Page last updated: 2024-10-06

Fatty acid metabolism

Proteins (108)

ProteinSynonymsTaxonomy
Elongation of very long chain fatty acids protein 7EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL7; ELOVL fatty acid elongase 7; ELOVL FA elongase 7; Very long chain 3-ketoacyl-CoA synthase 7; Very long chain 3-oxoacyl-CoA synthase 7Homo sapiens (human)
Trifunctional enzyme subunit alpha, mitochondrial78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; 2.3.1.-; TP-alphaHomo sapiens (human)
Prostaglandin reductase 2PRG-2; EC 1.3.1.48; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1Homo sapiens (human)
Very long-chain acyl-CoA synthetaseVLACS; VLCS; EC 6.2.1.-; Arachidonate--CoA ligase; 6.2.1.15; Fatty acid transport protein 2; FATP-2; Fatty-acid-coenzyme A ligase, very long-chain 1; Long-chain-fatty-acid--CoA ligase; 6.2.1.3; Phytanate--CoA ligase; 6.2.1.24; Solute carrier family 27 memHomo sapiens (human)
Fatty-acid amide hydrolase 1EC 3.5.1.99; Anandamide amidohydrolase 1; Fatty acid ester hydrolase; 3.1.1.-; Oleamide hydrolase 1Homo sapiens (human)
Prostaglandin E synthaseEC 5.3.99.3; Glutathione peroxidase PTGES; 1.11.1.-; Glutathione transferase PTGES; 2.5.1.18; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 proteinHomo sapiens (human)
Solute carrier family 22 member 5High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2Homo sapiens (human)
Polyunsaturated fatty acid 5-lipoxygenaseEC 1.13.11.-; Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase; 1.13.11.34Homo sapiens (human)
Arachidonate 5-lipoxygenase-activating proteinFLAP; MK-886-binding proteinHomo sapiens (human)
Prostaglandin G/H synthase 1EC 1.14.99.1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1Homo sapiens (human)
Multidrug resistance-associated protein 1 EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporterHomo sapiens (human)
Prostaglandin G/H synthase 2EC 1.14.99.1; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2Homo sapiens (human)
Aldo-keto reductase family 1 member C3EC 1.1.1.-; EC 1.1.1.210; EC 1.1.1.53; EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase type 5; 17-beta-HSD 5; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 1.1.1.357; Chlordecone reductase homolog HAKRb; DiHomo sapiens (human)
MAP kinase-activated protein kinase 2MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MAPKAPK-2; MK-2; MK2; EC 2.7.11.1Homo sapiens (human)
Fatty acid synthaseEC 2.3.1.85; Type I fatty acid synthaseHomo sapiens (human)
Stearoyl-CoA desaturase 5EC 1.14.19.1; Acyl-CoA-desaturase 4; HSCD5; Stearoyl-CoA 9-desaturase; Stearoyl-CoA desaturase 2Homo sapiens (human)
Peroxisomal carnitine O-octanoyltransferaseCOT; EC 2.3.1.137Homo sapiens (human)
Malonate--CoA ligase ACSF3, mitochondrialEC 6.2.1.n3; Acyl-CoA synthetase family member 3Homo sapiens (human)
Enoyl-CoA hydratase, mitochondrialEC 4.2.1.17; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEHHomo sapiens (human)
Trifunctional enzyme subunit beta, mitochondrialTP-betaHomo sapiens (human)
ATP-citrate synthaseEC 2.3.3.8; ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzymeHomo sapiens (human)
Stearoyl-CoA desaturasehSCD1; EC 1.14.19.1; Acyl-CoA desaturase; Delta(9)-desaturase; Delta-9 desaturase; Fatty acid desaturaseHomo sapiens (human)
Hematopoietic prostaglandin D synthaseH-PGDS; EC 5.3.99.2; GST class-sigma; Glutathione S-transferase; 2.5.1.18; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomeraseHomo sapiens (human)
Leukotriene A-4 hydrolaseLTA-4 hydrolase; EC 3.3.2.6; Leukotriene A(4) hydrolase; Tripeptide aminopeptidase LTA4H; 3.4.11.4Homo sapiens (human)
Polyunsaturated fatty acid lipoxygenase ALOX1512/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; 12-LOX; 1.13.11.31; Arachidonate 15-lipoxygenase; 15-LOX; 15-LOX-1; 1.13.11.33; Arachidonate omega-6 lipoxygenase; Hepoxilin A3 synthase Alox15; 1.13.11.-; Linoleate 13S-lipoxygenase; 1.13.Homo sapiens (human)
Carbonyl reductase [NADPH] 1EC 1.1.1.184; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; 1.1.1.196; 1.1.1.197; 20-beta-hydroxysteroid dehydrogenase; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; PG-9-KR; Prostaglandin-E(2) 9-reductase; 1.1.1.189; Short chainHomo sapiens (human)
Retinoic acid receptor RXR-alphaNuclear receptor subfamily 2 group B member 1; Retinoid X receptor alphaHomo sapiens (human)
Thromboxane-A synthase TXA synthase; TXS; EC 5.3.99.5; Cytochrome P450 5A1; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152Homo sapiens (human)
Bifunctional epoxide hydrolase 2Homo sapiens (human)
Peroxisome proliferator-activated receptor deltaPPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-betaHomo sapiens (human)
Acetyl-CoA carboxylase 1ACC1; EC 6.4.1.2; Acetyl-Coenzyme A carboxylase alpha; ACC-alphaHomo sapiens (human)
Medium-chain specific acyl-CoA dehydrogenase, mitochondrialMCAD; EC 1.3.8.7; Medium chain acyl-CoA dehydrogenase; MCADHHomo sapiens (human)
Long-chain-fatty-acid--CoA ligase 1EC 6.2.1.3; Acyl-CoA synthetase 1; ACS1; Arachidonate--CoA ligase; 6.2.1.15; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; Phytanate-Homo sapiens (human)
Very long-chain specific acyl-CoA dehydrogenase, mitochondrialVLCAD; EC 1.3.8.9Homo sapiens (human)
Serum paraoxonase/lactonase 3EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1Homo sapiens (human)
Acyl-CoA dehydrogenase family member 10ACAD-10; EC 1.3.99.-Homo sapiens (human)
Dipeptidase 1EC 3.4.13.19; Beta-lactamase; 3.5.2.6; Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDPHomo sapiens (human)
Propionyl-CoA carboxylase alpha chain, mitochondrialPCCase subunit alpha; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit alphaHomo sapiens (human)
Propionyl-CoA carboxylase beta chain, mitochondrialPCCase subunit beta; EC 6.4.1.3; Propanoyl-CoA:carbon dioxide ligase subunit betaHomo sapiens (human)
Polyunsaturated fatty acid lipoxygenase ALOX15B15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase B; 15-LOX-B; 1.13.11.33; Arachidonate 15-lipoxygenase type II; Linoleate 13-lipoxygenase 15-LOb; 1.13.11.-Homo sapiens (human)
Acyl-CoA (8-3)-desaturaseEC 1.14.19.44; Delta(5) fatty acid desaturase; D5D; Delta(5) desaturase; Delta-5 desaturase; Fatty acid desaturase 1Homo sapiens (human)
Acyl-CoA 6-desaturaseEC 1.14.19.3; Delta(6) fatty acid desaturase; D6D; Delta(6) desaturase; Delta-6 desaturase; Fatty acid desaturase 2Homo sapiens (human)
Serum paraoxonase/arylesterase 1PON 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1Homo sapiens (human)
Elongation of very long chain fatty acids protein 2EC 2.3.1.199; 3-keto acyl-CoA synthase ELOVL2; ELOVL fatty acid elongase 2; ELOVL FA elongase 2; Very long chain 3-ketoacyl-CoA synthase 2; Very long chain 3-oxoacyl-CoA synthase 2Homo sapiens (human)
Mitochondrial carnitine/acylcarnitine carrier proteinCarnitine/acylcarnitine translocase; CAC; Solute carrier family 25 member 20Homo sapiens (human)
Fatty-acid amide hydrolase 2EC 3.5.1.99; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2Homo sapiens (human)
Lysosomal thioesterase PPT2PPT-2; EC 3.1.2.-; S-thioesterase G14Homo sapiens (human)
Enoyl-CoA delta isomerase 1, mitochondrialEC 5.3.3.8; 3,2-trans-enoyl-CoA isomerase; Delta(3),Delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Dodecenoyl-CoA isomeraseHomo sapiens (human)
Alpha-methylacyl-CoA racemase EC 5.1.99.4; 2-methylacyl-CoA racemaseHomo sapiens (human)
Dipeptidase 2EC 3.4.13.19Homo sapiens (human)
Dipeptidase 3EC 3.4.13.19Homo sapiens (human)
Acyl carrier protein, mitochondrialACP; CI-SDAP; NADH-ubiquinone oxidoreductase 9.6 kDa subunitHomo sapiens (human)
Arachidonate 12-lipoxygenase, 12R-type12R-LOX; 12R-lipoxygenase; EC 1.13.11.-; Epidermis-type lipoxygenase 12Homo sapiens (human)
Phosphatidylcholine transfer proteinPC-TP; START domain-containing protein 2; StARD2; StAR-related lipid transfer protein 2Homo sapiens (human)
5'-AMP-activated protein kinase subunit beta-2AMPK subunit beta-2Homo sapiens (human)
15-hydroxyprostaglandin dehydrogenase [NAD(+)]15-PGDH; EC 1.1.1.141; Prostaglandin dehydrogenase 1; Short chain dehydrogenase/reductase family 36C member 1Homo sapiens (human)
Polyunsaturated fatty acid lipoxygenase ALOX12EC 1.13.11.-; Arachidonate (12S)-lipoxygenase; 12S-LOX; 12S-lipoxygenase; 1.13.11.31; Arachidonate (15S)-lipoxygenase; 1.13.11.33; Linoleate (13S)-lipoxygenase; Lipoxin synthase 12-LO; 3.3.2.-; Platelet-type lipoxygenase 12Homo sapiens (human)
Carnitine O-palmitoyltransferase 2, mitochondrialEC 2.3.1.21; Carnitine palmitoyltransferase II; CPT IIHomo sapiens (human)
Cytosolic phospholipase A2cPLA2; Phospholipase A2 group IVAHomo sapiens (human)
Palmitoyl-protein thioesterase 1PPT-1; EC 3.1.2.22; Palmitoyl-protein hydrolase 1Homo sapiens (human)
5'-AMP-activated protein kinase catalytic subunit alpha-2AMPK subunit alpha-2; EC 2.7.11.1; Acetyl-CoA carboxylase kinase; ACACA kinase; 2.7.11.27; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; 2.7.11.31Homo sapiens (human)
Leukotriene C4 synthaseLTC4 synthase; EC 4.4.1.20; Glutathione S-transferase LTC4; 2.5.1.-; Leukotriene-C(4) synthase; Leukotriene-C4 synthaseHomo sapiens (human)
Acyl-CoA wax alcohol acyltransferase 1EC 2.3.1.75; Diacylglycerol O-acyltransferase 2-like protein 3; Diacylglycerol acyltransferase 2; Long-chain-alcohol O-fatty-acyltransferase 1Homo sapiens (human)
Hydroxyacid oxidase 2HAOX2; EC 1.1.3.15; (S)-2-hydroxy-acid oxidase, peroxisomal; Cell growth-inhibiting gene 16 protein; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidaseHomo sapiens (human)
5'-AMP-activated protein kinase subunit gamma-2AMPK gamma2; AMPK subunit gamma-2; H91620pHomo sapiens (human)
Glutathione hydrolase 1 proenzymeEC 3.4.19.13; Gamma-glutamyltransferase 1; Gamma-glutamyltranspeptidase 1; GGT 1; 2.3.2.2; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
Carnitine O-acetyltransferaseCarnitine acetylase; EC 2.3.1.137; EC 2.3.1.7; Carnitine acetyltransferase; CAT; CrATHomo sapiens (human)
Phytanoyl-CoA dioxygenase, peroxisomalEC 1.14.11.18; Phytanic acid oxidase; Phytanoyl-CoA alpha-hydroxylase; PhyHHomo sapiens (human)
Peroxisomal bifunctional enzymePBE; PBFE; L-bifunctional protein; LBP; Multifunctional enzyme 1; MFE1Homo sapiens (human)
Peroxisomal multifunctional enzyme type 2MFE-2; 17-beta-hydroxysteroid dehydrogenase 4; 17-beta-HSD 4; D-bifunctional protein; DBP; Multifunctional protein 2; MFP-2; Short chain dehydrogenase/reductase family 8C member 1Homo sapiens (human)
Prostaglandin-H2 D-isomeraseEC 5.3.99.2; Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; Lipocalin-type prostaglandin-D synthase; L-PGDS; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2Homo sapiens (human)
Prostaglandin reductase 1PRG-1; 15-oxoprostaglandin 13-reductase; 1.3.1.48; Dithiolethione-inducible gene 1 protein; D3T-inducible gene 1 protein; DIG-1; Leukotriene B4 12-hydroxydehydrogenase; NAD(P)H-dependent alkenal/one oxidoreductase; 1.3.1.74Homo sapiens (human)
Enoyl-[acyl-carrier-protein] reductase, mitochondrialEC 1.3.1.104; 2-enoyl thioester reductase; Nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1Homo sapiens (human)
Methylmalonyl-CoA epimerase, mitochondrialEC 5.1.99.1; DL-methylmalonyl-CoA racemaseHomo sapiens (human)
Peroxisomal acyl-coenzyme A oxidase 2EC 1.17.99.3; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCoxHomo sapiens (human)
Sterol carrier protein 2SCP-2; Acetyl-CoA C-myristoyltransferase; 2.3.1.155; Non-specific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; 2.3.1.176; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; 2.3.1.16; SCP-chi; SCPX; Sterol carrier protein X; SCP-X; Straight-Homo sapiens (human)
Peroxisomal acyl-coenzyme A oxidase 3EC 1.3.3.6; Branched-chain acyl-CoA oxidase; BRCACox; Pristanoyl-CoA oxidaseHomo sapiens (human)
Serum paraoxonase/arylesterase 2PON 2; EC 3.1.1.2; EC 3.1.1.81; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2Homo sapiens (human)
Acyl-CoA dehydrogenase family member 11ACAD-11; EC 1.3.8.-Homo sapiens (human)
Malonyl-CoA-acyl carrier protein transacylase, mitochondrialMCT; EC 2.3.1.39; Mitochondrial malonyl CoA:ACP acyltransferase; Mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferaseHomo sapiens (human)
Short-chain specific acyl-CoA dehydrogenase, mitochondrialSCAD; EC 1.3.8.1; Butyryl-CoA dehydrogenaseHomo sapiens (human)
Acyl-coenzyme A thioesterase 8Acyl-CoA thioesterase 8; EC 3.1.2.1; EC 3.1.2.11; EC 3.1.2.2; EC 3.1.2.3; EC 3.1.2.5; Choloyl-coenzyme A thioesterase; 3.1.2.27; HIV-Nef-associated acyl-CoA thioesterase; Peroxisomal acyl-CoA thioesterase 2; PTE-2; Peroxisomal acyl-coenzyme A thioester hyHomo sapiens (human)
S-acyl fatty acid synthase thioesterase, medium chainEC 3.1.2.14; Augmented in rheumatoid arthritis 1; AURA1; Oleoyl-ACP hydrolase; Thioesterase 2; TE2; Thioesterase II; Thioesterase domain-containing protein 1Homo sapiens (human)
Long-chain specific acyl-CoA dehydrogenase, mitochondrialLCAD; EC 1.3.8.8Homo sapiens (human)
Thyroid hormone-inducible hepatic proteinSpot 14 protein; S14; SPOT14Homo sapiens (human)
Hydroxyacyl-thioester dehydratase type 2, mitochondrialHsHTD2; EC 4.2.1.59; 3-hydroxyacyl-[acyl-carrier-protein] dehydrataseHomo sapiens (human)
ATP-binding cassette sub-family D member 1EC 7.6.2.4; Adrenoleukodystrophy protein; ALDPHomo sapiens (human)
Prostamide/prostaglandin F synthaseProstamide/PG F synthase; Prostamide/PGF synthase; EC 1.11.1.20; Peroxiredoxin-like 2B; Protein FAM213BHomo sapiens (human)
Medium-chain acyl-CoA ligase ACSF2, mitochondrialEC 6.2.1.2Homo sapiens (human)
Nucleoside diphosphate-linked moiety X motif 19Nudix motif 19; EC 3.6.1.-Homo sapiens (human)
Peroxisomal membrane protein PMP3434 kDa peroxisomal membrane protein; Solute carrier family 25 member 17Homo sapiens (human)
3-ketoacyl-CoA thiolase, peroxisomalEC 2.3.1.16; Acetyl-CoA C-myristoyltransferase; 2.3.1.155; Acetyl-CoA acyltransferase; 2.3.1.9; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolaseHomo sapiens (human)
Peroxisomal coenzyme A diphosphatase NUDT7EC 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 7; Nudix motif 7Homo sapiens (human)
Glutathione hydrolase 5 proenzymeEC 3.4.19.13; Gamma-glutamyl transpeptidase-related enzyme; GGT-rel; Gamma-glutamyltransferase 5; GGT 5; 2.3.2.2; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase; 3.4.19.14Homo sapiens (human)
3-ketoacyl-CoA thiolase, mitochondrialEC 2.3.1.16; Acetyl-CoA acetyltransferase; 2.3.1.9; Acetyl-CoA acyltransferase; Acyl-CoA hydrolase, mitochondrial; 3.1.2.-; 3.1.2.1; 3.1.2.2; Beta-ketothiolase; Mitochondrial 3-oxoacyl-CoA thiolase; T1Homo sapiens (human)
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrialEC 1.3.1.124; 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH]; Short chain dehydrogenase/reductase family 18C member 1Homo sapiens (human)
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialHCDH; EC 1.1.1.35; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenaseHomo sapiens (human)
Solute carrier family 27 member 3EC 6.2.1.-; Arachidonate--CoA ligase; 6.2.1.15; Long-chain fatty acid transport protein 3; FATP-3; Fatty acid transport protein 3; Very long-chain acyl-CoA synthetase homolog 3; VLCS-3Homo sapiens (human)
Carbonyl reductase family member 4EC 1.-.-.-; 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit; KAR beta subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.-; Quinone reductase CBR4; Short chain dehydrogenase/reductase family 45C member 1Homo sapiens (human)
Estradiol 17-beta-dehydrogenase 8EC 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit; KAR alpha subunit; 3-oxoacyl-[acyl-carrier-protein] reductase; 1.1.1.-; Protein Ke6; Ke-6; Really interesting new gene 2 proteinHomo sapiens (human)
Acyl-CoA-binding domain-containing protein 6Homo sapiens (human)
Peroxisomal trans-2-enoyl-CoA reductaseTERP; EC 1.3.1.38; 2,4-dienoyl-CoA reductase-related protein; DCR-RP; HPDHase; Short chain dehydrogenase/reductase family 29C member 1; pVI-ARLHomo sapiens (human)
Hydroperoxide isomerase ALOXE3Epidermis-type lipoxygenase 3; Epidermal LOX-3; e-LOX-3; eLOX-3; Hydroperoxy dehydratase ALOXE3; Hydroperoxy icosatetraenoate dehydratase; 4.2.1.152; Hydroperoxy icosatetraenoate isomerase; 5.4.4.7Homo sapiens (human)
Mid1-interacting protein 1Gastrulation-specific G12-like protein; Mid1-interacting G12-like protein; Protein STRAIT11499; Spot 14-related protein; S14R; Spot 14-RHomo sapiens (human)
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]pDCR; EC 1.3.1.124; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1Homo sapiens (human)
Acyl-coenzyme A oxidase-like proteinAcyl-CoA oxidase-like protein; EC 1.3.3.-Homo sapiens (human)
2-hydroxyacyl-CoA lyase 1EC 4.1.2.n2; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2Homo sapiens (human)
ATPase MORC2EC 3.6.1.-; MORC family CW-type zinc finger protein 2; Zinc finger CW-type coiled-coil domain protein 1Homo sapiens (human)

Compounds (127)

CompoundDescription
hydronium ion
n-Butyrate
GlutathioneA tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Thiamine PyrophosphateThe coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.
Succinate
acetic acidProduct of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
NADH
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
citric acid, anhydrous
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Orthophosphate
Glutathione DisulfideA GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
tretinoinAn important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
dinoprostoneThe most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
dinoprostA naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
linoleic acidA doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed)
alpha-linolenic acidA fatty acid that is found in plants and involved in the formation of prostaglandins.
epoprostenolA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).
adenosine diphosphateAdenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.
hydrogen carbonate
Hydrogen PeroxideA strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
MagnesiumA metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
SodiumA member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
WaterA clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
palmitic acidA common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.
succinyl-coenzyme A
1,5-dihydro-FADchromophore component of E coli DNA photolyase
hexanoyl-coenzyme A
salicylatesThe salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
stearidonic acidRN given refers to cpd with unknown MF; 18:4 n-3 fatty acid
cobamamide
propionylcarnitineRN given refers to cpd without isomeric designation
malondialdehydeThe dialdehyde of malonic acid.
palmitoylcarnitineA long-chain fatty acid ester of carnitine which facilitates the transfer of long-chain fatty acids from cytoplasm into mitochondria during the oxidation of fatty acids.
3-oxopristanoyl-coenzyme A
phytanoyl-coenzyme A
s-tetradecanoyl-coenzyme a
hydroxyphytanoyl-coenzyme Aan intermediate in the alpha-oxidation of phytanic acid in rat liver peroxisomes; its formation is enhanced by dioxygenase cofactors
pristanalstructure given in first source
adenosine monophosphateAdenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
NADPNicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed)
alpha-Ketoglutarate
OxaloacetateAn anionic form of oxaloacetic acid.
decanoyl-coenzyme A
formate
carnitineA constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism.
formyl-coenzyme a
3-ketohexanoyl-coenzyme A
prostaglandin h2A cyclic endoperoxide intermediate produced by the action of CYCLOOXYGENASE on ARACHIDONIC ACID. It is further converted by a series of specific enzymes to the series 2 prostaglandins.
octanoyl-coenzyme A
n(1)-methylnicotinamideRN given refers to parent cpd
leukotriene a4(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
leukotriene b4The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
leukotriene c4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
thromboxane a2An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
15-keto-5,8,11,13-eicosatetraenoic acidRN given refers to (E,Z,Z,Z)-isomer; RN for cpd without isomeric designation not available 3/88
15-hydroxy-5,8,11,13-eicosatetraenoic acidpotent & selective inhibitor of platelet lipoxygenase; RN given refers to cpd without isomeric designation
5-hydroxy-6,8,11,14-eicosatetraenoic acid
5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acidRN given refers to (S-(R*,R*-(E,E,Z,Z)))-isomer
arachidonic acid 5-hydroperoxide5-HPETE is used inconsistently in literature as syn for cpds with various tetraene locants; RN given refers to (6,8,11,14)-isomer; RN in CA Vol 91 Form Index for (E,Z,Z,Z)-isomer: 70968-82-0; RN for (5,8,11,13)-isomer: 71133-12-5; in Merck, arachidonic acid is the (5,8,11,14)-isomer
12-oxoleukotriene B4structure given in first source
20-carboxyleukotriene b4metabolite of leukotriene B4
leukotriene d4One of the biologically active principles of SRS-A. It is generated from LEUKOTRIENE C4 after partial hydrolysis of the peptide chain, i.e., cleavage of the gamma-glutamyl portion. Its biological actions include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability. (From Dictionary of Prostaglandins and Related Compounds, 1990)
leukotriene e4A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
prostaglandin a2RN given refers to (5Z,13E,15S)-isomer
prostaglandin b2RN given refers to (5Z,13E,15S)-isomer
prostaglandin g2
9-deoxy-delta-9-prostaglandin d2has potent antineoplastic & weak smooth muscle contracting activities; structure given in first source
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin d2PGD2 metabolite in human plasma
DinoprostA naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
6-ketoprostaglandin f1 alphaThe physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.
11-dehydro-thromboxane b2structure given in first source
arachidonic acid omega-9 hydroperoxide
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (s)-(e,z,z,z)-isomer
anandamide
thromboxane b2A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).
12-hydroxy-5,8,10-heptadecatrienoic acidmetabolite of arachidonic acid in blood platelet suspension; RN given refers to cpd without isomeric designation
12-hydroxy-5,8,10,14-eicosatetraenoic acidA lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
20-hydroxy-5,8,11,14-eicosatetraenoic acidstimulator of renal sodium, potassium atpase; RN given is for the (all-Z) isomer
5-oxo-6,8,11,14-eicosatetraenoic acidRN given is for cpd without isomeric designation; an arachidonate metabolite which stimulates neutrophils to mobilize Ca and promotes PMN degranulation responses
12-keto-5,8,11,13-eicosatetraenoic acid
15-hydroxy-5,8,11,13-eicosatetraenoic acidpotent & selective inhibitor of platelet lipoxygenase; RN given refers to cpd without isomeric designation
5,6-epoxy-8,11,14-eicosatrienoic acidRN given refers to cpd without isomeric designation
8-hydroxy-11,12-epoxyeicosa-5,9,14-trienoic acid
15-deoxy-delta(12,14)-prostaglandin j215-deoxy-PGJ2 is also available; check for double bonds (indicated by delta) at 12 and 14 positions
glutamate
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
oleoyl-coenzyme aRN given refers to (Z)-isomer
linoleoyl-coenzyme ARN from 9th CI Form Index & given refers to cpd without isomeric designation
18-carboxy-19,20-dinorleukotriene B4structure given in first source
2,4-decadienoyl-coenzyme A
20-aldehyde leukotriene B4
ethanolamineA viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.
2-hydroxyhexadecanoic acidRN given refers to cpd without isomeric designation
3-hydroxybutyryl-coenzyme A, (S)-isomer
5-hydroxy-6,8,11,14-eicosatetraenoic acid
behenyl-coenzyme A
beta-ketohexadecanoyl-coenzyme A
19-hydroxy-5,8,11,14-eicosatetraenoic acidpotent stimulator of renal sodium, potassium atpase; RN given is for the (all-Z) isomer
pristanic acid
4-decenoyl-coenzyme A
3-hydroxyoctadecanoyl-coenzyme A
Coenzyme A
lauroyl-coenzyme A
lignoceroyl-coenzyme A
arachidonyl-coenzyme A
3-ketostearoyl-coenzyme A
phytanic acidA 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.
decanoic acid
eoxin c4structure in first source
eoxin D4
prostaglandin d2The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
acetoacetyl CoA
Acetyl Coenzyme AAcetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
butyryl-coenzyme A
Palmitoyl Coenzyme AA fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.
Malonyl Coenzyme AA coenzyme A derivative which plays a key role in the fatty acid synthesis in the cytoplasmic and microsomal systems.
stearoyl-coenzyme A
Flavin-Adenine DinucleotideA condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)
eoxin E4
creolinfrom refined coal tar oils
propionyl-coenzyme aRN given refers to parent cpd