linoleic-acid has been researched along with osthenol* in 1 studies
1 other study(ies) available for linoleic-acid and osthenol
| Article | Year |
|---|---|
Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase.
Linoleic acid, osthol, osthenol and two polyacetylenes, falcarindiol and 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1 -yl acetate were found to be the most active compounds responsible for the inhibitory activity of the dichloromethane extract of the roots of Angelica pubescens f. biserrata on 5-lipoxygenase (5-LO) and cyclooxygenase (COX-1) in vitro. They showed prominent inhibitory effect on 5-LO with IC50 values of 27.9 microM, 36.2 microM, 43.1 microM, 9.4 microM and 24.0 microM, respectively. Linoleic acid, osthenol, falcarindiol and 11(S), 16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate exhibited inhibitory activity on COX-1 with IC50 values of 13.3 microM, 64.3 microM, 66.0 microM and 73.3 microM. Topics: Animals; Arachidonate 5-Lipoxygenase; Coumarins; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Diynes; Fatty Alcohols; Isoenzymes; Leukocytes; Linoleic Acid; Lipoxygenase Inhibitors; Male; Medicine, Chinese Traditional; Microsomes; Plant Extracts; Plant Roots; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Swine | 1998 |