linoleic-acid and Leukemia--Promyelocytic--Acute

linoleic-acid has been researched along with Leukemia--Promyelocytic--Acute* in 2 studies

Other Studies

2 other study(ies) available for linoleic-acid and Leukemia--Promyelocytic--Acute

Article	Year
Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. Proceedings of the National Academy of Sciences of the United States of America, 1993, Jun-01, Volume: 90, Issue:11 2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC 3.1.1.4), significantly potentiate the differentiation of HL-60 cells to macrophages that is induced by either a membrane-permeant diacylglycerol or a phorbol ester. The cell differentiation was assayed by measuring the expression of CD11b, one of the cell surface markers of macrophages, and also by the appearance of phagocytic activity. Snake venom phospholipase A2 added directly to the cells is also active for this potentiation. Neither lysophosphatidylcholine, fatty acid, nor phospholipase A2 is active unless a membrane-permeant diacylglycerol or a phorbol ester is present. The results presented provide further evidence that activation of phospholipase A2 may be intimately related to the signal transduction pathway through protein kinase C. Topics: Antigens, CD; CD11 Antigens; Cell Differentiation; Cell Line; Enzyme Activation; Fatty Acids, Nonesterified; Kinetics; Leukemia, Promyelocytic, Acute; Linoleic Acid; Linoleic Acids; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Phospholipases A; Phospholipases A2; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured	1993
Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium. Cancer letters, 1993, Aug-16, Volume: 72, Issue:1-2 The metabolism of [1-14C]linoleic acid (LA) was studied in human promyelocytic leukemia cell line HL-60, grown and differentiated in serum-free medium. Both undifferentiated and dibutyryl cyclic AMP-differentiated HL-60 cells exhibited similar patterns of conversion of LA to four other major fatty acids (i.e. 18:3, 20:3, 20:4, and 22:4). Topics: Carbon Radioisotopes; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Fatty Acids; Humans; Leukemia, Promyelocytic, Acute; Linoleic Acid; Linoleic Acids; Tumor Cells, Cultured	1993

Article

Year

Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

Proceedings of the National Academy of Sciences of the United States of America, 1993, Jun-01, Volume: 90, Issue:11

2-Lysophosphatidylcholine and cis-unsaturated fatty acids such as linoleic and linolenic acids, which are the products of the hydrolysis of phosphatidylcholine catalyzed by phospholipase A2 (EC 3.1.1.4), significantly potentiate the differentiation of HL-60 cells to macrophages that is induced by either a membrane-permeant diacylglycerol or a phorbol ester. The cell differentiation was assayed by measuring the expression of CD11b, one of the cell surface markers of macrophages, and also by the appearance of phagocytic activity. Snake venom phospholipase A2 added directly to the cells is also active for this potentiation. Neither lysophosphatidylcholine, fatty acid, nor phospholipase A2 is active unless a membrane-permeant diacylglycerol or a phorbol ester is present. The results presented provide further evidence that activation of phospholipase A2 may be intimately related to the signal transduction pathway through protein kinase C.

Topics: Antigens, CD; CD11 Antigens; Cell Differentiation; Cell Line; Enzyme Activation; Fatty Acids, Nonesterified; Kinetics; Leukemia, Promyelocytic, Acute; Linoleic Acid; Linoleic Acids; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Phospholipases A; Phospholipases A2; Protein Kinase C; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

1993

Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium.

Cancer letters, 1993, Aug-16, Volume: 72, Issue:1-2

The metabolism of [1-14C]linoleic acid (LA) was studied in human promyelocytic leukemia cell line HL-60, grown and differentiated in serum-free medium. Both undifferentiated and dibutyryl cyclic AMP-differentiated HL-60 cells exhibited similar patterns of conversion of LA to four other major fatty acids (i.e. 18:3, 20:3, 20:4, and 22:4).

Topics: Carbon Radioisotopes; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Fatty Acids; Humans; Leukemia, Promyelocytic, Acute; Linoleic Acid; Linoleic Acids; Tumor Cells, Cultured

1993