linoleic-acid and stearyl-alcohol

Highly specific and effective cancer phototherapy remains as a great challenge. Herein, a smart nanoplatform (TENAB NP) sequentially responsive to light, low pH and hypoxia is demonstrated for multi-mode imaging guided synergistic cancer therapy with negligible skin phototoxicity. Upon 808-nm laser irradiation, TENAB NPs can generate hyperthermia to melt the phase change material (PCM-LASA) coat and thereafter release chemo-drug tirapazamine (TPZ). Meanwhile, under acidic pH, photosensitizer ENAB would turn "off" its charge-transfer state, generating prominent

Topics: Animals; Drug Delivery Systems; Fatty Alcohols; Female; HeLa Cells; Humans; Linoleic Acid; Mice; Mice, Nude; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Skin; Tirapazamine