linoleic-acid and Malaria--Falciparum

linoleic-acid has been researched along with Malaria--Falciparum* in 2 studies

Other Studies

2 other study(ies) available for linoleic-acid and Malaria--Falciparum

Article	Year
Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:4 Long chain polyunsaturated fatty acids derived from essential fatty acids have been shown to be toxic to Plasmodium falciparum both in vitro and in vivo. Here, we present evidence to suggest that in patients with Plasmodium falciparum malaria the levels of lipid peroxides (a marker of free radical generation) nitric oxide (a potent free radical with immunomodulatory actions), and concentrations of linoleic acid (LA) and alpha-linolenic acid (ALA) are low, whereas those of eicosapentaenoic acid (EPA) are high. The ability of the fatty acids to kill P. falciparum is dependent on their capacity to stimulate free radical generation in neutrophils and macrophages. EPA is more potent than LA in killing the parasite. In view of this, the results of the present study suggest that in patients with P. falciparum malaria the decreased levels of lipid peroxides and nitric oxide may contribute to the persistence of the infection, whereas elevated levels of EPA may be a feeble attempt to overcome this defect. Topics: alpha-Linolenic Acid; Animals; Eicosapentaenoic Acid; Fatty Acids, Essential; Free Radicals; Humans; Linoleic Acid; Lipid Peroxides; Malaria, Cerebral; Malaria, Falciparum; Nitric Oxide; Plasmodium falciparum	1999
Alterations of uninfected red blood cells in malaria. Parasitology research, 1994, Volume: 80, Issue:1 Red blood cell (RBC) negative charges and resistance to linoleic acid (LNA)-induced lysis were studied in Plasmodium yoelii-infected mice and in malaria (P. falciparum)-affected individuals. RBCs from mice infected with P. yoelii showed a progressive decrease in the net surface negative charges at 24 h after infection, reaching a minimal value on day 3, followed by a second phase that was characterised by a recovery to normal levels on day 6. Resistance to linoleic acid follows similar kinetics. These alterations preceded the appearance of parasites in the peripheral blood. A similar increase in LNA-induced lysis was observed in RBCs from malaria-affected individuals. These early membrane alterations of uninfected RBCs could be responsible for spreading of infection and RBC lysis during infection. Topics: Adult; Animals; Electrochemistry; Electrophoresis; Erythrocyte Membrane; Erythrocytes; Female; Hemolysis; Humans; In Vitro Techniques; Linoleic Acid; Linoleic Acids; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred BALB C; Middle Aged; Plasmodium yoelii	1994

Article

Year

Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria.

Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:4

Long chain polyunsaturated fatty acids derived from essential fatty acids have been shown to be toxic to Plasmodium falciparum both in vitro and in vivo. Here, we present evidence to suggest that in patients with Plasmodium falciparum malaria the levels of lipid peroxides (a marker of free radical generation) nitric oxide (a potent free radical with immunomodulatory actions), and concentrations of linoleic acid (LA) and alpha-linolenic acid (ALA) are low, whereas those of eicosapentaenoic acid (EPA) are high. The ability of the fatty acids to kill P. falciparum is dependent on their capacity to stimulate free radical generation in neutrophils and macrophages. EPA is more potent than LA in killing the parasite. In view of this, the results of the present study suggest that in patients with P. falciparum malaria the decreased levels of lipid peroxides and nitric oxide may contribute to the persistence of the infection, whereas elevated levels of EPA may be a feeble attempt to overcome this defect.

Topics: alpha-Linolenic Acid; Animals; Eicosapentaenoic Acid; Fatty Acids, Essential; Free Radicals; Humans; Linoleic Acid; Lipid Peroxides; Malaria, Cerebral; Malaria, Falciparum; Nitric Oxide; Plasmodium falciparum

1999

Alterations of uninfected red blood cells in malaria.

Parasitology research, 1994, Volume: 80, Issue:1

Red blood cell (RBC) negative charges and resistance to linoleic acid (LNA)-induced lysis were studied in Plasmodium yoelii-infected mice and in malaria (P. falciparum)-affected individuals. RBCs from mice infected with P. yoelii showed a progressive decrease in the net surface negative charges at 24 h after infection, reaching a minimal value on day 3, followed by a second phase that was characterised by a recovery to normal levels on day 6. Resistance to linoleic acid follows similar kinetics. These alterations preceded the appearance of parasites in the peripheral blood. A similar increase in LNA-induced lysis was observed in RBCs from malaria-affected individuals. These early membrane alterations of uninfected RBCs could be responsible for spreading of infection and RBC lysis during infection.

Topics: Adult; Animals; Electrochemistry; Electrophoresis; Erythrocyte Membrane; Erythrocytes; Female; Hemolysis; Humans; In Vitro Techniques; Linoleic Acid; Linoleic Acids; Malaria; Malaria, Falciparum; Male; Mice; Mice, Inbred BALB C; Middle Aged; Plasmodium yoelii

1994