linoleic-acid has been researched along with Peptic-Ulcer* in 2 studies
2 other study(ies) available for linoleic-acid and Peptic-Ulcer
| Article | Year |
|---|---|
Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration.
Diets high in polyunsaturated fatty acids may protect against duodenal ulcer, possibly through inhibiting the growth of Helicobacter pylori. This hypothesis was tested in vitro by incubating H pylori microaerophilically with a range of polyunsaturated fatty acids. omega-3 Linolenic acid significantly, but reversibly, inhibited growth at 1.8, 2.5, and 5 x 10(-4) M (p < 0.01), while concentrations of 10(-3) M killed virtually all organisms, with cell lysis observed by electron microscopy. Similar inhibitory effects were seen with other polyunsaturated fatty acids, at concentrations of 2.5 x 10(-4) M the relative inhibitory potencies were oleic (C18:1) < linoleic (C18:2) < arachidonic (C20:4) < omega-3 linolenic (C18:3) = omega-6 linolenic (C18:3) = eicosapentanoic (C20:5) acid. Cell fractionation studies with 14C labelled linolenic acid showed that the linolenic acid was associated with the membrane fraction. Commonly ingested dietary polyunsaturated fatty acids inhibit the growth of H pylori in vitro, an effect which deserves further in vivo study. Topics: Diet; Dietary Fats, Unsaturated; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Helicobacter pylori; Humans; Linoleic Acid; Linoleic Acids; Peptic Ulcer | 1994 |
Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease.
Dietary linoleic acid has been implicated in the pathogenesis of peptic ulcer disease because its metabolite arachidonic acid may be converted to cytoprotective prostaglandins. In addition, it has been suggested that the falling incidence and virulence of duodenal ulcer disease is related to increased dietary polyunsaturated essential fatty acid intake. In the present study the percentage content of linoleic acid in subcutaneous adipose tissue microbiopsies were used to see whether changes in percentage of fatty acids correlate with the presence or absence of an ulcer in individual patients. No significant difference in the adipose tissue content of linoleic acid was found, ie, 11.2 +/- 0.7% (n = 15) vs 10.9 +/- 0.5% (n = 15) in patients with peptic ulcer disease and matched control subjects, respectively. Topics: Adipose Tissue; Fatty Acids; Female; Humans; Linoleic Acid; Linoleic Acids; Male; Middle Aged; Peptic Ulcer; Skin; Smoking | 1993 |