linoleic-acid and Carcinoma-in-Situ

Topics: Adult; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Humans; Linoleic Acid; Mitosis; Neoplasm Invasiveness; Predictive Value of Tests; Sensitivity and Specificity; Skin Neoplasms

488 women were studied to evaluate the use of the molar ratio (%MR) of octadeca-9,11-dienoic acid (18:2(9, 11] to linoleic acid (18:2(9, 12] as a new screening method for cervical cancer and pre-cancer. A combination of Papanicolaou cytology, colposcopy and %MR 18:2(9, 11)/18:2(9, 12) were employed. 86 women (17.6%) were found to have histologically proven cervical intraepithelial neoplasia (CIN). The %MR was obtained in 452 cases (92%). There was no significant difference in %MR in cervical cell scrapes from women with or without CIN. The %MR of cervical scrapes in some women with anaerobic vaginosis was significantly elevated suggesting bacterial generation of 18:2(9, 11). The %MR of 18:2(9, 11)/18:2(9, 12) is unsuitable for the diagnosis of cervical intraepithelial neoplasia.

Topics: Adult; Biomarkers, Tumor; Carcinoma in Situ; Chromatography, High Pressure Liquid; Colposcopy; Female; Humans; Isomerism; Linoleic Acid; Linoleic Acids; Precancerous Conditions; Uterine Cervical Neoplasms