11,14,17-eicosatrienoate

Description

## 11,14,17-Eicosatrienoate: An Important Fatty Acid for Research

**11,14,17-Eicosatrienoate** (ETA) is a polyunsaturated fatty acid (PUFA) with three double bonds located at positions 11, 14, and 17 of its 20-carbon chain. It's a relatively uncommon fatty acid, not as prevalent as its more famous cousin, **arachidonic acid (AA)**, which has four double bonds.

**Why is ETA important for research?**

* **Unique biological activity:** ETA exhibits distinct biological activity compared to AA, suggesting different signaling pathways and downstream effects. This makes it an intriguing target for studying:
* **Inflammation:** ETA has been shown to **reduce inflammation** in certain contexts, acting as an anti-inflammatory agent. This is in contrast to AA, which is known to promote inflammation.
* **Neuroprotection:** Some studies suggest ETA might be involved in **neuroprotective mechanisms** by reducing oxidative stress and neuronal damage.
* **Cardiovascular health:** Emerging research indicates that ETA might play a role in **regulating blood pressure** and potentially contribute to cardiovascular health.
* **Metabolic pathways:** Understanding the metabolism and biosynthesis of ETA is crucial for:
* **Identifying new therapeutic targets:** Identifying enzymes involved in ETA synthesis or degradation could lead to the development of drugs targeting specific pathways for treating various conditions.
* **Developing dietary interventions:** Dietary sources of ETA are relatively limited, so research on the impact of dietary interventions on ETA levels can be helpful for understanding its role in health and disease.
* **Biomarker potential:** Measuring ETA levels in biological samples (blood, tissue, etc.) could potentially serve as a biomarker for various health conditions and responses to treatments.

**Current Research Focus:**

* **Mechanism of action:** Researchers are actively investigating how ETA exerts its unique effects at the molecular level.
* **Interactions with other fatty acids:** Understanding how ETA interacts with other PUFAs like AA and DHA is essential for comprehending its overall impact on health.
* **Therapeutic applications:** Clinical studies are underway to explore the potential of ETA in treating inflammatory diseases, neurological disorders, and cardiovascular diseases.

**Overall, 11,14,17-eicosatrienoate is a promising fatty acid with distinct biological activity that warrants further research. Understanding its unique properties and mechanisms of action could lead to new insights into health and disease, paving the way for novel therapeutic approaches.**

all-cis-icosa-11,14,17-trienoic acid : An icosatrienoic acid having three cis- double bonds at positions 11, 14 and 17. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]