Page last updated: 2024-10-24

positive regulation of phospholipid biosynthetic process

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. [GOC:mah]

Positive regulation of phospholipid biosynthetic process involves a complex interplay of molecular events that fine-tune the production of phospholipids, essential components of cell membranes. This process is crucial for maintaining cellular integrity, signaling, and various cellular functions. Key steps in this regulation include:

**1. Transcriptional Regulation:**
- Specific transcription factors bind to regulatory elements in the DNA, activating or repressing the expression of genes encoding enzymes involved in phospholipid biosynthesis.
- Examples include SREBPs (sterol regulatory element-binding proteins), which control the synthesis of fatty acids and phospholipids.

**2. Post-translational Modifications:**
- Enzymes like kinases and phosphatases modify the activity of proteins involved in phospholipid synthesis.
- Phosphorylation events can alter the activity of enzymes, leading to increased or decreased phospholipid production.

**3. Feedback Mechanisms:**
- The levels of specific phospholipids, as well as cellular lipid content, can feedback and regulate their own synthesis.
- This feedback control ensures that phospholipid levels remain within a certain range, crucial for maintaining membrane homeostasis.

**4. Signaling Pathways:**
- Various signaling pathways, such as growth factor signaling, insulin signaling, and stress response pathways, can influence phospholipid biosynthesis.
- These pathways activate or deactivate specific enzymes or transcription factors, impacting phospholipid production.

**5. Cellular Localization:**
- The localization of enzymes involved in phospholipid synthesis within the cell is crucial for proper function.
- Specific membrane-bound organelles, like the endoplasmic reticulum, are critical sites for phospholipid biosynthesis.

**6. Interaction with Other Metabolic Pathways:**
- Phospholipid biosynthesis is closely intertwined with other metabolic pathways, such as fatty acid synthesis and cholesterol metabolism.
- These interconnections ensure a coordinated regulation of lipid production and cellular metabolism.

Overall, positive regulation of phospholipid biosynthetic process is a dynamic process involving multiple layers of regulation, ensuring the precise and efficient production of phospholipids required for cellular health and function.'
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Proteins (1)

ProteinDefinitionTaxonomy
Fatty acid-binding protein, heartA fatty acid-binding protein, heart that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05413]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
truxillic acidtruxillic acid: RN given refers to cpd with unspecified isomeric designation; structure
cocainecocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.

Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid
adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
linoleic acidlinoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.

Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)
octadecadienoic acid;
omega-6 fatty acid
algal metabolite;
Daphnia galeata metabolite;
plant metabolite
HTS 01037ring assembly;
thiophenes
bms 309403