Compounds > 9-oxo-10,12-octadecadienoic acid
Page last updated: 2024-12-10

9-oxo-10,12-octadecadienoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

9-oxo-10,12-octadecadienoic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

9-oxo-10E,12E-ODE : An oxooctadecadienoic acid that consists of 10E,12E-octadecadienoic acid with the oxo substituent located at position 9. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5283011
CHEMBL ID465240
CHEBI ID72843
SCHEMBL ID1234585
SCHEMBL ID2564381
MeSH IDM0172110

Synonyms (23)

Synonym
chebi:72843 ,
CHEMBL465240
(10e,12e)-9-oxooctadeca-10,12-dienoic acid
LMFA02000251
9-oxo-10e,12e-ode
9-keto-10,12-octadecadienoic acid
54665-32-6
9-oxo-10,12-odda
9-oxo-10,12-octadecadienoic acid
10,12-octadecadienoic acid, 9-oxo-
SCHEMBL1234585
SCHEMBL2564381
(10e,12e)-9-oxo-10,12-octadecadienoic acid #
LUZSWWYKKLTDHU-SIGMCMEVSA-N
9-keto-trans,trans-10,12-octadeca-dienoic acid
Q27140184
54232-58-5
9-oxo-10(e),12(e)-octadecadienoic acid
PD018777
DTXSID301347858
AKOS040762972
AKOS040738938
compound np-013728

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" acutatum, Botrytis cinerea, Fusarium oxysporum, Phomopsis obscurans, and Phomopsis viticola) in in vitro dose-response studies."( Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
Cantrell, CL; Case, BP; Duke, SO; Kniffin, TM; Mena, EE; Wedge, DE, 2008)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
oxooctadecadienoic acidAn oxo fatty acid that is obtained by oxidation of the allylic hydroxy group of any hydroxyoctadecadienoic acid during its metabolism.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1091194Antifungal activity against Colletotrichum fragariae assessed as inhibition of fungal growth at 80 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091191Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of fungal growth at 20 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091181Antifungal activity against Botryotinia fuckeliana assessed as inhibition of fungal growth measured after 72 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091177Antifungal activity against Fusarium oxysporum assessed as inhibition of fungal growth measured after 72 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091196Antifungal activity against Colletotrichum acutatum assessed as inhibition of fungal growth at 80 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091192Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of fungal growth at 80 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091200Antifungal activity against Colletotrichum acutatum assessed as inhibition of fungal growth measured after 48 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091180Antifungal activity against Colletotrichum acutatum assessed as inhibition of fungal growth measured after 72 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091203Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of fungal growth measured after 48 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091197Antifungal activity against Plasmopara viticola assessed as inhibition of fungal growth measured after 120 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091187Antifungal activity against Plasmopara viticola assessed as inhibition of fungal growth measured after 144 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091198Antifungal activity against Phomopsis obscurans assessed as inhibition of fungal growth measured after 120 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091199Antifungal activity against Fusarium oxysporum assessed as inhibition of fungal growth measured after 48 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091178Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of fungal growth measured after 72 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091179Antifungal activity against Colletotrichum fragariae assessed as inhibition of fungal growth measured after 72 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091193Antifungal activity against Colletotrichum fragariae assessed as inhibition of fungal growth at 20 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091202Antifungal activity against Colletotrichum fragariae assessed as inhibition of fungal growth measured after 48 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID1091195Antifungal activity against Colletotrichum acutatum assessed as inhibition of fungal growth at 20 ug measured after 4 to 5 days by direct bioautography2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
AID361443Inhibition of yeast aldehyde dehydrogenase at 0.5 mM by electrospray ionization-mass spectroscopy2002Journal of natural products, Nov, Volume: 65, Issue:11
Aldehyde dehydrogenase inhibitors from the mushroom Clitocybe clavipes.
AID1091201Antifungal activity against Botryotinia fuckeliana assessed as inhibition of fungal growth measured after 48 hr by 96-well microdilution assay2008Journal of agricultural and food chemistry, Jul-09, Volume: 56, Issue:13
Isolation and identification of antifungal fatty acids from the basidiomycete Gomphus floccosus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's2 (20.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.73 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
captan
Captan: One of the phthalimide fungicides.. captan : A dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops.		2.0410isoindoles;
organochlorine compound;
organosulfur compound;
phthalimide fungicide		antifungal agrochemical
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		2.110icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
linoleic acid
Linoleic Acid: A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed). linoleic acid : An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.		2.4320octadecadienoic acid;
omega-6 fatty acid		algal metabolite;
Daphnia galeata metabolite;
plant metabolite
lipoxin a4
lipoxin A4: an antifibrolytic agent; structure given in first source; a role in ASPIRIN antiinflammatory activity. lipoxin A4 : A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.		2.110hydroxy polyunsaturated fatty acid;
lipoxin;
long-chain fatty acid		human metabolite;
metabolite
9-hydroxy-10,12-octadecadienoic acid
9-hydroxy-10,12-octadecadienoic acid: RN given refers to unspecified stereoisomer. 9-HODE : A HODE that consists of (10E,12Z)-octadecadienoic acid with the hydroxy substituent located at position 9.		2.4120HODE;
octadecadienoic acid		human metabolite;
metabolite;
mouse metabolite;
plant metabolite
13-hydroxy-9,11-octadecadienoic acid
13-hydroxy-9,11-octadecadienoic acid: chemorepellant factor which maintains blood vessel wall thromboresistance; RN given refers to unspecified stereoisomer		2.0810octadecadienoic acid
13-oxo-9,11-octadecadienoic acid
13-oxo-9,11-octadecadienoic acid: found in biological membranes oxygenated by the reticulocyte lipoxygenase. 13-oxo-9,11-octadecadienoic acid : An oxooctadecadienoic acid that is 9,11-octadecadienoic acid in which the oxo group is located at position 13.. 13-oxo-9E,11E-ODE : An oxooctadecadienoic acid that consists of 9E,11E-octadecadienoic acid with the oxo substituent located at position 13.		2.934013-oxo-9,11-octadecadienoic acid;
oxo fatty acid		metabolite
9-hydroxy-10,12,15-octadecatrienoic acid
9-hydroxy-10,12,15-octadecatrienoic acid: structure given in first source; RN given refers to (S-(E,Z,Z))-isomer; cpd without isomeric designation not avail 1/90. 9(S)-HOTrE : A 9-HOTrE consisting of (10E,12Z,15Z)-octadecatrienoic acid in which the 9-hydroxy group has S-configuration.		1.97109-HOTrEplant metabolite
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		1.9910organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
cytochrome c-t
Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Ovary
[description not available]		02.1110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.1110
Dyslipidemia
[description not available]		02.0610
Dyslipidemias
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.		02.0610