Nepetalactone is a naturally occurring iridoid found in catnip (Nepeta cataria) and other plants. It is known for its psychoactive effects on cats, causing a characteristic response including rubbing, rolling, and licking. The compound is thought to act as an agonist for the olfactory receptor in the cat's nose. Nepetalactone has also been studied for its potential antimicrobial, insecticidal, and anti-inflammatory properties. It is synthesized in plants through a complex series of biosynthetic steps involving the terpenoid pathway. The unique biological effects of nepetalactone make it an interesting subject of research, particularly in the areas of animal behavior, drug discovery, and natural product chemistry.'
nepetalactone: RN given for (4aS-(4aalpha,7alpha,7aalpha))-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
trans-cis-nepetalactone : A cyclopentapyran that is (4aS,7aS)-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran substituted at position 1 by an oxo group and at positions 4 and 7 by methyl groups, respectively (the 4aS,7S,7aS-diastereomer). An iridoid monoterpenoid isolated from several Nepeta plant species. It exhibits potent repellant activity against house dust mites and mosquitoes. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 92770 |
| SCHEMBL ID | 4996253 |
| MeSH ID | M0297667 |
| Synonym |
|---|
| cyclopenta[c]pyran-1(4ah)-one, 5,6,7,7a-tetrahydro-4,7-dimethyl- |
| nepetalactone |
| nepetalactone, 4aa,7a,7ab |
| 5,6,7,7a-tetrahydro-4,7-dimethyl-cyclopenta(c)pyran-1(4ah)-one |
| cyclopenta(c)pyran-1-(4ah)-one, 5,6,7,7a-tetrahydro-4,7-dimethyl- |
| md(sub 1) 84 |
| 490-10-8 |
| 4,7-dimethyl-5,6,7,7a-tetrahydro-4ah-cyclopenta[c]pyran-1-one |
| cyclopentanecarboxylic acid, 2-(2-hydroxy-1-methylvinyl)-5-methyl-, delta-lactone |
| mdi 84 |
| SCHEMBL4996253 |
| trans-cis-nepetalactone |
| cis,trans-nepetalactone |
| nepetalactone, cis-trans- |
| cyclopenta[c]pyran-1(4ah)-one, 5,6,7,7a-tetrahydro-4,7-dimethyl-, [4as-(4a.alpha.,7.alpha.,7a.alpha.)]- |
| cyclopenta[c]pyran-1(4ah)-one, 5,6,7,7a-tetrahydro-4,7.alpha.-dimethyl-, (+)- |
| trans-nepetalactone |
| cis-trans nepetalactone |
| 4,7-dimethyl-5,6,7,7a-tetrahydrocyclopenta[c]pyran-1(4ah)-one |
| DTXSID80862022 |
| STARBLD0009034 |
| PD166389 |
| AKOS040753248 |
Nepetalactone is an attractant to feline animals causing euphoric effects. It is a repellent to mosquitoes and cockroaches.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Nepetalactone is an attractant to feline animals causing euphoric effects, while it is a repellent to mosquitoes and cockroaches." | ( Density-functional theory of the catnip molecule, nepetalactone. Badshah, SL; Jehan, R, 2022) | 1.7 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (2.38) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 13 (30.95) | 29.6817 |
| 2010's | 19 (45.24) | 24.3611 |
| 2020's | 8 (19.05) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (54.22) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 45 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||