Pyruvate Dehydrogenase Complex Deficiency Disease

An inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE.

Synonym
Pyruvate Dehydrogenase Complex Deficiency Disease

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	49 (31.41)	23.3326
1990's	48 (30.77)	12.5806
2000's	31 (19.87)	18.1394
2010's	22 (14.10)	28.8240
2020's	6 (3.85)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	3	0
carnitine	low	7	0
choline	low	2	0
3-hydroxybutyric acid	low	1	0
methylmalonic acid	low	1	0
creatine	low	1	0
lactic acid	medium	43	1
dihydrolipoamide	low	1	0
glycerol	low	1	0
hydrogen carbonate	low	2	0
lipoamide	low	1	0
thioctic acid	low	5	0
pyridoxine	low	1	0
pyruvic acid	low	27	0
succinic acid	low	2	0
thiamine	low	35	0
acetazolamide	low	1	0
baclofen	low	1	0
carbonyl cyanide m-chlorophenyl hydrazone	low	1	0
doxapram	low	1	0
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	low	1	0
4-phenylbutyric acid	low	1	0
vigabatrin	low	3	0
zonisamide	low	1	0
alanine	low	7	0
serine	low	1	0
aspartic acid	low	3	0
adenosine diphosphate	low	1	0
galactose	low	3	0
methylene blue	low	1	0
leucine	low	1	0
methionine	low	2	0
phenylalanine	low	2	0
valine	low	1	0
arginine	low	5	0
dichloroacetic acid	medium	19	3
thiamine pyrophosphate	low	10	0
isoxazoles	low	1	0
thiazoles	low	1	0
2,6-dichloroindophenol	low	1	0
dithiothreitol	low	1	0
fluorides	low	1	0
osmium tetroxide	low	1	0
phenyl acetate	low	6	0
glutamic acid	low	3	0
almitrine	low	1	0
adenosine	low	1	0
n-acetylaspartic acid	low	1	0
coenzyme a	low	1	0
deoxyglucose	low	1	0
proline	low	3	0
biotin	low	2	0
thiamine thiothiazolone pyrophosphate	low	1	0
leupeptins	low	1	0
glycogen	low	1	0
bradykinin	low	1	0
alpha-aminobutyric acid	low	1	0
sodium arsenite	low	1	0
acetyl coenzyme a	low	4	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
riboflavin	low	1	0
sodium bicarbonate	low	1	0
isomethyleugenol	low	2	0
D-fructopyranose	low	1	0
fursultiamin	low	1	0
linoleic acid	low	1	0
coenzyme q10	low	1	0
phosphorus	low	1	0
antimycin a	low	1	0
myxothiazol	low	1	0
etomoxir	low	1	0
arginine aspartate	low	1	0
nad	low	3	0
glucagon	low	1	0
phosphatidylcholines	low	1	0
ubiquinone	low	1	0
antimycin	low	1	0

Protein Targets (783)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Thioredoxin reductase 1, cytoplasmic	0	2	0	3
Thioredoxin reductase 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	4	0	0	4
survival motor neuron protein isoform d	7	0	0	7
Histone deacetylase 3	0	2	0	2
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	2	0	2
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	5	0	0	5
GALC protein	1	0	0	1
GLI family zinc finger 3	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	9	0	0	9
estrogen-related nuclear receptor alpha	7	0	0	7
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	4	0	0	4
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	7	0	0	7
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
geminin	7	0	0	7
peripheral myelin protein 22	4	0	0	4
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	6	1	0	7
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	1	9
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	7	0	7
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	8	1	18
Carbonic anhydrase 2	0	8	2	18
Carbonic anhydrase 2	0	3	0	3
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	4	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	1	0	2
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Androgen receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	6	1	0	7
Translocator protein	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	6	1	1	8
Gamma-aminobutyric acid receptor subunit alpha-5	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	6	1	0	7
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	7	1	11
Carbonic anhydrase 6	0	5	1	9
Gamma-aminobutyric acid receptor subunit gamma-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	6	1	0	7
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	1	5
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	6	1	0	7
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	6	1	0	7
Adenosine receptor A2a	0	2	1	4
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	5	2	11
Carbonic anhydrase	0	4	0	5
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	3
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	6	1	1	8
Gamma-aminobutyric acid receptor subunit beta-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit beta-2	6	1	1	8
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	4	1	6
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	5	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	3
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	7
GABA theta subunit	6	1	0	7
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 4	0	2	0	4
Carbonic anhydrase 15	0	4	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	5
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	6	1	0	7
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	4	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	10
N-alpha-acetyltransferase 50	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	12	0	0	12
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	4	0	0	4
estrogen nuclear receptor alpha	16	0	0	16
NPYLR7B	0	0	2	2
IDH1	3	0	0	3
Histone H2A.x	3	0	0	3
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
flap endonuclease 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Rap guanine nucleotide exchange factor 3	1	0	0	1
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	3
Glutamate receptor 2	4	2	1	7
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	2	2
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	5	0	0	5
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 11	0	0	1	1
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
USP1 protein, partial	4	0	0	4
TDP1 protein	7	0	0	7
Microtubule-associated protein tau	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
vitamin D3 receptor isoform VDRA	4	0	0	4
cytochrome P450 3A4 isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	2	0	0	2
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	3	0	0	3
DNA polymerase iota isoform a (long)	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	8	0	0	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, Ferritin light chain	4	0	0	4
lamin isoform A-delta10	10	0	0	10
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	2	0	2
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	1	5
Glutamate receptor ionotropic, NMDA 3B	0	3	1	5
Glutamate receptor ionotropic, NMDA 3A	0	3	1	5
ATAD5 protein, partial	2	0	0	2
67.9K protein	2	0	0	2
activating transcription factor 6	8	0	0	8
D(1A) dopamine receptor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Gamma-aminobutyric acid type B receptor subunit 2	0	3	1	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	3	1	4
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	2	0	0	2
PPM1D protein	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
polyprotein	2	0	0	2
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	3	0	0	3
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Aromatase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
RAR-related orphan receptor gamma	8	0	0	8
apical membrane antigen 1, AMA1	1	0	0	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, PAPAIN	1	0	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, Cruzipain	2	0	0	2
Luciferase	4	0	0	4
acetylcholinesterase	7	0	0	7
15-lipoxygenase, partial	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	5	0	0	5
farnesoid X nuclear receptor	5	0	0	5
peroxisome proliferator-activated receptor delta	6	0	0	6
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
thyroid hormone receptor beta isoform 2	7	0	0	7
histone deacetylase 9 isoform 3	2	0	0	2
heat shock protein beta-1	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Cellular tumor antigen p53	11	0	0	11
Histamine H2 receptor	2	0	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
cellular tumor antigen p53 isoform a	2	0	0	2
DNA polymerase kappa isoform 1	6	0	0	6
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	1	0	3
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Choline O-acetyltransferase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
Spike glycoprotein	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
cytochrome P450 2D6	3	0	0	3
thyroid stimulating hormone receptor	3	0	0	3
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	4	0	5
Phospholipase A-2-activating protein	0	2	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
pregnane X nuclear receptor	4	0	0	4
caspase-3	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Free fatty acid receptor 1	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Trypsin	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Dual specificity protein phosphatase 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
Free fatty acid receptor 4	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
TAR DNA-binding protein 43	2	1	0	3
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
G	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
caspase-9 isoform alpha precursor	0	1	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Albumin	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
Cruzipain	0	1	0	1
Alpha-synuclein	1	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
phosphoglycerate kinase	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Serine racemase	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Glutamate 5-kinase	0	0	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Pyridoxal kinase	0	0	0	1
Bile salt export pump	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Acetylcholinesterase	0	2	0	2
Pyruvate kinase PKM	0	0	1	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Lysine-specific demethylase 4E	0	1	0	1
Delta-aminolevulinic acid dehydratase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Cholinesterase	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Chain A, Arginase 1	0	1	0	1
endonuclease IV	1	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing]	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Pyruvate Dehydrogenase Complex Deficiency Disease

Synonyms(1)

Research

Studies (156)

Protein Targets (783)

Pyruvate Dehydrogenase Complex Deficiency Disease

Synonyms(1)

Research

Studies (156)

Drugs Studied (91)

Protein Targets (783)