naltrexone has been researched along with Pain, Chronic in 59 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 37 (62.71) | 24.3611 |
2020's | 22 (37.29) | 2.80 |
Authors | Studies |
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Araya, EI; Baggio, DF; Barroso, AR; Chichorro, JG; Koren, LO; Turnes, JM; Zanoveli, JM | 1 |
Israel, RJ; Mehta, N; Slatkin, NE; Stambler, N | 1 |
Agarwal, A; Gautam, S; Khuba, S; Kumar, S; Shamshrey, C; Singh, A | 1 |
Akbik, H; Atluri, S; Buenaventura, R; Dann, T; Ferguson, K; Italiano, J; Sachdeva, H; Soin, A; Soin, Y; Sudarshan, G | 2 |
Choo, TH; Langleben, DD; Nunes, EV; Pavlicova, M; Rotrosen, J; Shulman, M; Wang, AL | 1 |
Brenner, D; Israel, RJ; Slatkin, NE; Stambler, N; Webster, LR | 1 |
Di Cerbo, A; Iannitti, T; Morales-Medina, JC; Pugliese, N; Zizzadoro, C | 1 |
Aitcheson, N; Lin, Z; Tynan, K | 1 |
Bacorro, E; Beaudette-Zlatanova, B; Branch-Elliman, W; Dubreuil, M; Eyvazzadeh, C; Kaur, M; Lazzari, AA; Lew, RA; Libbey, C; Monach, PA; Otis, JD | 1 |
Chadwick, AL; Rupp, A; Young, E | 1 |
Creech, ZA; Koushik, SS; Noss, B; Poliwoda, S; Truong, GTD; Urits, I; Viswanath, O | 1 |
Bass, A; Pixton, GC; Rauck, RL; Wilson, JG; Wolfram, G | 1 |
Hu, C; Luo, Z; Miao, J; Shen, Y; Shu, S; Wang, Y; Zhu, X | 1 |
Hale, M; Webster, L; Wild, J; Yamada, T | 1 |
Brenner, DM; Liu, JJ; Quinton, SE | 1 |
Fishman, MA; Kim, PS | 1 |
Ashman, L; Hatfield, E; Phillips, K; Swidan, S | 1 |
Bendiks, S; Blokhina, E; Bryant, K; Cheng, DM; Gnatienko, N; Krupitsky, E; Samet, JH; Tsui, JI; Verbitskaya, E; Vetrova, M | 1 |
Freeman, PR; Huang, Z; Oser, C; Sohn, M; Talbert, JC | 1 |
Kim, SA; Kim, YJ; Lee, GJ; Oh, SB | 1 |
Amaya, F; Ishikawa, T; Kanbayashi, Y; Tabuchi, Y; Taguchi, T; Takayama, K; Ueno, H | 1 |
Wirz, S | 1 |
Arjona Ferreira, JC; Webster, LR; Yamada, T | 1 |
Markham, A | 1 |
Arjona Ferreira, JC; Hale, M; Reddy, J; Wild, J; Yamada, T | 1 |
Harper, JR; Israel, RJ; Khan, A; Michna, E; Webster, LR | 1 |
Murphy, JA; Sheridan, EA | 1 |
Berlau, DJ; Patten, DK; Schultz, BG | 1 |
Arjona Ferreira, JC; Baba, Y; Morlion, B; Nalamachu, S; Reddy, J; Webster, LR; Yamada, T | 1 |
Abdollahi, M; Mozaffari, S; Nikfar, S | 1 |
Fukumura, K; Kubota, R; Wajima, T | 1 |
Pixton, GC; Setnik, B; Sommerville, KW; Webster, L | 1 |
Fanelli, A; Ghisi, D; Sorella, MC | 1 |
Donahue, RR; Doolen, S; Grachen, CM; Morón, JA; Sinha, GP; Taylor, BK | 1 |
Hein, M; Ji, G; Navratilova, E; Neugebauer, V; Phelps, C; Porreca, F; Qu, C; Yakhnitsa, V | 1 |
Faraone, S; Johnson, B; Middleton, B; Oaks, Z; Stage, A | 1 |
Benth, JŠ; Krajci, P; Kunoe, N; Latif, ZE; Opheim, A; Sharma-Haase, K; Solli, KK; Tanum, L | 1 |
Bannister, K; Dickenson, AH; Navratilova, E; Phelps, CE; Porreca, F | 1 |
Baumrucker, SJ; Trofimovitch, D | 1 |
Arjona Ferreira, JC; Hale, M; Wild, J; Yamada, T | 1 |
Blair, HA | 1 |
Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK | 1 |
Bilsky, EJ; Cain, JP; Hruby, VJ; Hu, J; Kumirov, VK; Lee, YS; Podolsky, AT; Sandweiss, A; Vanderah, TW; Vardanyan, RS | 1 |
McLain, D; Parkitny, L; Younger, J | 1 |
Atayee, RS; Best, BM; Liu, JC; Ma, JD; Morello, CM | 1 |
Bansal, D; Ghai, B; Hota, D; Shah, CS | 1 |
Thompson, CA | 1 |
Beaudry, H; Gendron, L; Morón, JA | 1 |
Indovina, P; Raffaeli, W | 1 |
Frohe, T; Kirouac, M; Maisto, SA; McCallion, E; Vowles, KE; Witkiewitz, K | 1 |
Bass, A; Bramson, C; Hale, ME; Malhotra, BK; Meisner, P; Pixton, G; Rauck, RL; Setnik, B; Sommerville, KW; Wilson, JG; Wolfram, G | 1 |
Weber, HC | 1 |
Baqai, A; Diwan, S; Giambrone, GP; Mehta, N; O'Connell, K | 1 |
Davis, MP | 1 |
Harper, JR; Israel, RJ; Rauck, R; Slatkin, NE; Stambler, N | 1 |
Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D | 1 |
Lee, JM; Mooney, J | 1 |
Pappagallo, M; Sokolowska, M | 1 |
18 review(s) available for naltrexone and Pain, Chronic
Article | Year |
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Reductions in All-Cause Mortality Associated with the Use of Methylnaltrexone for Opioid-Induced Bowel Disorders: A Pooled Analysis.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Narcotic Antagonists; Randomized Controlled Trials as Topic; Retrospective Studies | 2023 |
Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis.
Topics: Chronic Pain; Fibromyalgia; Humans; Naltrexone; Prospective Studies | 2023 |
Low-dose naltrexone's utility for non-cancer centralized pain conditions: a scoping review.
Topics: Chronic Disease; Chronic Pain; Humans; Inflammation; Naltrexone; Quality of Life | 2023 |
Naldemedine for the treatment of opioid-induced constipation in adults with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Opioid-Induced Constipation | 2020 |
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review.
Topics: Chronic Pain; Fibromyalgia; Humans; Multiple Sclerosis; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders | 2020 |
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review.
Topics: Chronic Pain; Fibromyalgia; Humans; Naltrexone; Pain Management; Quality of Life | 2020 |
Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review.
Topics: Animals; Chronic Pain; Fibromyalgia; Humans; Naltrexone; Prospective Studies; Retrospective Studies; United States | 2021 |
[Management of adverse effects of opioid therapy].
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Chronic Pain; Constipation; Drug-Related Side Effects and Adverse Reactions; Germany; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Treatment Outcome | 2017 |
Evidence Based Review of Pharmacotherapy for Opioid-Induced Constipation in Noncancer Pain.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Evidence-Based Practice; Humans; Laxatives; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Piperidines; Polyethylene Glycols; Quaternary Ammonium Compounds; Randomized Controlled Trials as Topic | 2018 |
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders.
Topics: Animals; Anti-Inflammatory Agents; Chronic Pain; Crohn Disease; Dose-Response Relationship, Drug; Fibromyalgia; Humans; Inflammation; Multiple Sclerosis; Naltrexone; Narcotic Antagonists; Quality of Life | 2018 |
Methylnaltrexone bromide for the treatment of opioid-induced constipation.
Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Government Regulation; Half-Life; Humans; Naltrexone; Quality of Life; Quaternary Ammonium Compounds; Treatment Outcome | 2018 |
Morphine sulfate abuse-deterrent formulations for the treatment of chronic pain.
Topics: Abuse-Deterrent Formulations; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Humans; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prescription Drug Misuse | 2018 |
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes.
Topics: Analgesics, Non-Narcotic; Cancer Pain; Chronic Pain; Complex Regional Pain Syndromes; Diabetic Neuropathies; Dose-Response Relationship, Drug; Fibromyalgia; Humans; Naltrexone; Pain Management; Palliative Care; Quality of Life | 2019 |
Naldemedine: A Review in Opioid-Induced Constipation.
Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Clinical Trials, Phase III as Topic; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quality of Life | 2019 |
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.
Topics: Anti-Inflammatory Agents; Chronic Pain; Fibromyalgia; Humans; Naltrexone; Neuroglia | 2014 |
Opioid-induced constipation in chronic noncancer pain.
Topics: Analgesics, Opioid; Chloride Channel Agonists; Chronic Pain; Constipation; Humans; Lubiprostone; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; Receptors, Opioid, mu | 2016 |
Efficacy of methylnaltrexone for the treatment of opiod-induced constipation: a meta-analysis and systematic review.
Topics: Analgesics, Opioid; Chronic Pain; Constipation; Humans; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2016 |
Pharmacokinetic and pharmacodynamic evaluation of oxycodone and naltrexone for the treatment of chronic lower back pain.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Humans; Low Back Pain; Naltrexone; Opioid-Related Disorders; Oxycodone; Practice Guidelines as Topic | 2016 |
14 trial(s) available for naltrexone and Pain, Chronic
Article | Year |
---|---|
Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Humans; Naltrexone; Opioid-Induced Constipation; Quaternary Ammonium Compounds; Treatment Outcome | 2021 |
Baseline- and treatment-associated pain in the X:BOT comparative effectiveness study of extended-release naltrexone versus buprenorphine-naloxone for OUD.
Topics: Buprenorphine, Naloxone Drug Combination; Chronic Pain; Delayed-Action Preparations; Humans; Injections, Intramuscular; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Prospective Studies | 2022 |
Pilot Study of Low-dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: A Randomized, Double-blind, Placebo-controlled, Crossover Clinical Trial.
Topics: Arthritis; Chronic Pain; Double-Blind Method; Fatigue; Humans; Naltrexone; Peripheral Nervous System Diseases; Pilot Projects; Quality of Life; Treatment Outcome | 2023 |
Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Cross-Over Studies; Delayed-Action Preparations; Fasting; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Oxycodone; Tablets; Therapeutic Equivalency | 2020 |
Pilot study of tolerability and safety of opioid receptor antagonists as novel therapies for chronic pain among persons living with HIV with past year heavy drinking: a randomized controlled trial.
Topics: Alcoholism; Chronic Pain; HIV Infections; Humans; Naltrexone; Narcotic Antagonists; Pilot Projects; Treatment Outcome | 2023 |
A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists | 2017 |
Naldemedine versus placebo for opioid-induced constipation (COMPOSE-1 and COMPOSE-2): two multicentre, phase 3, double-blind, randomised, parallel-group trials.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Constipation; Defecation; Double-Blind Method; Drug Administration Schedule; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Receptors, Opioid, mu; Young Adult | 2017 |
Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Time | 2017 |
Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quality of Life; Treatment Outcome | 2018 |
No increased pain among opioid-dependent individuals treated with extended-release naltrexone or buprenorphine-naloxone: A 3-month randomized study and 9-month open-treatment follow-up study.
Topics: Adult; Buprenorphine, Naloxone Drug Combination; Chronic Pain; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Norway; Opiate Substitution Treatment; Opioid-Related Disorders; Pain Measurement | 2019 |
Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Time Factors; Treatment Outcome | 2019 |
Pain as a predictor of heavy drinking and any drinking lapses in the COMBINE study and the UK Alcohol Treatment Trial.
Topics: Acamprosate; Adult; Alcohol Deterrents; Alcohol Drinking; Alcohol-Related Disorders; Behavior Therapy; Chronic Pain; Combined Modality Therapy; Female; Humans; Male; Naltrexone; Pain Measurement; Recurrence; Taurine; Treatment Outcome | 2015 |
A randomized double-blind, placebo-controlled efficacy and safety study of ALO-02 (extended-release oxycodone surrounding sequestered naltrexone) for moderate-to-severe chronic low back pain treatment.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Analysis of Variance; Chronic Pain; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Humans; Low Back Pain; Middle Aged; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Treatment Outcome; Young Adult | 2015 |
Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Pain; Constipation; Double-Blind Method; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Treatment Outcome | 2017 |
27 other study(ies) available for naltrexone and Pain, Chronic
Article | Year |
---|---|
Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trigeminal Neuralgia | 2022 |
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review".
Topics: Chronic Pain; Humans; Naltrexone | 2021 |
In Response Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review".
Topics: Chronic Pain; Humans; Naltrexone | 2021 |
Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Inverse Agonism; Hyperalgesia; Inflammation; Mice; Naltrexone; Opioid Peptides; Opioid-Related Disorders; Rats; Rats, Wistar | 2023 |
The Utilization of Low Dose Naltrexone for Chronic Pain.
Topics: Analgesics, Opioid; Chronic Disease; Chronic Pain; Humans; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Recurrence | 2023 |
Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride) extended-release capsules in older patients: a pooled analysis of two clinical trials.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Double-Blind Method; Drug Combinations; Female; Humans; Low Back Pain; Male; Middle Aged; Naltrexone; Oxycodone; Randomized Controlled Trials as Topic; Young Adult | 2020 |
Safety and Efficacy of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Non-Cancer Pain Receiving Opioid Therapy: A Subgroup Analysis of Patients ≥ 65 Years of Age.
Topics: Aged; Aged, 80 and over; Chronic Pain; Female; Humans; Male; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Safety | 2020 |
Trends in Urine Drug Monitoring Among Persons Receiving Long-Term Opioids and Persons with Opioid Use Disorder in the United States.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Chronic Pain; Cross-Sectional Studies; Drug Monitoring; Female; Humans; Male; Methadone; Middle Aged; Naltrexone; Opioid-Related Disorders; United States; Young Adult | 2021 |
Naloxone-induced analgesia mediated by central kappa opioid system in chronic inflammatory pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Microinjections; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid, kappa | 2021 |
Factors affecting the effect of naldemedine for opioid-induced constipation: a single-institution, retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cholinergic Antagonists; Chronic Pain; Female; Humans; Male; Middle Aged; Naltrexone; Narcotic Antagonists; Opioid-Induced Constipation; Retrospective Studies; Time Factors; Tramadol; Treatment Outcome; Young Adult | 2021 |
Naldemedine: First Global Approval.
Topics: Analgesics, Opioid; Chronic Pain; Clinical Trials as Topic; Constipation; Drug Approval; Humans; Japan; Laxatives; Naltrexone; United States | 2017 |
Population Pharmacokinetics and Exposure-Response Relationships of Naldemedine.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Body Weight; Cancer Pain; Chronic Pain; Constipation; Creatinine; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Models, Biological; Naltrexone | 2018 |
Extended-release morphine sulfate and naltrexone hydrochloride (EMBEDA): naltrexone-associated withdrawal and abuse-related effects in patients with chronic pain and recreational opioid users.
Topics: Adult; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Female; Humans; Male; Middle Aged; Morphine; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2019 |
Opioid receptors inhibit the spinal AMPA receptor Ca
Topics: Adamantane; Animals; Calcium; Chronic Pain; Excitatory Postsynaptic Potentials; Freund's Adjuvant; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Nociception; Posterior Horn Cells; Receptors, AMPA; Receptors, Glutamate; Receptors, Opioid; Spinal Cord; Synapses | 2019 |
Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.
Topics: Animals; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neuralgia; Neurons; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Synaptic Transmission | 2019 |
Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Female; Fibromyalgia; Humans; Hyperalgesia; Male; Middle Aged; Naltrexone; Opioid-Related Disorders; Pain Management; Pain Measurement; Pain Threshold; Predictive Value of Tests; Retrospective Studies; Young Adult | 2018 |
Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain.
Topics: Amygdala; Animals; Chronic Pain; Diffuse Noxious Inhibitory Control; Electrophysiological Phenomena; Functional Laterality; Hindlimb; Hyperalgesia; Ligation; Male; Naltrexone; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Spinal Nerves | 2019 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Isoflurane; Male; Mice; Naltrexone; Nociceptive Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enkephalins; Fentanyl; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Naltrexone metabolism and concomitant drug concentrations in chronic pain patients.
Topics: Age Factors; Analgesics, Opioid; Chronic Pain; Creatinine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Humans; Limit of Detection; Male; Medication Adherence; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Retrospective Studies; Sex Factors | 2014 |
Off-label, low-dose naltrexone for refractory chronic low back pain.
Topics: Adult; Chronic Pain; Humans; Low Back Pain; Male; Naltrexone; Narcotic Antagonists; Off-Label Use; Pain Measurement; Treatment Outcome | 2014 |
GI relief may come sooner than later for patients with chronic noncancer pain.
Topics: Adult; Analgesics, Opioid; Chronic Pain; Constipation; Drug Approval; Humans; Morphinans; Naltrexone; Narcotic Antagonists; Polyethylene Glycols; Quaternary Ammonium Compounds; United States; United States Food and Drug Administration | 2014 |
Implication of delta opioid receptor subtype 2 but not delta opioid receptor subtype 1 in the development of morphine analgesic tolerance in a rat model of chronic inflammatory pain.
Topics: Analgesics, Opioid; Animals; Benzylidene Compounds; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Freund's Adjuvant; Hindlimb; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats, Sprague-Dawley; Receptors, Opioid, delta | 2015 |
Low-dose naltrexone to prevent intolerable morphine adverse events: a forgotten remedy for a neglected, global clinical need.
Topics: Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Humans; Morphine; Naltrexone; Narcotic Antagonists; Neoplasms | 2015 |
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord | 2017 |
Methylnaltrexone in treatment of opioid-induced constipation in a pediatric patient.
Topics: Analgesics, Opioid; Child, Preschool; Chronic Pain; Constipation; Humans; Male; Naltrexone; Narcotic Antagonists; Pediatrics; Quaternary Ammonium Compounds | 2012 |
The implications of tamper-resistant formulations for opioid rotation.
Topics: Analgesics, Opioid; Chronic Pain; Delayed-Action Preparations; Drug Combinations; Drug Compounding; Drug Tolerance; Humans; Morphine; Naltrexone; Opioid-Related Disorders; Oxycodone; Oxymorphone; Patient Selection | 2012 |