glutamic acid and Pain, Chronic

glutamic acid has been researched along with Pain, Chronic in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's24 (61.54)24.3611
2020's15 (38.46)2.80

Authors

AuthorsStudies
Du, X; Gamper, N; Huang, D; Ma, J; Niu, C; Sun, H; Wang, J; Zhang, H; Zhang, L; Zhang, Y; Zhu, T1
Ackermann, PW; Alim, MA; Pejler, G; Peterson, M1
de Chastelain, A; DeMayo, MM; Harris, AD; McPeak, A; Miller, JV; Noel, M; Pigott, T; Rasic, N; Rayner, L1
Goyette, MJ; Holton, K; Murray, SL; Saldanha, CJ1
Luo, C; Wu, SX; Xie, RG; Xu, GY1
Jin, Y; Li, J; Li, X; Luo, MH; Mao, Y; Mei, L; Meng, Q; Tao, W; Wang, H; Xie, W; Zhang, X; Zhang, Z; Zhou, W; Zhu, X1
Cai, YQ; Hou, YY; Pan, ZZ1
Barry, D; Drago, T; Gallagher, H; King, R; Levins, KJ; Martin, A; Murphy, P; O'Hanlon, E; Roddy, DW; Roman, E1
Aguila, MR; Leaver, AM; Peek, AL; Puts, NA; Rebbeck, T; Watson, J1
Legarreta, MD; McGlade, EC; Prescot, AP; Renshaw, PF; Sheth, C; Yurgelun-Todd, DA1
Chen, C; Jin, Y; Li, J; Li, X; Mao, Y; Pan, ZZ; Tang, ZQ; Tao, W; Wang, H; Wang, L; Wang, Y; Xie, W; Zhang, X; Zhang, Z; Zhou, C; Zhou, W1
Fifi, AC; Holton, KF1
Baraniuk, JN; Baron, M; Brandley, ET; Holton, KF; Kirkland, AE; Langan, MT; Ramachandra, SS1
Aubrey, KR; Balle, T; Otsu, Y; Sheipouri, D; Vandenberg, RJ1
Andronesi, OC; Berry, MP; Edwards, RR; Ellingsen, DM; Grahl, A; Isaro, L; Lazaridou, A; Lee, J; Loggia, ML; Napadow, V; Paschali, M; Ratai, EM; Torrado-Carvajal, A; Wasan, AD; Weerasekera, A1
Alam, M; Gustin, SM; Hesam-Shariati, N; Kang, D; McAuley, JH; Rae, CD; Trost, Z1
Bjerrum, OJ; Gegelashvili, G2
Chu, MK; Kim, J; Lee, HS; Nam, JH1
Chen, YY; Fei, S; Miao, B; Su, Z; Xu, MQ; Zhang, J; Zhen, LL1
Zhuo, M3
Clauw, DJ; Harris, RE; Harte, SE; Ichesco, E; Kaplan, CM; Kochlefl, L; Larkin, TE; Mashour, GA; Mawla, I; Schrepf, A; Vatansever, D1
Andoh, T; Doi, A; Kato, G; Koga, K; Kume, T; Uta, D; Yoshimura, M1
Narita, M; Suzuki, T; Yoshizawa, K1
Forsberg, F; Gerdle, B; Ghafouri, B; Ghafouri, N; Karlsson, L; Larsson, B; Stensson, N1
Clauw, DJ; Foerster, B; Hampson, J; Harris, RE; Huggins, JP; Kim, J; Napadow, V; Pauer, L; Petrou, M; Schmidt-Wilcke, T; Sundgren, PC1
Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR1
Baker, G; Benson, C; Dursun, S; Jesudasan, SJ; Kerr, B; Mifflin, K1
As-Sanie, S; Clauw, DJ; Harris, RE; Kim, J; Napadow, V; Schmidt-Wilcke, T; Sundgren, PC1
González-Sepúlveda, M; Marcos, J; Pozo, OJ; Valverde, O1
Chen, L; Mao, J; McCabe, MF; Mi, W; Shen, S; Sun, Y; Wang, S; Yang, J; Yang, L; You, Z; Zhang, S1
Bacci, A; Feraco, P; Leonardi, M; Malavolta, N; Passamonti, L; Pedrabissi, F; Zampogna, G1
Alexander, R; Kanes, S; Lee, CM; McCarthy, DJ; Pathak, S; Sanacora, G; Smith, MA1
Clauw, DJ; Harris, RE1
Tao, YX1
Babaniyi, OB; Barrett, LB; Bartels, K; Inquimbert, P; Scholz, J; Tegeder, I1
Baggio, CH; Carbonero, ER; Córdova, MM; Iacomini, M; Martins, DF; Ruthes, AC; Santos, AR; Silva, MD1

Reviews

13 review(s) available for glutamic acid and Pain, Chronic

ArticleYear
Tendon pain - what are the mechanisms behind it?
    Scandinavian journal of pain, 2023, 01-27, Volume: 23, Issue:1

    Topics: Chronic Disease; Chronic Pain; Glutamic Acid; Humans; Nerve Fibers; Tendinopathy; Tendons

2023
Sex Hormones, Neurosteroids, and Glutamatergic Neurotransmission: A Review of the Literature.
    Neuroendocrinology, 2023, Volume: 113, Issue:9

    Topics: Chronic Pain; Epilepsy; Estrogens; Glutamic Acid; Gonadal Steroid Hormones; Humans; Neurosteroids

2023
Presynaptic glutamate receptors in nociception.
    Pharmacology & therapeutics, 2023, Volume: 251

    Topics: Chronic Pain; Glutamic Acid; Humans; Inflammation; Neurotransmitter Agents; Nociception; Receptors, Glutamate; Receptors, Presynaptic

2023
Brain GABA and glutamate levels across pain conditions: A systematic literature review and meta-analysis of 1H-MRS studies using the MRS-Q quality assessment tool.
    NeuroImage, 2020, 04-15, Volume: 210

    Topics: Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Migraine Disorders; Musculoskeletal Pain; Proton Magnetic Resonance Spectroscopy

2020
Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology.
    Advances in neurobiology, 2017, Volume: 16

    Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Chronic Pain; Glutamic Acid; Humans; Neurons; Spinal Cord

2017
Long-term cortical synaptic changes contribute to chronic pain and emotional disorders.
    Neuroscience letters, 2019, 05-29, Volume: 702

    Topics: Adenylyl Cyclases; Animals; Brain; Chronic Pain; Emotions; Enzyme Activation; Genes, Immediate-Early; Glutamic Acid; Humans; Mental Disorders; Neuronal Plasticity; Phosphorylation; Protein Biosynthesis; Receptors, Cell Surface; Synapses

2019
Psychological dependence on opioid analgesics.
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2013, Volume: 142, Issue:1

    Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Utilization; Glutamic Acid; Humans; Japan; Morphine Dependence; Opioid-Related Disorders; Signal Transduction

2013
Long-term potentiation in the anterior cingulate cortex and chronic pain.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014, Jan-05, Volume: 369, Issue:1633

    Topics: Chronic Pain; Glutamic Acid; Gyrus Cinguli; Humans; Long-Term Potentiation; Models, Neurological; Pain Perception; Receptors, AMPA

2014
High-affinity glutamate transporters in chronic pain: an emerging therapeutic target.
    Journal of neurochemistry, 2014, Volume: 131, Issue:6

    Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Chronic Pain; Glutamic Acid; Humans; Neurons; Spinal Cord

2014
Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression.
    Modern trends in pharmacopsychiatry, 2015, Volume: 30

    Topics: Biogenic Amines; Chronic Pain; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans

2015
Ionotropic glutamate receptors contribute to pain transmission and chronic pain.
    Neuropharmacology, 2017, Volume: 112, Issue:Pt A

    Topics: Animals; Cerebral Cortex; Chronic Pain; Glutamic Acid; Gyrus Cinguli; Humans; Long-Term Potentiation; Pruritus; Receptors, AMPA; Receptors, Ionotropic Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spinal Cord Dorsal Horn; Synaptic Transmission

2017
Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.
    Neuroscience letters, 2012, Jun-29, Volume: 520, Issue:2

    Topics: Analgesics; Brain; Chronic Pain; Drug Discovery; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Neuroimaging; Precision Medicine

2012
AMPA receptor trafficking in inflammation-induced dorsal horn central sensitization.
    Neuroscience bulletin, 2012, Volume: 28, Issue:2

    Topics: Animals; Chronic Pain; Glutamic Acid; Humans; Inflammation; Neuronal Plasticity; Nociceptors; Posterior Horn Cells; Protein Transport; Receptors, AMPA; Synaptic Transmission

2012

Trials

3 trial(s) available for glutamic acid and Pain, Chronic

ArticleYear
The Low Glutamate Diet Effectively Improves Pain and Other Symptoms of Gulf War Illness.
    Nutrients, 2020, Aug-26, Volume: 12, Issue:9

    Topics: Biomarkers; Chronic Pain; Cross-Over Studies; Diet; Double-Blind Method; Female; Glutamic Acid; Humans; Male; Middle Aged; Persian Gulf Syndrome; Treatment Outcome; Veterans

2020
Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.
    Anesthesiology, 2013, Volume: 119, Issue:6

    Topics: Adolescent; Adult; Aged; Analgesics; Brain Chemistry; Chronic Pain; Cross-Over Studies; Double-Blind Method; Female; Fibromyalgia; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Middle Aged; Neural Pathways; Pain Measurement; Pregabalin; Young Adult

2013
Metabolic abnormalities in pain-processing regions of patients with fibromyalgia: a 3T MR spectroscopy study.
    AJNR. American journal of neuroradiology, 2011, Volume: 32, Issue:9

    Topics: Adult; Aspartic Acid; Choline; Chronic Pain; Creatinine; Dipeptides; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prefrontal Cortex; Thalamus

2011

Other Studies

23 other study(ies) available for glutamic acid and Pain, Chronic

ArticleYear
Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice.
    Cell reports, 2021, 11-02, Volume: 37, Issue:5

    Topics: Action Potentials; Animals; Behavior, Animal; Chronic Pain; Depression; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Female; Glutamic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways; Parabrachial Nucleus; Trigeminal Caudal Nucleus; Trigeminal Neuralgia; Ventral Tegmental Area; Vesicular Glutamate Transport Protein 2

2021
Changes in Brain GABA and Glutamate and Improvements in Physical Functioning Following Intensive Pain Rehabilitation in Youth With Chronic Pain.
    The journal of pain, 2023, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Brain; Chronic Pain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans

2023
A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain.
    Pain, 2020, Volume: 161, Issue:2

    Topics: Adjuvants, Immunologic; Animals; Anxiety; Behavior, Animal; Chronic Pain; Disease Models, Animal; Elevated Plus Maze Test; Freund's Adjuvant; GABAergic Neurons; Glutamic Acid; Inflammation; Male; Mice; Neostriatum; Neural Pathways; Neurons; Open Field Test; Optogenetics; Patch-Clamp Techniques; Somatosensory Cortex

2020
GluA1 in Central Amygdala Promotes Opioid Use and Reverses Inhibitory Effect of Pain.
    Neuroscience, 2020, 02-01, Volume: 426

    Topics: Analgesics, Opioid; Animals; Central Amygdaloid Nucleus; Chronic Pain; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Reward; Up-Regulation

2020
Magnetic resonance spectroscopy across chronic pain disorders: a systematic review protocol synthesising anatomical and metabolite findings in chronic pain patients.
    Systematic reviews, 2019, 12-27, Volume: 8, Issue:1

    Topics: Aspartic Acid; Brain; Chronic Pain; Creatine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Proton Magnetic Resonance Spectroscopy; Systematic Reviews as Topic

2019
An exploratory proton MRS examination of gamma-aminobutyric acid, glutamate, and glutamine and their relationship to affective aspects of chronic pain.
    Neuroscience research, 2021, Volume: 163

    Topics: Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Protons

2021
MeCP2 mediates transgenerational transmission of chronic pain.
    Progress in neurobiology, 2020, Volume: 189

    Topics: Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Down-Regulation; Epigenesis, Genetic; Female; Glutamic Acid; Hyperalgesia; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Somatosensory Cortex; Up-Regulation

2020
Food in Chronic Pain: Friend or Foe?
    Nutrients, 2020, Aug-17, Volume: 12, Issue:8

    Topics: Aspartame; Chronic Pain; Diet; Diet, Gluten-Free; Diet, Ketogenic; Eating; Food; Food Additives; Glutamic Acid; Humans; Micronutrients; Pain Management; Sodium Glutamate

2020
Glutamate, d-(-)-2-Amino-5-Phosphonopentanoic Acid, and
    Molecular pharmacology, 2020, Volume: 98, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Buffers; Cells, Cultured; Chronic Pain; Glutamic Acid; Humans; Mice; N-Methylaspartate; Neurons; Oocytes; Patch-Clamp Techniques; Primary Cell Culture; Rats; Receptors, Glycine; Recombinant Proteins; Reproducibility of Results; Spinal Cord; Synapses; Synaptic Transmission; Xenopus laevis; Zinc

2020
3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia.
    European journal of pain (London, England), 2021, Volume: 25, Issue:9

    Topics: Brain; Chronic Pain; Female; Fibromyalgia; Glutamic Acid; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy

2021
Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain.
    European journal of pain (London, England), 2021, Volume: 25, Issue:10

    Topics: Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Prefrontal Cortex

2021
Salivary glutamate is elevated in individuals with chronic migraine.
    Cephalalgia : an international journal of headache, 2018, Volume: 38, Issue:8

    Topics: Adult; Biomarkers; Blood-Brain Barrier; Chi-Square Distribution; Chronic Pain; Female; Fibromyalgia; Glutamic Acid; Humans; Middle Aged; Migraine Disorders; Outpatients; ROC Curve; Saliva; Sensitivity and Specificity; Statistics, Nonparametric; Trigeminal Nerve

2018
Protective effect and mechanism of injection of glutamate into cerebellum fastigial nucleus on chronic visceral hypersensitivity in rats.
    Life sciences, 2018, Jun-15, Volume: 203

    Topics: Animals; Animals, Newborn; Behavior, Animal; Cerebellum; Chronic Pain; Disease Models, Animal; Female; Glutamic Acid; Injections; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Visceral Pain

2018
Functional and neurochemical disruptions of brain hub topology in chronic pain.
    Pain, 2019, Volume: 160, Issue:4

    Topics: Adult; Brain; Brain Mapping; Case-Control Studies; Chronic Pain; Cohort Studies; Female; Fibromyalgia; Glutamic Acid; Glutamine; Humans; Hyperalgesia; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Agents; Oxygen; Pain Measurement; Proton Magnetic Resonance Spectroscopy; Visual Analog Scale

2019
Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo.
    Biochemical and biophysical research communications, 2019, 04-30, Volume: 512, Issue:2

    Topics: Animals; Chronic Pain; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inflammation; Male; Membrane Potentials; Models, Neurological; Neuralgia; Neuronal Plasticity; Nociception; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn; Substantia Gelatinosa; Synaptic Transmission

2019
Chronic widespread pain: increased glutamate and lactate concentrations in the trapezius muscle and plasma.
    The Clinical journal of pain, 2014, Volume: 30, Issue:5

    Topics: Adult; Carbon Isotopes; Catastrophization; Chronic Pain; Female; Glutamic Acid; Health Status; Humans; Lactic Acid; Male; Middle Aged; Multivariate Analysis; Muscle, Skeletal; Pain Threshold; Quality of Life; Regression Analysis; Surveys and Questionnaires

2014
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

2014
Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain.
    The journal of pain, 2016, Volume: 17, Issue:1

    Topics: Adult; Cerebral Cortex; Chronic Pain; Endometriosis; Female; Glutamic Acid; Glutamine; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Spectroscopy; Middle Aged; Neural Pathways; Pelvic Pain; Young Adult

2016
Chronic pain causes a persistent anxiety state leading to increased ethanol intake in CD1 mice.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:2

    Topics: Alcohol Drinking; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chronic Pain; Depression; Disease Models, Animal; Ethanol; Glutamic Acid; Hyperalgesia; Interleukin-6; Male; Mice; Prefrontal Cortex; Serotonin; Time Factors

2016
Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain.
    Neuropharmacology, 2016, Volume: 105

    Topics: Amygdala; Animals; Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interneurons; Male; MAP Kinase Signaling System; Neuropeptides; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Pyrimidines; Rats; Rats, Sprague-Dawley; Tachykinins

2016
Glutamate-based depression GBD.
    Medical hypotheses, 2012, Volume: 78, Issue:5

    Topics: Affect; Alzheimer Disease; Arthritis, Rheumatoid; Chronic Pain; Cognition; Coronary Artery Disease; Depression; Diabetes Complications; Fibromyalgia; Glutamic Acid; Gyrus Cinguli; Humans; Huntington Disease; Inflammation; Interferons; Models, Neurological; Models, Psychological; Parkinson Disease; Receptors, N-Methyl-D-Aspartate; Risk Factors; Stroke; Synaptic Transmission

2012
Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord.
    Pain, 2012, Volume: 153, Issue:12

    Topics: Animals; Chronic Pain; Glutamic Acid; Male; Neuralgia; Neurotransmitter Agents; Peripheral Nerve Injuries; Posterior Horn Cells; Rats; Rats, Sprague-Dawley

2012
Polysaccharide glucomannan isolated from Heterodermia obscurata attenuates acute and chronic pain in mice.
    Carbohydrate polymers, 2013, Feb-15, Volume: 92, Issue:2

    Topics: Acute Pain; Analgesics; Animals; Ascomycota; Behavior, Animal; Chronic Pain; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Interleukin-1beta; Ligation; Male; Mannans; Mice; Motor Activity; Nociception; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha

2013