nitrous oxide and Pain, Chronic studies

Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.

Research Excerpts

Excerpt	Relevance	Reference
"Nitrous oxide (N2O) is an NMDA receptor antagonist."	6.80	Nitrous Oxide for the Treatment of Chronic Low Back Pain. ( Atim, A; Deogaonkar, A; Katyal, S; Leizman, D; Liu, J; Mekhail, N; Sarwar, S; Sessler, DI; Turan, A; You, J; Yousef, HF, 2015)
"Seventy-seven chronic pain patients referred to dental treatment with conscious sedation with nitrous oxide/oxygen had their records included in this research."	5.42	Chronic pain relief after the exposure of nitrous oxide during dental treatment: longitudinal retrospective study. ( Mattos Júnior, FM; Mattos, RV; Siqueira, JT; Siqueira, SR; Teixeira, MJ, 2015)
"Nitrous oxide (N2O) is an NMDA receptor antagonist."	2.80	Nitrous Oxide for the Treatment of Chronic Low Back Pain. ( Atim, A; Deogaonkar, A; Katyal, S; Leizman, D; Liu, J; Mekhail, N; Sarwar, S; Sessler, DI; Turan, A; You, J; Yousef, HF, 2015)
"Nitrous oxide is an antagonist at the N-methyl-D-aspartate receptor and may prevent the development of chronic postsurgical pain."	2.76	Chronic postsurgical pain after nitrous oxide anesthesia. ( Chan, MTV; Gin, T; Leslie, K; Myles, PS; Wan, ACM, 2011)
"Nitrous oxide is known to inactivate vitamin B12 via oxidation, which can precipitate a demyelinating myelopathy akin to the classical B12 deficiency syndrome, subacute combined degeneration of the spinal cord."	1.43	An unusual cause of falls in a young woman. ( Burn, D; Sleeman, I; Wiblin, L, 2016)
"Seventy-seven chronic pain patients referred to dental treatment with conscious sedation with nitrous oxide/oxygen had their records included in this research."	1.42	Chronic pain relief after the exposure of nitrous oxide during dental treatment: longitudinal retrospective study. ( Mattos Júnior, FM; Mattos, RV; Siqueira, JT; Siqueira, SR; Teixeira, MJ, 2015)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (100.00)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).[NCT00430989]	Phase 4	7,112 participants (Actual)	Interventional	2007-04-30	Completed
Evaluating the Incidence and Association Between Nitrous Oxide and Postoperative Cognitive Disorders in Anaesthesia[NCT02489097]	Phase 4	140 participants (Actual)	Interventional	2013-09-30	Terminated (stopped due to Interim analysis results showed futility)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	15
N2O Free Group (FiO2 0.3)	19

Intervention	Days (Median)
Nitrous Oxide: 70% N2O (FiO2 0.3)	6.1
N2O Free Group (FiO2 0.3)	6.1

Intervention	participants (Number)
Nitrous Oxide: 70% N2O (FiO2 0.3)	215
N2O Free Group (FiO2 0.3)	219

nitrous oxide and Pain, Chronic

Research Excerpts

Research

Studies (7)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Cardiac Arrest

Hospital Stay (Days)

Myocardial Infarction (MI)

Pulmonary Embolism

Stroke

The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.

Wound Infection

Reviews

Trials

Other Studies

Authors	Studies
Roth, JV	1
Buhre, W	1
Disma, N	1
Hendrickx, J	1
DeHert, S	1
Hollmann, MW	1
Huhn, R	1
Jakobsson, J	1
Nagele, P	1
Peyton, P	1
Vutskits, L	1
Mattos Júnior, FM	1
Mattos, RV	1
Teixeira, MJ	1
Siqueira, SR	1
Siqueira, JT	1
Turan, A	1
Sarwar, S	1
Atim, A	1
Deogaonkar, A	1
Yousef, HF	1
Katyal, S	1
Liu, J	1
You, J	1
Leizman, D	1
Mekhail, N	1
Sessler, DI	2
Chan, MT	1
Peyton, PJ	1
Myles, PS	2
Leslie, K	2
Buckley, N	1
Kasza, J	1
Paech, MJ	1
Beattie, WS	1
Forbes, A	1
Wallace, S	1
Chen, Y	1
Tian, Y	1
Wu, WK	1
Sleeman, I	1
Wiblin, L	1
Burn, D	1
Chan, MTV	1
Wan, ACM	1
Gin, T	1

Article	Year
Nitrous Oxide for the Treatment of Chronic Low Back Pain. Anesthesia and analgesia, 2015, Volume: 121, Issue:5 Topics: Aged; Aged, 80 and over; Chronic Pain; Female; Humans; Injections, Spinal; Low Back Pain; Male; Midd	2015
Chronic postsurgical pain in the Evaluation of Nitrous Oxide in the Gas Mixture for Anaesthesia (ENIGMA)-II trial. British journal of anaesthesia, 2016, Volume: 117, Issue:6 Topics: Aged; Aged, 80 and over; Anesthesia; Anesthetics, Inhalation; Chronic Pain; Female; Hong Kong; Human	2016
Chronic postsurgical pain after nitrous oxide anesthesia. Pain, 2011, Volume: 152, Issue:11 Topics: Aged; Anesthetics, Inhalation; Chronic Pain; Female; Follow-Up Studies; Humans; Male; Middle Aged; N	2011

Article	Year
Chronic Pain and the Opioid Epidemic: Are We Ignoring the Potential Benefits of Nitrous Oxide? Anesthesia and analgesia, 2018, Volume: 126, Issue:4 Topics: Analgesics, Opioid; Chronic Pain; Humans; Nitrous Oxide	2018
Chronic pain relief after the exposure of nitrous oxide during dental treatment: longitudinal retrospective study. Arquivos de neuro-psiquiatria, 2015, Volume: 73, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Chronic Pain; Conscious Sedation; Dental Ca	2015
An unusual cause of falls in a young woman. The journal of the Royal College of Physicians of Edinburgh, 2016, Volume: 46, Issue:3 Topics: Accidental Falls; Adult; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Chronic Pain; Demyelinat	2016