linoleic-acid and Hypertension--Pulmonary

Eicosanoids are bioactive lipids that regulate systemic inflammation and exert vasoactive effects. Specific eicosanoid metabolites have previously been associated with pulmonary hypertension (PH), yet their role remains incompletely understood.. We studied 482 participants with chronic dyspnoea who underwent clinically indicated cardiopulmonary exercise testing (CPET) with invasive haemodynamic monitoring. We performed comprehensive profiling of 888 eicosanoids and eicosanoid-related metabolites using directed non-targeted mass spectrometry, and examined associations with PH (mean pulmonary arterial pressure (mPAP) >20 mmHg), PH subtypes and physiological correlates, including transpulmonary metabolite gradients.. Among 482 participants (mean±sd age 56±16 years, 62% women), 200 had rest PH. We found 48 eicosanoids and eicosanoid-related metabolites that were associated with PH. Specifically, prostaglandin (11β-dhk-PGF2α), linoleic acid (12,13-EpOME) and arachidonic acid derivatives (11,12-DiHETrE) were associated with higher odds of PH (false discovery rate q<0.05 for all). By contrast, epoxide (8(9)-EpETE), α-linolenic acid (13(. Our findings highlight the role of specific eicosanoids, including linoleic acid and epoxide derivatives, as potential regulators of inflammation in PH. Of note, physiological correlates, including transpulmonary metabolite gradients, may prioritise future studies focused on eicosanoid-related pathways as important contributors to PH pathogenesis.

Topics: Adult; Aged; Eicosanoids; Epoxy Compounds; Female; Humans; Hypertension, Pulmonary; Inflammation; Linoleic Acid; Male; Middle Aged

To study pulmonary perfusion after long term intravenous lipid-based total parenteral nutrition (TPN).. Open experimental study.. Teaching hospital, Norway.. 31 pigs.. Infusion of TPN alone, TPN + pellets, or Ringer's solution alone through central venous catheters for 7 weeks.. Haemodynamic variables during a standardised volume load, and measurement of plasma N-terminal pro-atrial natriuretic factor (ANF).. Mean pulmonary artery pressure (PAP) was 12.9 (6.1) to 20.1 (3.0) mmHg in response to the volume load in control animals compared with 15.8 (8.5) to 25.4 (5.8) (p < 0.05) mmHg in those given TPN alone and 22.8 (10.3) (p < 0.05) to 28.0 (6.4) (p < 0.05) mmHg in those given TPN and pellets. Pulmonary vascular resistance index was also increased after TPN, but the plasma N-terminal pro-ANF concentration did not increase during infusion of TPN.. Long term TPN caused moderate pulmonary hypertension, but not longstanding right-sided congestion.

Topics: Animals; Atrial Natriuretic Factor; Catheterization, Central Venous; Central Venous Pressure; Energy Intake; Fat Emulsions, Intravenous; Hypertension, Pulmonary; Linoleic Acid; Linoleic Acids; Natriuresis; Parenteral Nutrition, Total; Protein Precursors; Pulmonary Wedge Pressure; Swine; Time Factors