linoleic-acid and sesamol

linoleic-acid has been researched along with sesamol* in 1 studies

Other Studies

1 other study(ies) available for linoleic-acid and sesamol

ArticleYear
Decreased production of interleukin-6 and prostaglandin E2 associated with inhibition of delta-5 desaturation of omega6 fatty acids in mice fed safflower oil diets supplemented with sesamol.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:6

    The differences in the immune responses in mice fed sesame oil diets and those fed sesamin may be attributed to the presence of other lignans in the non-fat portion of the oil. The fatty acid composition (mean +/- SD mol. %) of liver membrane phospholipids and the levels of endotoxin-induced prostaglandin (PG) E2, interleukin (IL)-6, IL-10, IL-12 and tumor necrosis factor (TNF)-alpha were determined in mice fed diets supplemented with 5% safflower oil (SO) in the absence or presence of 1% sesamol. The levels of dihomo-gamma-linolenic acid (20:3omega6) were markedly higher (P<0.025) in the livers from mice fed sesamol supplemented SO diets (1.6 +/- 0.1) compared to the controls (1.4 +/- 0.1). These data suggest that sesamol or its metabolite could inhibit the in vivo delta-5 desaturation of omega6 fatty acids. Further, in animals fed sesamol supplemented SO diets, the levels of PGE2 (228 +/- 41 pg/ml) were markedly lower (P<0.01) compared to those fed SO diet alone (1355 +/- 188 pg/ml). Concomitantly, the concentrations of IL-6 were also lower (P<0.01) in mice fed sesamol diet (63 +/- 11 ng/ml) compared to the controls (143 +/- 22 ng/ml). A marked reduction in the levels of PGE2 in animals fed sesamol diets suggests that sesamol or its metabolite could inhibit the activity of cyclooxygenase enzyme.

    Topics: Animals; Arachidonic Acid; Benzodioxoles; Delta-5 Fatty Acid Desaturase; Dinoprostone; Fatty Acid Desaturases; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Female; Interleukin-10; Interleukin-12; Interleukin-6; Linoleic Acid; Liver; Membranes; Mice; Mice, Inbred BALB C; Phenols; Safflower Oil; Tumor Necrosis Factor-alpha

1999