n-nitrosobis(2-oxobutyl)amine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

n-Nitrosobis(2-oxobutyl)amine, also known as NDBA, is a potent mutagen and animal carcinogen. It is formed through the reaction of secondary amines with nitrous acid, a process that can occur in various environments such as the human stomach, during food processing, and in the environment. The compound is particularly concerning due to its presence in certain processed meats, where it arises from the reaction of nitrites used as preservatives with secondary amines in meat. NDBA has been shown to induce tumors in animal studies and is considered a probable human carcinogen by the International Agency for Research on Cancer (IARC). Its formation and presence in food products have driven extensive research efforts to understand its formation mechanisms, its effects on human health, and develop strategies to minimize its presence in food.'

N-nitrosobis(2-oxobutyl)amine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	53725
MeSH ID	M0098775

Synonyms (6)

Synonym
2-butanone, 1,1'-(nitrosoimino)bis-
n-nitrosobis(2-oxobutyl)amine
ccris 3215
bis(2-oxobutyl)nitrosamine
77698-19-2
DTXSID80228321

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (57.14)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.32

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.32 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.40 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.32)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2	1	diazine; pyrazines	Daphnia magna metabolite
n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation	1.96	1
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	1.96	1	diol; nitrosamine; secondary alcohol	carcinogenic agent
n-nitroso(2-hydroxypropyl)(2-oxopropyl)amine N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine: structure	1.96	1
oltipraz oltipraz : A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.	2	1	1,2-dithiole; pyrazines	angiogenesis modulating agent; antimutagen; antineoplastic agent; antioxidant; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor; neurotoxin; protective agent; schistosomicide drug
n-nitrosobis(2-acetoxypropyl)amine [no description available]	1.96	1
linoleic acid Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed). linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.	2	1	octadecadienoic acid; omega-6 fatty acid	algal metabolite; Daphnia galeata metabolite; plant metabolite
alpha-linolenic acid linolenic acid : A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.. linolenate : A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of either alpha- or gamma-linolenic acid.	2	1	linolenic acid; omega-3 fatty acid	micronutrient; mouse metabolite; nutraceutical

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	1.96	1
Experimental Neoplasms [description not available]	2.38	2
Lung Neoplasms Tumors or cancer of the LUNG.	1.96	1
Cancer of Pancreas [description not available]	2.89	4
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.89	4
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.41	2
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2	1
Adenocarcinoma, Basal Cell [description not available]	2.68	3
Cancer of Liver [description not available]	2	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.68	3
Liver Neoplasms Tumors or cancer of the LIVER.	2	1
Condition, Preneoplastic [description not available]	2	1
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	2	1

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