10-hydroxy-12-octadecenoic acid

Description

10-Hydroxy-12-octadecenoic acid, also known as **10-HODE**, is a **hydroxy fatty acid** formed from the **oxygenation of linoleic acid** by **12/15-lipoxygenases**. It's a naturally occurring compound found in various biological systems, including plants and animals.

**Importance for research:**

1. **Inflammation and immune response:** 10-HODE is a key mediator in **inflammatory processes**. It can activate **immune cells** and **regulate gene expression** involved in inflammation. Researchers are exploring its role in conditions like **atherosclerosis**, **rheumatoid arthritis**, and **asthma**.

2. **Apoptosis and cell death:** 10-HODE has been shown to induce **apoptosis** (programmed cell death) in certain cell types. Its role in **cancer progression** and **neurodegenerative diseases** is under investigation.

3. **Signal transduction and gene regulation:** 10-HODE can interact with **cellular receptors** and **activate signaling pathways**, affecting various cellular processes like **cell growth**, **differentiation**, and **survival**.

4. **Lipid metabolism and cardiovascular disease:** 10-HODE is implicated in **lipid metabolism**, specifically the breakdown of **triglycerides**. Research is ongoing to understand its potential role in **hyperlipidemia** and **atherosclerosis**.

5. **Oxidative stress:** 10-HODE can be generated in response to **oxidative stress** and is involved in the **regulation of antioxidant defense mechanisms**. Its role in **ageing** and **neurological disorders** is being studied.

6. **Plant defense mechanisms:** In plants, 10-HODE is part of the **jasmonic acid pathway**, which plays a vital role in **defense responses** against pathogens and herbivores.

**Overall, 10-HODE is a multifaceted lipid mediator with significant implications for a wide range of biological processes.** Its complex interactions with various cellular systems make it a valuable target for researchers exploring the mechanisms of disease and developing novel therapeutic strategies.

10-hydroxy-12-octadecenoic acid: RN given refers to cpd with unspecified double bond locant; RN for cpd with double bond in position 12 not in Chemline 3/84 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]