GW 2433: binds peroxisome proliferator-activated receptor alpha (PPARalpha); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
---|---|
PubMed CID | 1517 |
CHEMBL ID | 435278 |
SCHEMBL ID | 2028308 |
MeSH ID | M0286788 |
Synonym |
---|
gtpl2716 |
gw-2433 |
gw 2433 |
bdbm28662 |
chembl435278 , |
[3h]gw 2433 |
2-[4-(3-{[2-(2-chloro-6-fluorophenyl)ethyl][(2,3-dichlorophenyl)carbamoyl]amino}propyl)phenoxy]-2-methylpropanoic acid |
gw2433 |
2-[4-[3-[2-(2-chloro-6-fluorophenyl)ethyl-[(2,3-dichlorophenyl)carbamoyl]amino]propyl]phenoxy]-2-methylpropanoic acid |
SCHEMBL2028308 |
227941-61-9 |
YMWJDWJXIXITMD-UHFFFAOYSA-N , |
2-(4-{3-[1-[2-(2-chloro-6-fluoro-phenyl)-ethyl]-3-(2,3-dichloro-phenyl)-ureido]-propyl}-phenoxy)-2-methyl-propionic |
Q27077939 |
AKOS040748501 |
GW 2433 is an effective radioligand for use in PPARdelta competition-binding assays.
Excerpt | Reference | Relevance |
---|---|---|
"[3H]GW 2433 is an effective radioligand for use in PPARdelta competition-binding assays." | ( Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Blanchard, SG; Brown, PJ; Charifson, PS; Fivush, AM; Kliewer, SA; Lehmann, JM; Orband-Miller, L; Parks, DJ; Smith-Oliver, TA; Sternbach, DD; Tomkinson, NC; Wade, LE; Willson, TM, 1997) | 0.78 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.1367 | 0.0000 | 1.2626 | 10.0000 | AID141908; AID141913 |
Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.1367 | 0.0000 | 0.7646 | 10.0000 | AID141908; AID141913 |
Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.1367 | 0.0000 | 0.9905 | 10.0000 | AID141908; AID141913 |
Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.1367 | 0.0000 | 1.0528 | 10.0000 | AID141908; AID141913 |
Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | EC50 (µMol) | 1.1367 | 0.0000 | 1.1605 | 10.0000 | AID141908; AID141913 |
Peroxisome proliferator-activated receptor alpha | Mus musculus (house mouse) | EC50 (µMol) | 0.2700 | 0.0002 | 1.3971 | 10.0000 | AID141903 |
Peroxisome proliferator-activated receptor delta | Mus musculus (house mouse) | EC50 (µMol) | 0.4100 | 0.0200 | 1.5350 | 7.2000 | AID141908 |
Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 (µMol) | 2.5000 | 0.0000 | 0.9922 | 10.0000 | AID91246 |
Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | EC50 (µMol) | 1.5000 | 0.0003 | 1.6542 | 10.0000 | AID141913 |
Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | EC50 (µMol) | 0.1900 | 0.0002 | 0.8460 | 9.1000 | AID91241 |
Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 (µMol) | 0.1700 | 0.0006 | 1.6074 | 10.0000 | AID91237 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID141908 | Agonist activity for murine PPAR delta receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID141913 | Agonist activity for murine PPAR gamma receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID91241 | Agonist activity for Human PPAR delta receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID91237 | Agonist activity for Human PPAR alpha receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID141903 | Agonist activity for murine PPAR alpha receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID91246 | Agonist activity for Human PPAR gamma receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID1346790 | Human Peroxisome proliferator-activated receptor-beta/delta (1C. Peroxisome proliferator-activated receptors) | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4 | The PPARs: from orphan receptors to drug discovery. |
AID1346790 | Human Peroxisome proliferator-activated receptor-beta/delta (1C. Peroxisome proliferator-activated receptors) | 1997 | Chemistry & biology, Dec, Volume: 4, Issue:12 | Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (28.57) | 18.2507 |
2000's | 5 (71.43) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.34) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (14.29%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (85.71%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |