2002
Luciferase3003
thioredoxin reductase4004
15-lipoxygenase, partial3003
WRN1001
phosphopantetheinyl transferase2002
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma6006
SMAD family member 23003
USP1 protein, partial4004
GLS protein3003
SMAD family member 33003
GLI family zinc finger 37007
Microtubule-associated protein tau2002
thioredoxin glutathione reductase2002
aldehyde dehydrogenase 1 family, member A16006
regulator of G-protein signaling 42002
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor2002
pregnane X nuclear receptor4004
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma4004
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Caspase-71001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
phospholipase A2 precursor0101
vitamin D3 receptor isoform VDRA3003
caspase-31001
heat shock protein beta-13003
importin subunit beta-1 isoform 13003
serine/threonine-protein kinase PLK11001
snurportin-13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)2002
cysteine protease ATG4B isoform a0101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 12002
cytochrome P450 3A4 isoform 15005
histone acetyltransferase KAT2A isoform 15005
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Gamma-aminobutyric acid receptor subunit pi5005
Free fatty acid receptor 10022
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Prostaglandin G/H synthase 1 0202
Nuclear receptor subfamily 1 group I member 20011
Trypsin0202
Coagulation factor VII0202
Aromatase0202
Tissue factor0202
Gamma-aminobutyric acid receptor subunit beta-15005
Gamma-aminobutyric acid receptor subunit delta5005
Gamma-aminobutyric acid receptor subunit gamma-25005
Gamma-aminobutyric acid receptor subunit alpha-55005
Gamma-aminobutyric acid receptor subunit alpha-35005
Prostaglandin G/H synthase 10303
Gamma-aminobutyric acid receptor subunit gamma-15005
Gamma-aminobutyric acid receptor subunit alpha-25005
Gamma-aminobutyric acid receptor subunit alpha-45005
Gamma-aminobutyric acid receptor subunit gamma-35005
Gamma-aminobutyric acid receptor subunit alpha-65005
Peroxisome proliferator-activated receptor gamma0011
Histamine H2 receptor2002
Gamma-aminobutyric acid receptor subunit alpha-15005
Gamma-aminobutyric acid receptor subunit beta-35005
Gamma-aminobutyric acid receptor subunit beta-25005
Prostaglandin G/H synthase 20202
Free fatty acid receptor 40022
GABA theta subunit5005
Gamma-aminobutyric acid receptor subunit epsilon5005
ATP-dependent phosphofructokinase2002
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, JmjC domain-containing histone demethylation protein 3A4004
apical membrane antigen 1, AMA11001
nonstructural protein 10101
green fluorescent protein, partial0101
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
Histone H2A.x2002
acetylcholinesterase4004
nuclear receptor subfamily 1, group I, member 33003
cytochrome P450 family 3 subfamily A polypeptide 43003
aryl hydrocarbon receptor2002
thyroid stimulating hormone receptor2002
B2 bradykinin receptor0101
Dihydrofolate reductase0001
Dihydrofolate reductase0101
Chymotrypsinogen A0001
Beta-lactamase0101
Amyloid-beta precursor protein0404
Beta-lactamase0001
5-hydroxytryptamine receptor 2A0001
Beta-galactosidase0102
5-hydroxytryptamine receptor 1A0101
Choline O-acetyltransferase0101
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
PH domain leucine-rich repeat-containing protein phosphatase 20101
Chymotrypsin-C0101
cytochrome P450 2D62002
glucocerebrosidase1001
D(1A) dopamine receptor1001
huntingtin isoform 21001
Solute carrier family 22 member 1 0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40304
Cytochrome P450 2C9 0415
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1D0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20202
Spike glycoprotein1001
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Potassium voltage-gated channel subfamily A member 10101
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
4-hydroxy-tetrahydrodipicolinate synthase0101
Large neutral amino acids transporter small subunit 10202
Proton-coupled amino acid transporter 10101
glp-1 receptor, partial2002
GALC protein1001
G1001
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
mitogen-activated protein kinase 12002
GTP-binding nuclear protein Ran isoform 12002
peripheral myelin protein 222002
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 2D60101
Cytochrome P450 2C190101
Cytochrome P450 1B10101
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Sterol O-acyltransferase 10101
Fatty acid-binding protein, heart0202
Seed linoleate 13S-lipoxygenase-10101
Fatty acid-binding protein, adipocyte0202
Adenosine receptor A10101
Tyrosine-protein phosphatase non-receptor type 70101
Sterol O-acyltransferase 10101
Aldo-keto reductase family 1 member C30101
Nuclear receptor subfamily 4 group A member 20011
Dual specificity protein phosphatase 30101
Fatty acid-binding protein 50101
Peroxisome proliferator-activated receptor alpha1001
tumor susceptibility gene 101 protein1001
Guanine nucleotide-binding protein G1001
Serine racemase0101
EWS/FLI fusion protein1001
Albumin0112
Stromelysin-10112
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
bromodomain adjacent to zinc finger domain 2B1001
thyrotropin-releasing hormone receptor1001
lysosomal alpha-glucosidase preproprotein1001
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
Multidrug and toxin extrusion protein 10101
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Glucose-6-phosphate 1-dehydrogenase0101
Free fatty acid receptor 30011
Free fatty acid receptor 20112
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Free fatty acid receptor 20011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
pregnane X receptor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear receptor ROR-gamma isoform 11001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Alpha-synuclein0101
Nuclear receptor ROR-gamma1001
Disintegrin and metalloproteinase domain-containing protein 171001
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Polymerase acidic protein0011
Carbonic anhydrase 30101
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80202
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Chain A, Arginase 10101
eyes absent homolog 2 isoform a1001
Rap guanine nucleotide exchange factor 31001
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Vitamin D3 receptor0001
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]