linoleic-acid and Glomerulonephritis

The effects of increasing two dietary polyunsaturated fatty acids, eicosapentaenoic and linoleic, on the glomerulonephritis induced by repeated injections of apoferritin in the mouse were studied. Urinary protein excretion was measured serially; serum creatinine, aortic and renal production of eicosanoids and kidney histology were measured at sacrifice at 8 weeks. Both high EPA and LA feedings were associated with lesser proteinuria, normalization of renal function and profound changes in the tissue production of prostaglandin and thromboxane, which may explain their protective effect in this model of renal disease.

Topics: Animals; Apoferritins; Creatinine; Dietary Fats; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Glomerulonephritis; Immune Complex Diseases; Linoleic Acid; Linoleic Acids; Male; Mice; Prostaglandins; Proteinuria; Thromboxane B2

In pharmacologic doses E series prostaglandins attenuate the development of immune complex nephritis. We studied the effect of the dietary prostaglandin precursor linoleic acid on murine apoferritin-induced immune complex glomerulonephritis. High, normal, or low linoleic acid diets were fed to mice for 4 weeks prior to and during the intraperitoneal apoferritin administration. A high linoleic acid diet feeding was associated with less proteinuria, less renal histologic damage, and prevented a rise in serum creatinine. We conclude that linoleic acid has a protective effect on the development of murine apoferritin-induced immune complex nephritis.

Topics: Animals; Apoferritins; Diet; Glomerulonephritis; Immune Complex Diseases; Kidney Glomerulus; Kidney Tubules; Linoleic Acid; Linoleic Acids; Male; Mice; Prostaglandins E; Proteinuria