linoleic-acid and Celiac-Disease

Patients with cystic fibrosis who have steatorrhea frequently are underweight and have essential fatty acid (EFA) depletion, which is associated with a poor clinical course. It has been stated that poor EFA status is difficult to correct in patients with cystic fibrosis, and an impaired EFA metabolism with reduced synthesis of long-chain polyunsaturated fatty acids has been proposed. In this study, the effects of an oral energy supplement rich in linoleic acid were investigated in patients with cystic fibrosis who had a body weight below 95% of normal for height.. Thirty-six patients (16 girls) more than 4 years of age were randomized either to a control group (n = 20, age 13.3 +/- 3.8 years, mean +/- SD) receiving intensive dietary counseling only, or an intervention group (n = 16, age, 10.4 +/- 4.3 years) treated for 3 months with dietary counseling plus 628 +/- 254 mL (= kcal) per day of an energy supplement rich in fat (31% of energy) and linoleic acid (16% of energy).. In contrast to the control group, the patients with supplemented diets achieved significant increases of energy intake (2189 +/- 731 kcal/day vs. 2733 +/- 762 kcal/day), weight for height (82.8% +/- 8.6% vs. 84.8% +/- 9.6% of normal), and body fat (5.1 +/- 1.7 kg vs. 5.8 +/- 2.2 kg) as well as the initially low values of plasma phospholipid linoleic acid (11.8% +/- 1.1% vs. 17.6% +/- 1.6% of total phospholipid fatty acids) and its main metabolite arachidonic acid (4.4% +/- 0.4% vs. 5.9% +/- 0.3%).. Patients with cystic fibrosis with low body weight and poor EFA status benefit from EFA-rich energy supplements and can synthesize arachidonic acid from the precursor linoleic acid.

Topics: Adolescent; Body Weight; Celiac Disease; Child; Cystic Fibrosis; Dietary Supplements; Energy Intake; Fatty Acids, Essential; Female; Humans; Linoleic Acid; Male

Topics: Abetalipoproteinemia; Adipose Tissue; Ataxia; Celiac Disease; Child; Cholesterol; Chylomicrons; Consanguinity; Electrons; Electrophoresis; Erythrocytes; Genetics, Medical; Glycerides; Humans; Jejunum; Linoleic Acid; Lipid Metabolism; Lipids; Lipoproteins; Lipoproteins, LDL; Liver Diseases; Microscopy; Microscopy, Electron; Mucous Membrane; Pathology; Phospholipids; Protein Deficiency; Proteins; Retinitis Pigmentosa

Topics: Abetalipoproteinemia; Adenine Nucleotides; Adenosine Triphosphate; Autoimmune Diseases; Blood Protein Disorders; Celiac Disease; Cholesterol; Congenital Abnormalities; Erythrocytes; Glucosephosphate Dehydrogenase; Hemoglobinometry; Hemolysis; Linoleic Acid; Lipid Metabolism; Lipoproteins; Metabolism; Methemoglobin; Neurologic Manifestations; Osmosis; Phospholipids; Research

Topics: Anemia; Anemia, Pernicious; Butter; Celiac Disease; Cottonseed Oil; Diabetes Mellitus; Dietary Fats; Fats; Feces; Gastroenterostomy; Geriatrics; Glycerides; Glycerol; Humans; Intestinal Absorption; Linoleic Acid; Stearic Acids; Steatorrhea

Topics: Abetalipoproteinemia; Adolescent; Celiac Disease; Central Nervous System Diseases; Child; Cholesterol; Erythrocytes; Fatty Acids; Genetics, Medical; Humans; Immunodiffusion; Immunoelectrophoresis; Infant; Infant, Newborn; Linoleic Acid; Lipids; Lipoproteins; Phospholipids; Plasmalogens; Retinitis Pigmentosa