Target type: molecularfunction
Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid. [GOC:lp, GOC:mah]
Oleic acid binding is a molecular function that describes the ability of a molecule to specifically interact with oleic acid. Oleic acid is an unsaturated fatty acid, a major component of many lipids, particularly triglycerides and phospholipids, found in various organisms. Its binding to proteins or other molecules often plays a critical role in cellular processes such as:
* **Membrane structure and fluidity:** Oleic acid is a key component of cell membranes, contributing to their fluidity and flexibility. Binding of oleic acid to membrane proteins can influence their conformation and function.
* **Signal transduction:** Some proteins bind oleic acid as part of signal transduction pathways, leading to changes in cellular processes.
* **Lipid metabolism:** Oleic acid binding is involved in the regulation of lipid synthesis, transport, and breakdown.
* **Enzyme activity:** Some enzymes require oleic acid binding for their activity.
* **Protein-protein interactions:** Oleic acid binding can mediate interactions between proteins, facilitating their assembly and function.
* **Cellular transport:** Oleic acid binding can be involved in the transport of fatty acids across cell membranes.
The specific mechanism of oleic acid binding varies depending on the interacting molecule. For example, some proteins have specific binding sites for oleic acid, while others interact with it through hydrophobic interactions. Oleic acid binding can involve both covalent and non-covalent interactions. The physiological consequences of oleic acid binding are diverse and depend on the specific context in which it occurs.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Fatty acid-binding protein, liver | A fatty acid-binding protein, liver that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07148] | Homo sapiens (human) |
| Fatty acid-binding protein, heart | A fatty acid-binding protein, heart that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05413] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tacrine | tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. | acridines; aromatic amine | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
| fenofibrate | Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE | aromatic ether; chlorobenzophenone; isopropyl ester; monochlorobenzenes | antilipemic drug; environmental contaminant; geroprotector; xenobiotic |
| 2-benzylaminopyridine | |||
| phytanic acid | phytanic acid : A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15. Phytanic Acid: A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency. | branched-chain saturated fatty acid; long-chain fatty acid; methyl-branched fatty acid | |
| fenofibric acid | fenofibric acid : A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate. fenofibric acid: RN given refers to parent cpd without isomeric designation; structure | aromatic ketone; chlorobenzophenone; monocarboxylic acid | drug metabolite; marine xenobiotic metabolite |
| truxillic acid | truxillic acid: RN given refers to cpd with unspecified isomeric designation; structure | ||
| oleic acid | oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry. Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed) | octadec-9-enoic acid | antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent |
| cocaine | cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. | benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid | adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic |
| linoleic acid | linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry. Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed) | octadecadienoic acid; omega-6 fatty acid | algal metabolite; Daphnia galeata metabolite; plant metabolite |
| HTS 01037 | ring assembly; thiophenes | ||
| bms 309403 |