linoleic-acid and Anxiety-Disorders

Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed the anxiolytic-like effect of a mixture of lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, elaidic acid, and linoleic acid in Wistar rats on postnatal day 28. Infant rats were subjected to the elevated plus maze, defensive burying test, and locomotor activity test. Diazepam was used as a reference anxiolytic drug. A group that was pretreated with picrotoxin was used to explore the participation of

Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Lauric Acids; Linoleic Acid; Maze Learning; Motor Activity; Myristic Acid; Oleic Acid; Oleic Acids; Palmitic Acid; Rats; Receptors, GABA-A; Stearic Acids