Any fatty acid with a hydroxy functional group in the alpha- or 2-position.
ChEBI ID: 10283
| Member | Definition | Role |
|---|---|---|
| 2-hydroxy-3-methylvaleric acid | A branched-chain fatty acid that is 3-methylpentanoic acid carrying a hydroxy substitutent at position 2. | 2-hydroxy-3-methylpentanoic acid |
| 2-hydroxy-9-cis-octadecenoic acid | A 2-hydroxy fatty acid that is oleic acid which carries a hydroxy group at position 2. It is an orally bioavailable synthetic hydroxylated fatty acid which modulates the lipid content of cancer cell membranes and induces cell cycle arrest and apoptosis in several cancer cell lines. | 2-hydroxyoleic acid |
| 2-hydroxyhexadecanoic acid | A 2-hydroxy fatty acid comprising a C16 straight chain carrying a hydroxy substituent at position 2. | 2-hydroxyhexadecanoic acid |
| 2-hydroxyphytanic acid | An alpha-hydroxy fatty acid formed from phytanic acid by bacterial cytochrome P450; and also formed in human peroxisomal disorders. | 2-hydroxyphytanic acid |
| 2,4-dihydroxybutyrate | A omega-hydroxy fatty acid that is butyric acid substituted by hydroxy groups at positions 2 and 4 respectively. | 2,4-dihydroxybutanoic acid |
| alpha-hydroxyisocaproic acid | A valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position; an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome. | 2-hydroxy-4-methylvaleric acid |
| alpha-hydroxymyristic acid | A long-chain fatty acid that is a derivative of myristic acid having a hydroxy substituent at C-2. | 2-hydroxymyristic acid |
| cerebronic acid | A very long-chain hydroxy fatty acid composed of lignoceric acid having a 2-hydroxy substituent. | cerebronic acid |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 20 (15.38) | 18.7374 |
| 1990's | 16 (12.31) | 18.2507 |
| 2000's | 24 (18.46) | 29.6817 |
| 2010's | 59 (45.38) | 24.3611 |
| 2020's | 11 (8.46) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (2.22%) | 5.53% |
| Reviews | 4 (2.96%) | 6.00% |
| Case Studies | 2 (1.48%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 126 (93.33%) | 84.16% |