linoleic-acid and Amnesia

Soybean transphosphatidylated phosphatidylserine (SB-tPS) was prepared from soybean phosphatidylcholine by transphosphatidylation using phospholipase D, and the fatty acids composition and pharmacological properties were compared with those of bovine brain cortex-derived phosphatidylserine (BC-PS) which was reported to improve cognitive disorders of senile dementia patients by oral administration (300 mg/day). The molecular species of SB-tPS are rich in linoleic and palmitic acids whereas those of BC-PS are stearic and oleic acids. Despite the differences in fatty acid composition, SB-tPS displayed significant activities on the increase in brain glucose concentrations in mice (79 mg/kg, i.v.) and the restoration of scopolamine-induced amnesia in rats (60 mg/kg, i.p.) as did BC-PS. These results suggest the possibility that SB-tPS may prevent and/or improve senile dementia by oral administration.

Topics: Amnesia; Animals; Blood Glucose; Brain; Brain Chemistry; Cattle; Glycine max; Linoleic Acid; Linoleic Acids; Male; Mice; Mice, Inbred ICR; Oleic Acid; Oleic Acids; Palmitic Acid; Palmitic Acids; Phosphatidylcholines; Phosphatidylserines; Rats; Rats, Sprague-Dawley; Scopolamine; Stearic Acids