| Assay ID | Title | Year | Journal | Article |
|---|
| AID729695 | In vivo agonist activity at 5-HT1A receptor in Sprague-Dawley rat DA neuron assessed as increase in bursts at 1 mg/kg, iv in presence of WAY100635 | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729709 | Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1432570 | Displacement of [3H]N-methylspiperone from human dopamine D3 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID729708 | Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID335151 | Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected type A+ human erythrocytes by [3H]hypoxanthine uptake | 1993 | Journal of natural products, Sep, Volume: 56, Issue:9
| Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. |
| AID1498687 | Inhibition of recombinant human MAO-A assessed as residual activity at 20 uM using kynuramine as substrate incubated for 20 mins by spectrophotometric method relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
| AID1432572 | Displacement of [3H]SCH23390 from human dopamine D5 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID729696 | In vivo agonist activity at 5-HT1A receptor in Sprague-Dawley rat DA neuron assessed as increase in firing rate at 1 mg/kg, iv in presence of WAY100635 | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1432571 | Displacement of [3H]N-methylspiperone from human dopamine D4 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID1498690 | Inhibition of recombinant human MAO-B using benzylamine as substrate incubated for 30 mins by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
| AID729698 | In vivo agonist activity at 5-HT1A receptor in Sprague-Dawley rat DA neuron assessed as increase in firing rate at 1 mg/kg, iv | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729692 | Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1498689 | Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 20 mins by spectrophotometric method | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
| AID729697 | In vivo agonist activity at 5-HT1A receptor in Sprague-Dawley rat DA neuron assessed as increase in bursts at 1 mg/kg, iv | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729707 | Antipsychotic activity in ip dosed Sprague-Dawley rat schizophrenia model assessed as inhibition of PCP-induced hyperlocomotion administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729704 | Antipsychotic activity in Sprague-Dawley rat schizophrenia model assessed as inhibition of PCP-induced prepulse inhibition at 5 mg/kg, ip administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729714 | Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729693 | In vivo agonist activity at 5-HT1A receptor in WAY100635 pre-treated Sprague-Dawley rat DA neuron assessed as increase in bursts at 1 mg/kg, iv | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729715 | Inhibition of [3H]Ketanserin binding to 5-HT2A receptor (unknown origin) expressed in HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID335152 | Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum W2 infected type A+ human erythrocytes by [3H]hypoxanthine uptake | 1993 | Journal of natural products, Sep, Volume: 56, Issue:9
| Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. |
| AID1432569 | Displacement of [3H]N-methylspiperone from human dopamine D2 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID724169 | Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs | 2013 | Bioorganic & medicinal chemistry, Jan-01, Volume: 21, Issue:1
| Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity. |
| AID729717 | Inhibition of [3H]spiperone binding to dopamine D2 receptor (unknown origin) expressed in human HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729712 | Displacement of [3H]8-OH-DPAT from 5-HT1A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1432568 | Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr | 2017 | Bioorganic & medicinal chemistry letters, 03-15, Volume: 27, Issue:6
| Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors. |
| AID729718 | Inhibition of [3H]SCH23390 binding to dopamine D1 receptor (unknown origin) expressed in human HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729700 | Effect on baseline startle reactivity in Sprague-Dawley rat schizophrenia model at 5 mg/kg, ip administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID1498688 | Inhibition of recombinant human MAO-B assessed as residual activity at 20 uM using benzylamine as substrate incubated for 30 mins by spectrophotometric method relative to control | 2018 | Bioorganic & medicinal chemistry letters, 08-01, Volume: 28, Issue:14
| Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid. |
| AID729701 | Antipsychotic activity in Sprague-Dawley rat schizophrenia model assessed as effect on 120 db noise-induced absolute acoustic startle responses at 5 mg/kg, ip administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729713 | Displacement of [3H]spiperone from dopamine D2 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729710 | Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729694 | In vivo agonist activity at 5-HT1A receptor in WAY100635 pre-treated Sprague-Dawley rat DA neuron assessed as increase in firing rate at 1 mg/kg, iv | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729716 | Inhibition of [3H]8-OH-DPAT binding to 5-HT1A receptor (unknown origin) expressed in HEK293 cells at 10 uM by liquid scintillation counter relative to control | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729711 | Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) expressed in HEK293 cells by liquid scintillation counter | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID335154 | Selectivity index, ED50 for human KB cells to ED50 for chloroquine-resistant Plasmodium falciparum W2 | 1993 | Journal of natural products, Sep, Volume: 56, Issue:9
| Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. |
| AID335153 | Selectivity index, ED50 for human KB cells to ED50 for chloroquine-sensitive Plasmodium falciparum D6 | 1993 | Journal of natural products, Sep, Volume: 56, Issue:9
| Cytotoxic and antimalarial alkaloids from the tubers of Stephania pierrei. |
| AID729699 | Effect on prepulse inhibition in Sprague-Dawley rat schizophrenia model at 5 mg/kg, ip administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| AID729706 | Antipsychotic activity in Sprague-Dawley rat schizophrenia model assessed as inhibition of PCP-induced hyperlocomotion at 2.5 mg/kg, ip administered 10 mins prior testing monitored for 5 mins | 2013 | Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
| Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |