Page last updated: 2024-11-12
fr236924
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
FR236924: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9904718 |
| CHEMBL ID | 8690 |
| SCHEMBL ID | 321064 |
| MeSH ID | M0454849 |
Synonyms (21)
| Synonym |
|---|
| 8-[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]octanoic acid |
| CHEMBL8690 |
| fr-236924 |
| dcp-la |
| 28399-31-7 |
| fr 236924 |
| 2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid |
| SCHEMBL321064 |
| CONYTTFKIUJZOF-UHFFFAOYSA-N |
| 8-(2-((2-pentylcyclopropan-1-yl)methyl)cyclopropyl)octanoic acid |
| AKOS024457420 |
| DTXSID10432656 |
| J-017057 |
| CS-0029279 |
| 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoic acid |
| HY-108599 |
| fr236924 |
| NCGC00387080-02 |
| F82161 |
| MS-24478 |
| 8-(2-((2-pentylcyclopropyl)methyl)cyclopropyl)octanoicacid |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| "The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs." | ( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019) | 0.51 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| "The newly synthesized linoleic acid derivative, FR236924, induces a long-lasting facilitation of hippocampal neurotransmission based on a persistent enhancement in the activity of presynaptic nicotinic ACh receptors via a PKC pathway and the ensuing increase in glutamate release, not only in vitro but in vivo at a low dosage (2mg/kg, ip), which suggested the possibility of its use as a promising anti-dementia drug." | ( The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Nishizaki, T; Tanaka, A, 2003) | 0.83 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID173772 | Intraperitoneal dose required to facilitate the hippocampal neurotransmission in rat | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. |
| AID145834 | Effect on Torpedo nicotinic ACh receptor responses at 0 min determined by measuring percentage of original amplitude | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. |
| AID145835 | Effect on Torpedo nicotinic ACh receptor responses at 10 min determined by measuring percentage of original amplitude | 2003 | Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6 | The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.87
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.87) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||