| Assay ID | Title | Year | Journal | Article |
|---|
| AID1149521 | Antitumor activity against mouse early Lewis lung carcinoma allografted in ip dosed BDF1 mouse assessed as disease cure administered as single dose on 1 or 2 days post-tumor implantation measured for 80 days post-drug treatment | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149482 | Antitumor activity against mouse early Lewis lung carcinoma allografted in BDF1 mouse assessed as increase in host life span at 13 mg/kg, ip administered as single dose on 1 or 2 days post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1133741 | Octanol-water partition coefficient, log P of the compound at pH 7.4 | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. |
| AID1133738 | Antitumor activity against mouse L1210 cells allografted in ip dosed BDF1 mouse assessed as increase of life span of host measured up to 45 days | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. |
| AID1149401 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in BDF1 mouse assessed as increase in host life span at 20 mg/kg, ip administered as single dose on 7th day post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID125581 | Tested for 3 log kill of leukemia cells | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia. |
| AID23276 | Partition coefficient (logP) | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia. |
| AID134226 | Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, activity is expressed as LD10 | 1980 | Journal of medicinal chemistry, Oct, Volume: 23, Issue:10
| Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia. |
| AID1149441 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in BDF1 mouse assessed as disease cure at 30 mg/kg, ip administered as single dose on 7th day post-tumor implantation measured for 80 days post-drug treatment | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149525 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in ip dosed BDF1 mouse assessed as complete regression of established tumor administered as single dose on day 6 or 7 post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149454 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in BDF1 mouse assessed as disease cure at 20 mg/kg, ip administered as single dose on 7th day post-tumor implantation measured for 80 days post-drug treatment | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149526 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in ip dosed BDF1 mouse assessed as disease cure administered as single dose on day 6 or 7 post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149388 | Antitumor activity against mouse advanced Lewis lung carcinoma allografted in BDF1 mouse assessed as increase in host life span at 30 mg/kg, ip administered as single dose on 7th day post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1133739 | Therapeutic index, ratio of LD10 for BDF1 mouse to ED50 for mouse L1210 cells allografted in ip dosed BDF1 mouse | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. |
| AID1149510 | Antitumor activity against mouse early Lewis lung carcinoma allografted in BDF1 mouse assessed as time delay in tumor growth at 13 mg/kg, ip administered as single dose on 1 or 2 days post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149523 | Ratio of ED50 for antitumor activity against mouse L1210 cells allografted in ip dosed mouse to LD10 for mouse | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149481 | Antitumor activity against mouse early Lewis lung carcinoma allografted in BDF1 mouse assessed as increase in host life span at 20 mg/kg, ip administered as single dose on 1 or 2 days post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1133737 | Toxicity in ip dosed BDF1 mouse | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Synthesis of analogues of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents. |
| AID1149511 | Antitumor activity against mouse early Lewis lung carcinoma allografted in BDF1 mouse assessed as time delay in tumor growth at 30 mg/kg, ip administered as single dose on 1 or 2 days post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID1149483 | Antitumor activity against mouse early Lewis lung carcinoma allografted in BDF1 mouse assessed as increase in host life span at 30 mg/kg, ip administered as single dose on 1 or 2 days post-tumor implantation | 1977 | Journal of medicinal chemistry, Feb, Volume: 20, Issue:2
| Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. |
| AID221726 | Dose showing lethal effects on 10% of the mice bearing lewis lung tumors. | 1984 | Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
| cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor. |
| AID23780 | Half life period in phosphate buffer (pH 7.4) | 1984 | Journal of medicinal chemistry, Jan, Volume: 27, Issue:1
| cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |