12,13-epoxy-9-octadecenoic acid

Description

12,13-epoxy-9-octadecenoic acid, also known as **vernolic acid**, is a **fatty acid** with a **unique structure** containing an epoxy group (a three-membered ring with an oxygen atom) and a double bond.

**Importance for research:**

* **Anti-inflammatory properties:** Vernolic acid has shown **anti-inflammatory activity**, potentially acting through the inhibition of cyclooxygenase (COX) enzymes, key players in inflammation. This makes it an interesting target for the development of novel anti-inflammatory drugs.
* **Antioxidant activity:** Vernolic acid has demonstrated **antioxidant activity**, protecting cells from damage caused by free radicals. This property might be beneficial in the prevention and treatment of oxidative stress-related diseases.
* **Anti-cancer activity:** Several studies have shown that vernolic acid exhibits **anti-cancer activity**, inhibiting the growth of various cancer cells. This effect is attributed to its ability to induce apoptosis (programmed cell death) and inhibit angiogenesis (formation of new blood vessels).
* **Effect on lipid metabolism:** Vernolic acid has been shown to **modify lipid metabolism**, potentially influencing levels of cholesterol and other lipids in the body. This makes it relevant for the study of cardiovascular diseases and other conditions related to lipid imbalances.
* **Biofuel potential:** The epoxy group in vernolic acid makes it a potential candidate for the production of **biodiesel**, a renewable alternative to fossil fuels.
* **Industrial applications:** Vernolic acid is used in the **production of paints, plastics, and other industrial products**.

**Research perspectives:**

Further research on vernolic acid is necessary to fully understand its mechanisms of action and potential therapeutic applications. This includes:

* Identifying its exact targets in cells and tissues.
* Determining its bioavailability and pharmacokinetic properties.
* Conducting clinical trials to assess its safety and efficacy in humans.

Overall, 12,13-epoxy-9-octadecenoic acid (vernolic acid) is a promising molecule with a range of biological activities and potential applications in medicine, industry, and biofuel production.

12,13-epoxy-9-octadecenoic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]