cytoskeletal protein binding

Definition

Target type: molecularfunction

Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]

Cytoskeletal protein binding is a molecular function that describes the ability of proteins to interact with components of the cytoskeleton. The cytoskeleton is a complex network of protein filaments that provides structural support, shape, and motility to cells. It is composed of three major types of filaments: microtubules, microfilaments (actin filaments), and intermediate filaments.

Cytoskeletal protein binding proteins can interact with these filaments in a variety of ways, including:

* **Direct binding:** Some proteins bind directly to the surface of cytoskeletal filaments, often through specific protein domains. For example, the motor protein kinesin binds to microtubules and uses ATP hydrolysis to move cargo along the filament.
* **Indirect binding:** Other proteins bind indirectly to cytoskeletal filaments through intermediary proteins. For example, some adaptor proteins link cytoskeletal filaments to other cellular structures, such as the plasma membrane or organelles.
* **Regulation of assembly and disassembly:** Some proteins can regulate the assembly and disassembly of cytoskeletal filaments. For example, the protein actin-depolymerizing factor (ADF) promotes the disassembly of actin filaments.

Cytoskeletal protein binding is essential for a wide range of cellular processes, including:

* **Cell shape and organization:** The cytoskeleton provides structural support to cells and helps to maintain their shape.
* **Cell motility:** The cytoskeleton is involved in cell movement, including crawling, swimming, and gliding.
* **Intracellular transport:** The cytoskeleton acts as a network of tracks for the transport of organelles, vesicles, and other cellular components.
* **Signal transduction:** The cytoskeleton can be involved in signal transduction pathways, transmitting signals from the cell surface to the interior of the cell.

The specific function of a cytoskeletal protein binding protein depends on its binding partners and its interactions with other cellular components. These interactions can be regulated by a variety of factors, including phosphorylation, ubiquitination, and other post-translational modifications.

In summary, cytoskeletal protein binding is a fundamental molecular function that plays a crucial role in a wide range of cellular processes.'
"

Proteins (4)

Compounds (25)