Page last updated: 2024-12-07

1,3-dioctadecanoylglycerol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3-Dioctadecanoylglycerol, also known as **1,3-distearoylglycerol** or **1,3-distearin**, is a type of **triglyceride**, which is a type of fat molecule. It's specifically a **diacylglycerol**, meaning it has two fatty acid chains attached to a glycerol backbone.

Here's a breakdown:

* **Glycerol:** A three-carbon alcohol that forms the backbone of triglycerides.
* **Octadecanoic acid (stearic acid):** A saturated fatty acid with 18 carbon atoms.
* **1,3-Dioctadecanoylglycerol:** This molecule has two stearic acid molecules attached to the 1st and 3rd carbon of glycerol.

**Why is it important for research?**

1,3-Dioctadecanoylglycerol is being investigated for various applications, including:

* **Food science:** It's used as a **food additive** due to its properties like **emulsifying** and **stabilizing**.
* **Cosmetics:** It's found in some **moisturizing creams** due to its ability to form a protective barrier on the skin.
* **Pharmaceuticals:** It's being studied for its potential therapeutic benefits in **cancer research** and **neurodegenerative diseases**.
* **Biomaterials:** It's used as a **building block** in creating biocompatible materials for drug delivery and tissue engineering.

**Key research areas:**

* **Cell signaling:** 1,3-Dioctadecanoylglycerol is a potent activator of **protein kinase C (PKC)**, a key enzyme involved in cellular signaling pathways. Researchers are investigating its role in various cellular processes, including cell growth, differentiation, and apoptosis.
* **Lipid metabolism:** Studying 1,3-dioctadecanoylglycerol can help understand how the body regulates **lipid metabolism** and its implications for health conditions like obesity and diabetes.
* **Biocompatible materials:** Its biocompatibility and ability to form stable films make it a promising candidate for developing new **biodegradable materials** for drug delivery, tissue regeneration, and other biomedical applications.

Overall, 1,3-dioctadecanoylglycerol is a fascinating molecule with potential applications in various fields. It continues to be an active area of research, with ongoing investigations exploring its diverse properties and potential uses.

Cross-References

ID SourceID
PubMed CID101269
CHEMBL ID3989749
SCHEMBL ID118948
MeSH IDM0101381

Synonyms (47)

Synonym
1,3-distearoylglycerin
1,3-distearin glyceride
glycerin 1,3-distearate
stearic acid diglycerin ester
1,3-distearin
octadecanoic acid,3-propanediyl ester
stearin,3-di-
1,3-distearoylglycerol
nsc-404229
1,3-di-o-stearoylglycerol
504-40-5
glyceryl 1,3-distearate
nsc404229
glyceryl 1,3-distearate, >=99% (tlc)
distearic acid, diester with glycerol
1,3-dioctadecanoylglycerol
(2-hydroxy-3-octadecanoyloxypropyl) octadecanoate
FT-0669023
unii-73071mw2km
einecs 215-359-0
ai3-03511
73071mw2km ,
glyceryl distearate [nf]
stearin, 1,3-di-
2-hydroxypropane-1,3-diyl distearate
nsc 404229
einecs 207-992-6
unii-733qk35bci
733qk35bci ,
octadecanoic acid, 2-hydroxy-1,3-propanediyl ester
glycerol 1,3-distearate
glyceryl 1,3-distearate-d5
octadecanoic acid, 1,1'-(2-hydroxy-1,3-propanediyl) ester
SCHEMBL118948
1,3-bisstearoyloxy-2-propanol
2-hydroxy-3-(stearoyloxy)propyl stearate #
CHEMBL3989749
1-octadecanoyl-3-octadecanoyl-sn-glycerol
diacylglycerol(18:0/0:0/18:0)
1-stearoyl-3-stearoyl-sn-glycerol
dag(18:0/0:0/18:0)
dg(18:0/0:0/18:0)
FT-0669024
DTXSID60892302
1,3-distearate-glycerol
Q27266128
BP-29844
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.42 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]